[PDF] Top 20 Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site
Has 10000 "Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site" found on our website. Below are the top 20 most common "Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site".
Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site
... progressing HIV-1-infected donor and was shown to neu- tralize diverse HIV-1 strains by binding to the conserved CD4 binding site (CD4bs) of ...characterized ... See full document
13
Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120
... Few broadly neutralizing antibodies targeting determinants of the HIV-1 surface envelope glycoprotein (gp120) involved in se- quential binding to host CD4 and ... See full document
13
Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies
... for HIV-1 (46) and may prove similarly useful for development of HIV-1 vaccines by highlighting common polymorphisms that confer neutralization sensitivity and ...of HIV-1 Env ... See full document
10
Hyperglycosylated Stable Core Immunogens Designed To Present the CD4 Binding Site Are Preferentially Recognized by Broadly Neutralizing Antibodies
... The HIV-1 surface envelope glycoprotein (Env) trimer mediates entry into CD4 ⴙ CCR5 ⴙ host ...possesses conserved antigenic determinants, such as the gp120 primary receptor CD4 ... See full document
16
HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies
... 95% conserved in circulating HIV-1 ...of broadly neutralizing the majority of HIV-1 strains that contain this ...a neutralizing epitope (13) and that other donors ... See full document
13
HIV 1 cell to cell transmission and broadly neutralizing antibodies
... Abstract HIV-1 spreads through contacts between infected and target ...contact site forms the virological ...to HIV-1 spread in vivo. Anti-HIV-1 broadly ... See full document
14
The expanding array of HIV broadly neutralizing antibodies
... of HIV bnAbs since 2009 has generated a huge body of knowlege as to how antibod- ies can overcome the inherent obstacles in targeting a highly variable pathogen with a conformational variable surface protein, such ... See full document
12
New Connections: Cell-to-Cell HIV-1 Transmission, Resistance to Broadly Neutralizing Antibodies, and an Envelope Sorting Motif
... in neutralizing one T/F Env during cell-to-cell ...characterized CD4 binding site bnAb that has been passively administered to chroni- cally HIV-1-infected individuals (43) and ... See full document
7
Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12
... macrophage-tropic HIV strains play a role in the establishing long-lived cellular reservoirs in macro- phage-rich tissues that include brain, lung, gut, and bone marrow ...after CD4+ T cells are depleted ... See full document
7
HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies
... been selection for viral escape through reduced CD4 binding, which can vary greatly between different HIV-1 envelopes ...of broadly neutralizing antibodies (BNAbs) ... See full document
8
Role of Human Immunodeficiency Virus Type 1 Envelope Structure in the Induction of Broadly Neutralizing Antibodies
... isolating broadly reactive CD4bs-directed NAbs from human B cells is probably due to the use of immuno- gens that are reactive with many HIV-1-specific antibodies, in- cluding nonneutralizing ... See full document
12
Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope
... the selection pressure that a given node has experienced using the BASELINe ...of selection pressure by comparing the observed number of re- placement/silent mutations in the CDRs/FWRs of the ... See full document
15
Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01 AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site
... tralizing antibodies, and are therefore candidates for vac- cine ...an HIV vaccine has been under Table 9 The VRC01 susceptibility of AE-Env clones containing D185 and the derived ... See full document
17
Epitope Mapping of Broadly Neutralizing HIV-2 Human Monoclonal Antibodies
... by HIV-2 leads to the elicitation of high titers of broadly neutralizing antibod- ies (NAbs) against primary HIV-2 strains ...the envelope (Env) binding and neutralization prop- ... See full document
14
HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins
... The HIV-1 Env CoRbs is a conserved functional element crit- ical for Env-mediated virus entry, and the accessibility to this re- gion is limited on the HIV-1 primary virus Env ... See full document
11
Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
... of HIV-1 acquisition within mucosal tissue may prove critical to effective vaccine de- velopment and the prophylactic use of monoclonal ...virus, antibodies targeting different sites of ... See full document
16
CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies
... between CD4-Ig and VRC01-class bNAbs. As mentioned, CD4-Ig more efficiently promotes CD4i antibody binding to monomeric gp120 and trim- eric ...CD4bs antibodies for two possible ...cellular ... See full document
11
Neutralization Synergy between HIV-1 Attachment Inhibitor Fostemsavir and Anti-CD4 Binding Site Broadly Neutralizing Antibodies against HIV
... DISCUSSION Given that new drug development is an extremely time-consuming and expensive process, study of the interaction between small molecules and biologics already known to be efficacious may be a more time- and ... See full document
17
The Development of CD4 Binding Site Antibodies during HIV-1 Infection
... CD4bs neutralizing antibodies with heavy- chain nucleotide substitution rates of 24% to 31% compared to germ line antibody gene sequence (29, ...BNCD4-like antibodies is due in part to the level of ... See full document
8
Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.
... When the gpl20 binding assay was performed in the presence of the neutralizing monoclonal antibodies 0.5,B and 9284, there was no inhibition of binding to the CD4+ cells (Fig. 2), even a[r] ... See full document
6
Related subjects