[PDF] Top 20 Selective spread of herpes simplex virus in the central nervous system after ocular inoculation.
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Selective spread of herpes simplex virus in the central nervous system after ocular inoculation.
... In a similar fashion, axonal transport was probably responsible for the spread of the virus to the neurons of the midline raphe nuclei, nucleus locus coeruleus, and VII nerve nuclei by 5[r] ... See full document
6
Tracking the Spread of a lacZ-Tagged Herpes Simplex Virus Type 1 between the Eye and the Nervous System of the Mouse: Comparison of Primary and Recurrent Infection
... This spread of infection within the TG, perhaps involving the “back- door route”, has been described and discussed previously (36, 42, ...of virus out along axons, and then the emergence of such ... See full document
11
Role of Interleukin-2 and Herpes Simplex Virus 1 in Central Nervous System Demyelination in Mice
... Injection of mice with IL-2 DNA induces CNS demyelination following ocular HSV-1 infection. It has been shown previously that DNA vaccine-encoded immunogens can elicit an immune response (26, 27). To test our ... See full document
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Role of Specific Innate Immune Responses in Herpes Simplex Virus Infection of the Central Nervous System
... oculation with HSV-1 but that in the context of TLR2 or TLR9 deficiency alone, intracorneal inoculation with HSV-1 does not lead to encephalitis and results in a localized corneal infection (24). Others reported ... See full document
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The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.
... of virus was the highest at this site, and hence it is conceivable that some of the effects observed at this site represent the results of a high multiplicity of ...(ii) Virus spread from the site of ... See full document
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Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System
... Effect of overexpression of cellular endogenous dUTPase on replication and virulence of HSV-1 with the vdUTPase S187A mutation. To investigate a direct linkage between low cellular dUTPase activity and HSV-1 replication ... See full document
8
Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System
... the nervous system. Although the CNS is infected by viral spread through the nerves, the main pathway of HSV-1 to the organs in neonates (1) and in immunosuppressed humans (23) is the ... See full document
5
The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice Is a Major Cause of Central Nervous System Pathology Resulting in Fatal Encephalitis
... clearing virus late in infection, they do not play a role in limiting spread of virus from peripheral sites of infection to sensory ganglia and the CNS (16, ... See full document
11
Herpes Simplex Virus Type 1 Glycoprotein E Domains Involved in Virus Spread and Disease
... of virus to spread from inoculation site to ganglia and likely from ganglia back to skin, based on a number of reports (2, 10, 11, 27, ...in spread from neuron to epithelial cells ... See full document
8
Quantitative Analysis of Herpes Simplex Virus Reactivation In Vivo Demonstrates that Reactivation in the Nervous System Is Not Inhibited at Early Times Postinoculation
... the virus strain (RE versus 17syn⫹) ...acute ocular infection and in vivo reactivation are very similar in these two strains of mice with strain 17syn⫹ (unpublished ...The central feature of the ... See full document
12
Role of Microvesicles in the Spread of Herpes Simplex Virus 1 in Oligodendrocytic Cells
... ABSTRACT Herpes simplex virus 1 (HSV-1) is a neurotropic pathogen that can in- fect many types of cells and establishes latent infections in the neurons of sensory ...the virus spreads into ... See full document
19
Phosphorylation of a Herpes Simplex Virus 1 dUTPase by a Viral Protein Kinase, Us3, Dictates Viral Pathogenicity in the Central Nervous System but Not at the Periphery
... intracranial inoculation and that the phosphomimetic substitution at vdUTPase Ser-187 in part restored the wild-type mortality and viral ...following ocular and vaginal inoculation, re- ... See full document
11
Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors
... the virus from the substantia nigra was examined by determining whether specific staining was present in the striatum after virus ...the virus injection ...the virus by the ... See full document
12
Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
... Viruses. Wild-type HSV type 1 (HSV-1) RE and HSV-1 KOS1.1 were prop- agated and assayed on Vero cells by measurement of PFU or 50% tissue culture infective doses by standard protocols. The mutant viruses (d301 and n504) ... See full document
7
Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus.
... 8. Spread of HSV-1 gE 2 gI 2 , and gD 2 mutant viruses in cultures of dissociated rat sensory ...infected. After 2 h, the cultures were washed with PBS and overlaid with MEMN–10% FBS supplemented with ... See full document
12
Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome.
... 749 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Herpes simplex virus type 1 HSV-1 DNA and RNA have been detected in peripheral nervous system PNS and central nervou[r] ... See full document
8
Mode of spread to and within the central nervous system after oral infection of neonatal mice with the DA strain of Theiler's murine encephalomyelitis virus.
... FIG. 5. Three-dimensional distribution of virus lesions in the brain of a mouse at 8 days p.i. Adobe Photoshop software was used to trace the anatomical boundaries on representative digitalized images from a ... See full document
8
Development and Optimization of Herpes Simplex Virus Vectors for Multiple Long-Term Gene Delivery to the Peripheral Nervous System
... pinna inoculation route has been used, which requires transport from the inoculation site to the cell body in the ...following inoculation of mice by the footpad or ear pinna ...A virus with ... See full document
15
Varicella-Zoster Virus (VZV) Glycoprotein E Is a Serological Antigen for Detection of Intrathecal Antibodies to VZV in Central Nervous System Infections, without Cross-Reaction to Herpes Simplex Virus 1
... To investigate the eventual cross-reactivity of IgG to the VZV gE antigen in patients with HSE, ELISAs were per- formed on the CSF and serum samples from such patients and compared to corresponding results with the ... See full document
7
Alpha and Gamma Interferons Inhibit Herpes Simplex Virus Type 1 Infection and Spread in Epidermal Cells after Axonal Transmission
... of herpes simplex virus type 1 (HSV-1) from neuronal axon to epidermal cells (ECs), and subsequent spread in these cells was investigated in an in vitro dual-chamber model consisting of human ... See full document
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