[PDF] Top 20 Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral Envelope Glycoprotein B and Regulates Its Expression on the Cell Surface
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Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral Envelope Glycoprotein B and Regulates Its Expression on the Cell Surface
... the cell surface is a potent inducer of the immune response in vivo (4, 5, 49, 50), and it has been speculated that the downregulation of the cell surface expression of gB by ... See full document
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Herpes Simplex Virus 1 US3 Phosphorylates Cellular KIF3A To Downregulate CD1d Expression
... the expression of repre- sentative cell surface proteins by using different recycling routes upon viral ...increased expression of these two proteins is important for the viral ... See full document
10
Role of the Herpes Simplex Virus 1 Us3 Kinase Phosphorylation Site and Endocytosis Motifs in the Intracellular Transport and Neurovirulence of Envelope Glycoprotein B
... the cell surface, like the gBs of other members of the Herpesviridae family, including pseu- dorabies virus (PRV), human cytomegalovirus (HCMV), and varicella-zoster virus (VZV) (4, 13, 18, ... See full document
13
Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene
... Us3 protein kinases encoded by herpes simplex virus 1 (HSV-1) and 2 (HSV-2) play important roles in viral replication and ...HSV-1 Us3 and HSV-2 ... See full document
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Herpes Simplex Virus 1 Protein Kinase US3 Hyperphosphorylates p65/RelA and Dampens NF-κB Activation
... and viral transcrip- tion factors, modulate their activities, and regulate downstream ...BGLF4 phosphorylates UXT at the Thr3 ... B-mediated repression of the EBV lytic infection ... B ... See full document
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Myosin Va Enhances Secretion of Herpes Simplex Virus 1 Virions and Cell Surface Expression of Viral Glycoproteins
... of herpes simplex virus (HSV) virions requires virion-laden vesicles to bypass cortical actin and fuse with the plasma membrane, releasing virions into the extracellular ...or viral proteins ... See full document
8
Herpes Simplex Virus 1 Protein Kinase Us3 and Major Tegument Protein UL47 Reciprocally Regulate Their Subcellular Localization in Infected Cells
... a protein kinase is tightly regu- lated; ...other protein kinases, or interaction with other proteins ...activated protein kinase phosphorylates a substrate(s), and as a result, ... See full document
15
Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
... and its phosphorylation sites must be ...mutant virus lacking the protein kinase activity is also detected in cells infected with a mutant virus in which the substrate’s phosphorylation ... See full document
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Phosphorylation of the UL31 Protein of Herpes Simplex Virus 1 by the US3-Encoded Kinase Regulates Localization of the Nuclear Envelopment Complex and Egress of Nucleocapsids
... One-step viral growth ...per cell of the viruses shown in ...for 1 h at 37°C, residual surface infectivity was inactivated with a low-pH wash (40 mM citric acid [pH ...infectious virus ... See full document
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Herpes Simplex Virus 1 Glycoprotein B and US3 Collaborate To Inhibit CD1d Antigen Presentation and NKT Cell Function
... Herpes simplex viruses (HSVs) are prevalent human pathogens that establish latency in human neuronal cells and efficiently evade the immune ...type 1 (HSV-1) rapidly and efficiently ... See full document
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Phosphorylation of a Herpes Simplex Virus 1 dUTPase by a Viral Protein Kinase, Us3, Dictates Viral Pathogenicity in the Central Nervous System but Not at the Periphery
... reduced viral replication and pathogenicity in mice, both in the CNS following intracranial inoculation and in peripheral sites following inocula- tion at these ...reduced viral replication and pathogenesis ... See full document
11
Regulation of the Catalytic Activity of Herpes Simplex Virus 1 Protein Kinase Us3 by Autophosphorylation and Its Role in Pathogenesis
... HSV-1-encoded protein kinase, phosphorylates Us3 in infected cells ...of Us3 for the regulatory activity of Us3 has not been ...at Us3 residue 147 (Us3 ... See full document
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Effects of Phosphorylation of Herpes Simplex Virus 1 Envelope Glycoprotein B by Us3 Kinase In Vivo and In Vitro
... a Us3 kinase- inactive mutant ...of Us3 phosphorylation of gB Thr-887, includ- ing regulation of proper cell surface expression of gB and promotion of nuclear egress of ... See full document
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Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral dUTPase and Regulates Its Catalytic Activity in Infected Cells
... Herpes simplex virus 1 (HSV-1) is one of the best-character- ized members in the subfamily Alphaherpesvirinae of the family Herpesviridae and is the etiologic agent of a variety of ... See full document
12
Herpes Simplex Virus 1-Encoded Protein Kinase UL13 Phosphorylates Viral Us3 Protein Kinase and Regulates Nuclear Localization of Viral Envelopment Factors UL34 and UL31
... of Us3 is due to phosphorylation, the infected-cell lysates were phosphatase treated with CIP, solubilized, and analyzed by immunoblotting with polyclonal antibody to ...both Us3 isoforms from Vero ... See full document
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Insertion Mutations in Herpes Simplex Virus 1 Glycoprotein H Reduce Cell Surface Expression, Slow the Rate of Cell Fusion, or Abrogate Functions in Cell Fusion and Viral Entry
... FIG. 1. (A) Effects of insertional mutations of HSV-1 gH on cell surface ...The cell surface expression of gH or gH mutants was quantified by CELISA using anti-gH (52S) ... See full document
9
Influence of asparagine-linked oligosaccharides on antigenicity, processing, and cell surface expression of herpes simplex virus type 1 glycoprotein D.
... The mutant protein lacking N-CHO at site 1 Asn-94 had a reduced affinity for monoclonal antibodies MAbs to discontinuous epitopes, suggesting that the conformation of the protein had bee[r] ... See full document
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Identification of a Physiological Phosphorylation Site of the Herpes Simplex Virus 1-Encoded Protein Kinase Us3 Which Regulates Its Optimal Catalytic Activity In Vitro and Influences Its Function in Infected Cells
... recombinant virus expressing VenusA206K- Us3S147A and the repaired ...of Us3 is phosphorylated in HSV-1-infected ...of Us3 immunoprecipitated by specific antibody from wild-type ... See full document
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Isolation of a protein kinase induced by herpes simplex virus type 1.
... The pooled individual peaks were 383 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have isolated a new cyclic AMP-independent protein kinase activity induced in He[r] ... See full document
6
Expression of the Viral Thymidine Kinase Gene in Herpes Simplex Virus-Transformed L Cells
... treatment, as shown by the nearly two-fold Experiments with both synchronized and asynincrease in cell number at the end of metaphase chronous cultures strongly suggest that the viral an[r] ... See full document
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