[PDF] Top 20 Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer
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Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer
... in cancer genomics enables the identification of potential therapeutic targets from genomic alterations that have been long ignored due to their classification as nondriver muta- tions (20, ...the ... See full document
16
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
... Somatic mutation underpins the development of cancer, and most solid tumors have thousands to tens of thousands of point mutations, coupled with tens to hundreds of genomic rearrange- ments and ... See full document
16
Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation
... by cancer susceptibility regions might affect other host factors — for example, the cells responsible for the im- mune response to tumors — and we may, therefore, be looking at mutation frequencies in the ... See full document
11
Likelihood Models of Somatic Mutation and Codon Substitution in Cancer Genes
... of somatic mutation in cancer is well established and several genes have been identified that are frequent ...of somatic mutations in cancers of particular organs. Cancer gene ... See full document
12
Somatic mutation and gain of copy number of PIK3CA in human breast cancer
... gene mutation and 4 cases did not harbor a mutation but showed a gain of gene copy ...a mutation or gain of copy number of the ...that somatic mutations are a major contributory factor in the ... See full document
8
Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway
... of somatic mutation in the EGFR pathway for different solid tumour ...by mutation status for commonly mutated components of the EGFR pathway, including EGFR, KRAS, BRAF, PIK3CA and ...non-synonymous ... See full document
8
Nitrite in Public Water-Supply Is a Health Hazard
... The cancer cells are different from normal human body ...the Somatic Mutation Theory guessed that cancer is caused when mutations have caused the Human Genome of the human body-cells to change ... See full document
6
PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data
... terious somatic mutations in HRAS (G13 V), NF1 (K297*), and RAF1 (M562I) ...of cancer types including melanoma, prostate, and colorectal cancer, and provides the rationale for combin- ing ... See full document
11
Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non small cell lung cancer
... in cancer remains unknown. Additional evidence showed that somatic mutations in the NIPBL gene were found in gastric and colorectal cancers with high microsatellite instability ...the cohesin ... See full document
12
CRlncRC: a machine learning-based method for cancer-related long noncoding RNA identification using integrated features
... predict cancer-related ...of cancer-related lncRNAs, as compared with some previous ...the cancer-related lncRNA prediction, wherein epigenetic and genomic features play key roles in the ...of ... See full document
14
Recurrent KRAS Codon 146 mutations in human colorectal cancer
... point mutation in codon 12 of the HRAS gene was the first somatic point mutation identified in a human cancer and established the role of somatic mutations as the common driver of ... See full document
12
MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis
... a mutation set enrichment analysis (MSEA) to study mutation hotspots in genes and hypothesized that genes with mutation hotspots may serve as candidate cancer ...higher mutation rate ... See full document
16
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment
... on cancer,” cancer remains one of the major causes of human morbidity and ...tumor-specific therapeutic targets of prime ...breast cancer tumorigenesis, can be targeted by two types of ... See full document
11
Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development
... in cohesin and its regulators are responsible for Cornelia de Lange syndrome (CdLS) [18–23], a rare developmental disease characterized by both chromosome aneuploidies and aberrations, preco- cious sister ... See full document
16
<p>Poor Prognosis With Coexistence Of <em>EGFR</em> T790M Mutation And Common <em>EGFR</em>-Activating Mutation In Non- Small Cell Lung Cancer</p>
... T790M mutation varied with analyses using different detection meth- ods and ranged from ...T790M mutation was ...EGFR mutation status by ...T790M mutation is a somatic muta- tion, ... See full document
10
Cell Cycle Control of Kaposi's Sarcoma-Associated Herpesvirus Latency Transcription by CTCF-Cohesin Interactions
... RNA splicing of latency-associated transcripts is not altered by the cell cycle. Since KSHV gene transcripts located in a latency transcriptional unit are produced by complex splicing, it was reasonable to test if ... See full document
12
Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer
... oesophagogastric cancer harbouring MYC and/or ERBB2 amplifications (ibrutinib in MYC amplified oesophageal cancer (iMYC)trial — NCT NCT02884453) who have progressed after first-line ... See full document
14
Genetic basis of cohesinopathies
... of cohesin being currently partial and incomplete, and perhaps the term “chromosome structure architects” or “architectins” would be more ...the cohesin complex and specific regulator proteins model ... See full document
9
Mutations on the N-Terminal Edge of the DELSEED Loop in either the α or β Subunit of the Mitochondrial F1-ATPase Enhance ATP Hydrolysis in the Absence of the Central γ Rotor
... (Fig. 5B). This suggests that the ␣ subunit is associated with  and likely to form a subcomplex in vivo to hydrolyze ATP in the ab- sence of ␥ . We found that in the pull-down products, the stoichi- ometry ... See full document
11
Meier-Gorlin syndrome
... In this review, we outline the clinical symptoms of MGS and propose experience-based guidelines for care and treatment of MGS patients. The reported percentages of clinical symptoms are calculated from the frequency of ... See full document
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