[PDF] Top 20 Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT AKI): study protocol for a randomized controlled trial

... Background: Acute kidney injury is a common and devastating complication of critical illness, for which renal replacement therapy is frequently needed to manage severe ...” ... See full document

... Simplified Acute Physiology Score (SAPS) III severity score [18] and Sequential Organ Failure Assess- ment score (SOFA) score [19] are ...fluid therapy, catecholamine and anticoagulant administration are ... See full document

... Although renal replacement therapy (RRT) remains the primary supportive management strategy for patients with severe AKI, it could also be associated with com- plications and adverse events ... See full document

... al. study [14], where 14-day mortality within the “early” group was 14 % (2 of 14), compared with 86 % (12 of 14) in the “late” group (p < ...this study was included in our quantitative analysis, the ... See full document

... Detailed clinical procedure-related RRT parameters, and physiologic and laboratory data will be collected. Blood and urine will be collected at baseline, 12, 24, 36 and 48 hr and once daily thereafter until the ... See full document

... of renal replacement therapy (RRT) for acute kidney injury (AKI) in the intensive care unit (ICU) when short-term life-threatening metabolic abnormalities are ... See full document

... and acute illness ...Our study included assessment of early clinical deterioration (within the first 48 h after RRT initiation), which, to date has not been examined in the literature and showed that ... See full document

... in AKI patients with traditional indications, the advantages of commencing RRT in the absence of life-threatening complications are still under controversial ...early initiation of RRT is related to reduced ... See full document

... five randomized controlled trials (RCTs) and reported a significant survival benefit when RRT was started ...in study quality, pub- lication bias, heterogeneous patient populations ...various ... See full document

... early versus late initiation of ...early initiation of RRT using serum urea as surrogate marker ...tional study analyzed data on timing of initiation of RRT based on the median BUN at ... See full document

... be randomized in a 1:1 fashion using closed ...be randomized to the active use of RenalGuard system versus using passive use of the Renal- Guard system using normal saline ...(sham- ... See full document

... of AKI patients with increase in AKI staging had been observed in other studies by Bhandary ...of AKI stage 1 patients may represent the usually asymptomatic and undiagnosed cases of AKI who ... See full document

... during renal replacement therapy (HIRRT) in the form of intradia- lytic hypotension (IDH) frequently complicates main- tenance hemodialysis treatments in end-stage kidney disease (ESKD) ... See full document

... normal kidney, a small amount of serum albu- min goes through the glomerular filter, and almost all of the albumin in the tubule is ...the renal cortex [27]. AKI can be detected earlier by urinary ... See full document

... primary renal failure, secondary to a variety of pathologic conditions affecting the kidney, is usually treated in non-intensive care units and has rela- tively good prognosis and low mortality (5-10%) ... See full document

... INTRODUCTION: Acute kidney injury (1) depicts the abrupt decline in renal function mostly occurs over the course (hours to days) and ends in retention of metabolic waste products and ... See full document

... The old “credo” stating that fluid harms the lung but benefits the kidney should be revised [10]. Liberal fluid administration is of key importance to optimize systemic hemodynamics in patients with SAKI. Yet, ... See full document

... We used an arbitrary cutoff of an intra-treatment MAP decline of 20% as part of the composite outcome for hemodynamic instability. Nonetheless, our results remained robust in sensitivity analyses that used differ- ent ... See full document

... Severe acute kidney injury (AKI) can be treated with either continuous renal replacement therapy (CRRT) or intermittent renal replacement therapy ... See full document

... particularly analyzing a cohort of patients who simultaneously received renal replacement and drotrecogin A activated (DrotAA). A single-center, retrospective observational study was conducted in an ... See full document