[PDF] Top 20 Stoichiometry of Monoclonal Antibody Neutralization of T-Cell Line-Adapted Human Immunodeficiency Virus Type 1
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Stoichiometry of Monoclonal Antibody Neutralization of T-Cell Line-Adapted Human Immunodeficiency Virus Type 1
... (19). Virus was generated by env transcomplementation by cotransfection of equal amounts of pSV-A308 and pSV-A308T321, pSV-A308T321, and pSV- A308K373 and by transfection of pSV-A308K373 ...lope-complemented ... See full document
7
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.
... primary virus envelope glycoproteins demonstrated less sensitivity to neutralizing antibodies directed against the CD4-binding site or the V3 loop, relative to that seen for the HXBc2 envelope ...of ... See full document
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Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1.
... activated T cells generally express much higher levels of adhesion ...the type of cell from which the virus buds ...different cell types alters sensitivity to neutralization ... See full document
5
In Vivo gp41 Antibodies Targeting the 2F5 Monoclonal Antibody Epitope Mediate Human Immunodeficiency Virus Type 1 Neutralization Breadth
... (A) Neutralization titers for 2F5-sensitive virus TND_669S (dark blue) and 2F5-resistent virus TND_669S/K665N (light blue) are shown with the bars and plotted on the primary y ...gray line and ... See full document
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Effect of Epitope Position on Neutralization by Anti-Human Immunodeficiency Virus Monoclonal Antibody 2F5
... 2F5 antibody specifically neutralizes MLV with 2F5 ⴖ in SU. Cell fusion and virus infection do not always correlate (13, 14, 51, 54, ...2F5 antibody also neutralized MLV with 2F5 ⬙ in Env, we ... See full document
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Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization
... Human immunodeficiency virus type 1 (HIV-1) is the etio- logical agent of ...to antibody-mediated neutralization, but they are generally more resistant than the ... See full document
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Distinction of human immunodeficiency virus type 1 neutralization and infection enhancement by human monoclonal antibodies to glycoprotein 120
... on T lymphoid cells and Fc receptors for IgG (Fc gamma R) on monocytic cells are required for enhanced infection by antibody-complexed ...IgG human monoclonal antibodies (HMAbs) reactive ... See full document
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Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1
... Kingdom). Virus (320SI) was regenerated by electro- poration and expansion in phytohemagglutinin-activated pe- ripheral blood lymphocytes ...PI virus to growth in an established T-cell ...H9 ... See full document
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Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization
... a human cell line lacking N- acetylglucosamine transferase I (GnTI), the enzyme that initiates the conversion of oligomannose N-glycans into complex ...mutant virus lacking a complex N-glycan ... See full document
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Induction of Neutralizing Antibodies to T-Cell Line-Adapted and Primary Human Immunodeficiency Virus Type 1 Isolates with a Prime-Boost Vaccine Regimen in Chimpanzees
... contain human immunodeficiency virus type 1 (HIV-1) infection, stimulation of cellular immunity is more critical than induction of antibod- ies (Abs) because infection is thought ... See full document
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Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
... of cell surface CXCR4 expression deter- mined by flow cytometry after 12G5 staining of the CD4 1 T-cell lines MOLT-4 and C8166, the CD4-transfected human rhabdomyosarcoma cell ... See full document
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Mechanisms of human immunodeficiency virus Type 1 (HIV-1) neutralization: irreversible inactivation of infectivity by anti-HIV-1 antibody.
... and virus isolate from dif- ferent sources) was generally better against laboratory-adapted isolates than against primary patient isolates (Table ...conventional neutralization assays (12, 29, 37, ... See full document
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Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.
... by virus or cell culture conditions, which have been suggested to influence HIV-1 neutralization (56, ...[Table 1]) can be detected by this ...the cell surface, the quantity of ... See full document
7
Interactions between Natural Killer Cells and Antibody Fc Result in Enhanced Antibody Neutralization of Human Immunodeficiency Virus Type 1
... sorbing antibody-coated virus to CD4 ⫹ lymphocytes at 4°C, thereby blocking fusion and ...cells. Antibody bound to ad- sorbed virus by its Fab could interact through its Fc segment with NK ... See full document
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Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1
... stomatitis virus G glycoprotein, indicates that at least 2 logs of this defectiveness can be attributed to the HIV-1 Env glycoproteins ...actual T value, in both this study and in the analysis of ... See full document
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Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies
... C virus neutralization in our panel does not rule out the possibility that 2F5 may occasionally neutralize viruses from this ...only 1 of 71 [1%] clade C sequences from ...from ... See full document
21
Antibody-Mediated Neutralization of Primary Human Immunodeficiency Virus Type 1 Isolates: Investigation of the Mechanism of Inhibition
... the neutralization of PI may be largely ...by antibody mapping (7, 32, 34) have been found to be exposed on several TCLA strains but occluded or masked on PI (5, ...neutralizing monoclonal antibodies ... See full document
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Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.
... The basic quantities and their relationships. We let the number of CD4- binding sites, SU monomers, on a virion 5 N. This number may vary from 0 to a maximal value, a multiple (depending on the oligomeric state of Env ... See full document
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Study of the V3 Loop as a Target Epitope for Antibodies Involved in the Neutralization of Primary Isolates versus T-Cell-Line-Adapted Strains of Human Immunodeficiency Virus Type 1
... gous virus, was related to a lower risk of mother-to-child trans- mission (56, 57), and it was postulated that a broad cross- reactive NAb response may reduce the risk of transmission of HIV-1 by ... See full document
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Stoichiometry of Antibody Neutralization of Human Immunodeficiency Virus Type 1
... ⫽ 1/T ⫽ 1 neutralization stoichiometry means that although each envelope trimer needs to bind only one neutral- izing antibody to be inactivated, essentially every functional ... See full document
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