[PDF] Top 20 Structural Basis for the Receptor Binding Specificity of Norwalk Virus
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Structural Basis for the Receptor Binding Specificity of Norwalk Virus
... the structural basis for differences in ligand recognition of noroviruses from different genogroups, the prototypic Norwalk virus (NV; GI-1) and VA387 (GII-4), which recognize the same A ... See full document
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Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
... our structural analysis is that the substrate-in- duced changes in the S4 pocket are correlated with alterations in the S2 ...A structural basis for such coordinated changes is evident by considering ... See full document
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Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution
... the structural basis of the preferential binding of 09H1 to ␣2,6-linked receptors using an engineered HA in which a disulfide was introduced to stabilize the protein ...09H1-human receptor ... See full document
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Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6
... H5N1 virus, and less attention is paid to other avian HA subtypes ...the receptor binding properties of these avian subtypes could contribute to the understanding of host range switching during ... See full document
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Structural Determinants of Chemokine Binding by an Ectromelia Virus-Encoded Decoy Receptor
... The identification of a binding surface on EVM1 has impli- cations for this entire family of chemokine binding proteins. We envision that the initial interaction of chemokines with EVM1 involves a rapid ... See full document
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Structural Characterization of the Hemagglutinin Receptor Specificity from the 2009 H1N1 Influenza Pandemic
... a binding preference for human-like ␣ 2-6 sialylated glycans ...glycan receptor analogs (43) and neoglycolipid-based carbohydrate microarray analysis of whole viruses (11) suggested the dual ... See full document
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Effects of Receptor Binding Specificity of Avian Influenza Virus on the Human Innate Immune Response
... the receptor specificity of the influenza viruses in human primary ...the virus with ␣ 2,3-linked SA receptor specificity induced a higher expression of proinflammatory genes by DCs and ... See full document
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Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses
... A virus is of avian origin and is spread by migrating ...pandemic virus (1, ...the receptor speci- ficity of the hemagglutinin (HA) ...A virus serotypes that have circulated in hu- mans to ... See full document
6
Interactions between the two surface proteins of rotavirus may alter the receptor-binding specificity of the virus.
... VP4 interacts closely with VP7 on the surface of the mature rotavirus particles, and it has been shown that this interaction may affect the antigenic properties of VP4. Analysis of reas- sortant viruses having the ... See full document
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Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes
... Although largely mediated by their sugar moiety, the bind- ing of various ligands to ASGP-R occurs within a broad range of affinity and with a certain degree of specificity (62). Thus, asialo-orosomucoid and ... See full document
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Quantifying the effects of mutations on receptor binding specificity of influenza viruses
... the binding of HA to sialylated glycan receptors on the host ...H1N1 virus. The adaptation of the virus to a new host entails the compatibility between host and virus genetic requirements to ... See full document
14
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
... MHC binding, we focused on assessing the solvent exposed positions P3, P4, P5, P6 and ...TCR binding (,5-fold reduction) (Figure ...TCR binding by more than 60-fold to ...TCR binding to ... See full document
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Properties of the Naturally Occurring Soluble Surface Glycoprotein of Ecotropic Murine Leukemia Virus: Binding Specificity and Possible Conformational Change after Binding to Receptor
... the receptor mCAT-1, which was originally described as ...immunodeficiency virus-1 (HIV-1) and simian immu- nodeficiency virus ...The binding of soluble receptor CD4 to HIV-1 and SIV ... See full document
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Interaction of Recombinant Norwalk Virus Particles with the 105-Kilodalton Cellular Binding Protein, a Candidate Receptor Molecule for Virus Attachment
... a specificity similar to picornavirus 3C proteases and that the nonstructural precursor polyprotein of SAV is cleaved into at least six smaller products (44, 45, ...into virus-like particles ...of ... See full document
9
RNA Bind-n-Seq: Quantitative Assessment of the Sequence and Structural Binding Specificity of RNA Binding Proteins
... and structural specificity of RNA binding proteins (RBPs), and its application to the developmental alternative splicing factors RBFOX2, CELF1/CUGBP1 and ...near-optimal binding motifs. RNA ... See full document
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Diagnosis of Norwalk Virus Infection by Indirect Enzyme Immunoassay Detection of Salivary Antibodies to Recombinant Norwalk Virus Antigen
... to collect stool specimens and paired acute- and convalescent- phase saliva samples from nine infected subjects, one exposed control subject, and four unexposed control subjects (Table 4). The infected subjects were ... See full document
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Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India
... With different types of RBCs, variation in HA and HI titers was observed among isolates of the same subtype. Therefore to conclude overall performance or reactivity of RBCs, calculation of GMT among the same subtype was ... See full document
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Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor
... by binding at the enzyme’s active site ...the virus (7) and the possible infidelity of HIV-1 reverse transcriptase, mutations are generated frequently, thus allow- ing drug-resistant variants to emerge ... See full document
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Development of Norwalk Virus-Specific Monoclonal Antibodies with Therapeutic Potential for the Treatment of Norwalk Virus Gastroenteritis
... strain Norwalk virus (NV) (genogroup ...with Norwalk recombinant virus-like particles (rVLPs) were recovered, with estimated binding affinities in the subnanomolar ...for Norwalk ... See full document
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Substitutions in the Receptor-Binding Domain of the Avian Sarcoma and Leukosis Virus Envelope Uncouple Receptor-Triggered Structural Rearrangements in the Surface and Transmembrane Subunits
... the receptor-binding domain (RBD) within EnvA. Receptor spec- ificity maps to two small, highly variable domains, hr1 and hr2, within the SU subunit (4, 5, 14, ...bind receptor, exemplified by ... See full document
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