[PDF] Top 20 The Structural Interface between HIV-1 Vif and Human APOBEC3H
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The Structural Interface between HIV-1 Vif and Human APOBEC3H
... the Vif-binding site on A3H and the A3H-binding site on HIV-1 ...specific Vif-A3H amino acid pairs allowed us to generate a detailed Vif-A3H structure model, which we subsequently ... See full document
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A Single Amino Acid Difference in Human APOBEC3H Variants Determines HIV-1 Vif Sensitivity
... that HIV-1 Vif does indeed interact with A3H_HapII and induces proteasome-me- diated degradation through a mechanism similar to that re- sponsible for A3G ...interaction between A3H_HapII and ... See full document
10
The Range of Human APOBEC3H Sensitivity to Lentiviral Vif Proteins
... The APOBEC3H gene is polymorphic in humans, with four major population-dependent haplotypes that encode proteins with different levels of antiviral ...against human immunodeficiency virus type 1 ... See full document
8
Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 Activity
... binds HIV-1 nucleocapsid in an RNA-dependent manner, and a single Y112A mutation completely disrupts A3H virion ...to Vif. Although the previously identified APOBEC3G Vif-responsive motif 128 ... See full document
11
Genetic And Biochemical Studies Of Human Apobec3h Enzyme
... of human APOBEC3H are currently ...with HIV-1 vif in different variants can also be determined by suitable crystal structures with ...of human APOBEC3H protein variants ... See full document
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The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches
... of Vif and A3 biology, it is still not clear how Vif actually binds to an A3 ...refined Vif-A3F interaction model that predicted a durable anchoring electrostatic ...or Vif (R15E) abrogated ... See full document
9
Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1
... to HIV restriction should all share at least five, and possibly six, char- ...into Vif-deficient HIV virions when stably expressed in T ...restrict Vif-deficient HIV when pack- aged ... See full document
15
Structural Insights into HIV-1 Vif-APOBEC3F Interaction
... on Vif revealed that three discontinuous F-box mo- tifs are assembled at one region of the molecule with hydrophobic and positively charged surface ...charged Vif stretch contributes to formation of an ... See full document
14
Interactions between HIV 1 Vif and human ElonginB ElonginC are important for CBF β binding to Vif
... stabilize Vif, especially if there is no consequence on its ...stabilized Vif was not clear, we supposed that, as a molecular chaperone, free EloB might help to stabilize an intermediate folding state of ... See full document
16
Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G
... inhibit Vif-deficient human immunodeficiency virus type 1 (HIV-1) by cata- lyzing cytosine deamination in viral cDNA and impeding reverse ...transcription. HIV-1 counteracts ... See full document
13
Identification of a tripartite interaction between the N terminus of HIV 1 Vif and CBFβ that is critical for Vif function
... the Vif interactome is expand- ing and among these are EloB/C, CUL5, and CBFβ, which are essential for counteracting the antiviral activities of A3 proteins by targeting them for proteasomal degrada- tion [4, 5, ... See full document
13
Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.
... that vif mutant SIV and HIV-2 were unable to establish infection in macaque monkeys and with the renewed concept that vif is an essential gene for in vivo infec- ...and vif mutant viruses, ... See full document
5
HIV-1 and HIV-2 Vif Interact with Human APOBEC3 Proteins Using Completely Different Determinants
... interactions between HIV-2 Vif (Vif2) and the APOBEC3 proteins (11, ...identity between Vif1 from NL4-3 and Vif2 from HIV-2 ROD12 ...to HIV-1 and HIV-2 pos- sessed ... See full document
16
Human immunodeficiency virus type 1 (HIV-1) protein Vif inhibits the activity of HIV-1 protease in bacteria and in vitro.
... of Vif on Gag-PR autoproteolysis of different constructs in the studies reported above indicates that Vif can inhibit processing at many sites on ...of Vif with PR ...of Vif and PR as purified ... See full document
8
APOBEC3G activity of HIV-1 Vif protein in elite HIV controllers.
... variants between high HIV prevalence populations such as Africans and low-HIV populations such as Caucasians suggest the antiviral role of APOBEC3G enzyme may have been involved in shaping the ... See full document
5
MDM2 is a novel E3 ligase for HIV 1 Vif
... The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G ...(A3G). Vif interacts with ... See full document
12
Dissection of the HIV Vif Interaction with Human E3 Ubiquitin Ligase
... of Vif interact with the E3 ...of Vif and investigated their thermodynamic contributions to the ligase assembly in vitro using isothermal titration calorimetry and fluorescence ...interactions ... See full document
5
Polyubiquitination of APOBEC3G Is Essential for Its Degradation by HIV-1 Vif
... SIV Vif shares some critical domains with HIV-1 Vif, such as the BC-box motif and the HCCH motif, which are essential for functional Cullin5 ubiquitin complex formation, there is only around ... See full document
5
Molecular mechanisms of human innate immune restriction factors APOBEC3G and APOBEC3H for inhibiting the retrovirus HIV-1 and retrotransposon LINE1
... the HIV proviral genome is mediated by the level of encapsidation into the viral capsid and the biochemical properties of the A3 [21, ...the HIV viral infectivity factor (Vif) protein [25]. ... See full document
223
Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Two-Amino-Acid Insertion in HIV-1 Vif from a Nonprogressing Mother and Child
... the Vif sequences from the strain from patient X was the primary determinant of poor XV ...of HIV-1 Vif sequences from strains from patients X and Y and clade B consensus HIV-1 ... See full document
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