[PDF] Top 20 A study on the effect of <em>IL-6</em> gene polymorphism on the prognosis of non-small-cell lung cancer

... knockout IL-6 mice was abated; at the same time, IL-6 knockout mice were prone to analgesic drug ...tolerance. IL-6 genes located on chromosome 7p21 and IL-6 ... See full document

... exploration. Lung cancer has been among the earliest and most intensely studied diseases using microarray platforms ...prognostic gene expression signature for early stage lung adenocarcinoma ... See full document

... present study demonstrated that SNP rs763361 of allele T and SNP rs727088 of allele G were associated with NSCLC, and with lymph node inva- sion and clinical stage ...CD226 gene is associated with NSCLC in ... See full document

... in lung cancer progression, especially before TKIs treatment, is still being ...signal-mediated cancer stem cell-like properties resulted in an increase in the anticancer effects of ... See full document

... Primary EGFR T790M mutation occurred in 13 females and three males, ranging in age at diagnosis from 45 to 66 (mean age: 59.3) years. Of these, 93.7% (15 of 16) patients had never smoked. Three tumors were poorly ... See full document

... current study, we selected eight SNPs (rs2736098, rs2853676, rs2853677, rs10069690, rs2075786, rs2736114, rs2736122, and rs2853691) in the TERT gene from the reports focusing on the association studies of ... See full document

... Lung cancer is the most common malignancy worldwide, and the pathogenesis of this disease is still ...in lung cancer has promoted substantial interest. IL-18 is a pleiotropic ... See full document

... fusion gene and its association with clinicopathologic factors in 694 patients with NSCLC with identified EGFR ...fusion gene as an oncogenic driver may be more important in NSCLC than what we ...our ... See full document

... knockdown effect against a specific gene (HSPA5 or ...significant effect and balanced performance between both cell lines were selected for the following experiment (HSPA5: si-2082 and EEF2: ... See full document

... breast, lung, brain, and liver, and also on the presence of KIF23 mutations in melanoma and colorectal ...KIF23 gene causing a rare hereditary form of dyserythropoietic anemia (CDA III) with predisposition ... See full document

... current study should be acknowl- ...fine-mapping study should be conducted to further study the potential relationship of GF2BP2 and IGFBP3 polymor- phisms with risk of ...case–control study, ... See full document

... T869C polymorphism among the cases were in HWE. TGFB1 T869C polymorphism results in a Leu10Pro substitu- tion in the hydrophobic core of signal peptide (Figure ... See full document

... (rs776746) polymorphism has a direct impact on CYP3A5 activity, and people are either functional expressers of CYP3A5, carrying at least one CYP3A5*1 allele, or are functional nonexpressers if they have the mutant ... See full document

... Data extraction was performed using a standardized data- extraction form, collecting information on the first author’s name, publication year, median age, patient number, stage, histology, differentiation, detection ... See full document

... UGT1A1 gene polymorphism has the closest relationship to irinotecan adverse event, further analy- sis was performed and the result shows that only ...UGT1A1*28 gene polymorphism and diarrhea ... See full document

... One hundred twelve NSCLC patients and 80 healthy controls were genotyped for rs11077 polymorphisms with ligase detection reaction method. The rs11077 CC (carrying two homozygous C alleles), AC (carrying heterozygous A ... See full document

... In our present work, 12 up-regulated genes were ultimately included for further analysis in the aspects of biological function (biological process, cellular component, molecular func- tion) and the KEGG pathway. These ... See full document

... this study from the Zhejiang Cancer Hospital, People’s Republic of ...The study was approved by the Medical Ethical Committee of Zhejiang Cancer Hospital, and the patients signed the informed ... See full document

... The prognosis of small-cell lung cancer (SCLC) is poor despite reports suggesting modest improvement in ...the prognosis of SCLC. For instance, the therapeutic effect of ... See full document

... of IL-1A rs3783553 polymorphism on cancer ...meta-analysis study should be ...of gene–gene and gene– ...was small, which may result in potential publication bias, ... See full document