[PDF] Top 20 A study of the nitroprusside anion and some of its analogues

... Johnson f ir s t d e scribed th e hypotensive action o f sodium nitropr u ssid e in 1929, but i t was th e mid 1960*s befor e i t became e stablished as the potent rapid acting vasodilator used in anae sth e sia as a ... See full document

... docking of ATP. Through the docking studies, the model structures of the ligand–receptor complex were obtained. The docking results indicated that conserved amino acid residues in CDK10 played an important role in ... See full document

... of its novel analogues starting from gastrodigenin (4- hydroxybenzyl alcohol) through simple multi- step synthetic routes and to study their preliminary cytotoxic effect on four cancer cell lines, ... See full document

... arylthio analogues, 14‐16, and the 4‐thio derivatives 19‐25 has been ...others analogues shown moderate to poor ...modeling study showing its binding to the reverse transcriptase enzyme pocket ... See full document

... e1 and z1 is characterized by one imaginary frequency (180i cm -1 ), which corresponds to rotation around the (O)C–N(O) bond. The relatively high rotational energy barrier of 51.1 kJ mol -1 is due to the loss of ... See full document

... commercialized in its racemic form, however literature observations suggested that the biological activity of 1a resides in the R enantiomer. According to legislation already approved in many countries of the ... See full document

... and its recep- tors of wound in hyperglycaemic rats (Mani et ...vivo study curcumin improves the muscle regeneration through modu- lating the NF-κB activity during trauma (Thaloor et ... See full document

... present study eleven selenium containing nucleoside analogues of pyridine, pyridazine and quinoline derivatives were subject to in vitro and in vivo antioxidant ... See full document

... directly attached to one of the phenolic positions. Further- more, in order to understand the structural feature that makes a compound an effective lipophilic antioxidant, we have measured the radical-scavenging capacity ... See full document

... present study we have screened benzophenone derivatives 5a-k against six bacterial species viz gram positive (Bacillus subtilis and Staphylococcus aureus) and gram negative (Pseudomonas aeruginosa, Salmonella ... See full document

... the study of synthetic pyrethroids, a special emphasis is placed on the elaboration of new production technologies, including the isolation of diastereomers and enantiomers, which allows one to reduce the applied ... See full document

... 2.745 (s, 6H, ‑N(CH 3 ) 2 ), 6.348‑7.489 (m, 7H, aromatic), 8.670 (s, 1H, 3‑OH), 12.895 (s, 1H, 7‑OH). The cell lines were grown in Roswell Park Memorial Institute (RPMI) 1640 medium containing 10% foetal bovine serum ... See full document

... to its superior safety ...II study that addition of clarithromycin to lenalido- mide and dexamethasone (BiRD) results in a higher over- all response rate ... See full document

... present study, we deigned a series of N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides derivatives based on reported pharmacophore as HIV-integrase enzyme inhibitor and synthesized by reaction of ... See full document

... mobile phase A and 99% mobile phase B at 10.0 minute. This mobile phase maintained to 11.5 minute, and then re-equilibrated back to the initial conditions for the next injection with a total runtime of 15.5 minutes. The ... See full document

... Phloridzin, an important bioactive compound of apple peel, is gaining greater attention owing to its larger effectiveness as strong anti-microbial agent. This bioactive moiety shows greater anti-microbial activity ... See full document

... Materials: All chemicals were obtained from Sigma-Aldrich or Alfa Aesar and were used as received except for 1-methylimidazole, which was distilled over calcium hydride prior to use. All ionic liquids investigated in ... See full document

... N-4,6-pyrimidine-N-alkyl-N0-phenyl urea scaffold is described. Many of these compounds showed low- nanomolar inhibition of lck kinase activity as well as IL-2 synthesis from Jurkat cells. One of these analogs, 7i, was ... See full document

... this study, the stability of the sp 2 carbanion derived from arenes and olefins during the reversible O to C(sp 2 ) Brook rearrangement, not surprisingly, proved less favorable compared to the C(sp 3 ) dithiane ... See full document

... as its method of synthesis, pharmacological uses and recent ...and its analogues have been reported in literature, but study showed that the antimicrobial and anticancer activities are of ... See full document