[PDF] Top 20 The PACE Study: A randomised clinical trial of cognitive activity (CA) for older adults with mild cognitive impairment (MCI)

... the PACE study was a diagnosis of MCI, which was ascertained at a screening assessment at the WACHA (discussed in further detail ...notable cognitive impairment, as evi- denced by a ... See full document

... with MCI or early dementia (Montreal Cognitive Assessment score 13 – 25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the ... See full document

... whilst more intensive supervision will be more expensive but may be more effective [34–36, 48, 57]. The decision to choose one arm or the other, or how to tailor supervision according to individual circumstances, in a ... See full document

... with MCI are still independ- ent in most of the activities of daily living, more than 30% of caregivers of persons with MCI report experiencing a clinically significant burden [47] and their needs for ... See full document

... drug study; (4) his- tory in the past 2 years of epileptic seizures (participants with epilepsy who have been stable off medication or seizure free for 2 years may be included); (5) any major psychiatric disorder ... See full document

... Participants randomised to the electroacupuncture group will receive electroacupuncture stimulation after baseline ...of clinical acupuncture ...of MCI; thus, each participant will receive ... See full document

... other cognitive deficits, while phlegm and blood stasis are significant pathological ...against cognitive decline, involving, ...improving cognitive function in clinical practice without ... See full document

... in older women with MCI ...neuroimaging study using near infrared spectroscopy, patients with AD showed decreased brain activation patterns compared with healthy controls dur- ing the conduct of ... See full document

... cohort study of mild cognitive impairment (MCI) and mild-moderate Alzheimer ’ s disease (AD) community-dwelling ...on clinical measures, muscle mass and physical ... See full document

... and CA sessions using a sequential de- sign; 29 studies used a simultaneous design and three studies had both sequential and simultaneous compo- ...+ CA interven- tions consisted of exergames (n = 6), dance ... See full document

... on Cognitive Decline in the Elderly (Short-Form IQ Code) [20] is an informant based, brief cognitive screen- ing questionnaire for individuals with ...s cognitive abilities as they apply to everyday ... See full document

... ameliorate cognitive decline in aging, this pilot study was conducted to evaluate the feasibility and outcomes of long-term, in-home use of a neuro-exergame for older ...pilot trial with ... See full document

... or cognitive task; however, if a participant stopped either task during the trial they were prompted to con- ...and cognitive task, has previously been shown to better represent the dynamics of daily ... See full document

... the general population leads to higher dementia morbidity. Cardiovascular risk factors have cumulative effects and arterial hypertension has the most significant role. Thus, the brain as a target organ is subjected to ... See full document

... diagnose MCI. This test helps to distinguish MCI group from healthy con- ...same cognitive domains as in the original MoCA: orienta- tion, executive function, language, conceptual thinking, ... See full document

... AD pathogenesis is a complex process involving both genetic and environmental factors. Current pharmacotherapy of AD relies on the symptomatic effects of anticholinesterases and NMDA-receptor antagonists; it does not ... See full document

... of cognitive processes with improved performance on spatial (Erickson et ...and cognitive performance is strong, the empirical evidence is weak (McMorris, ...current study, serum BDNF concentration ... See full document

... for MCI, but also distinguish between mild and moderate AD, which had never been reported ...in clinical work as a quick and sensitive screening tool to distinguish different severities of ... See full document

... The exact mechanisms by which aerobic exercise and vitamin supplementation may affect cognition are not yet known and some overlap between the hypothesized mechanisms may exist in terms of ‘vascular changes’. In theory, ... See full document

... Normal distribution of data was checked with the Shapiro–Wilk test. Correlations among the three out- comes were explored using Pearson and Spearman correlations coefficients. Multiple regression analysis was performed ... See full document