[PDF] Top 20 Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes
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Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes
... E protein DIII in ...E protein was amplified from a DENV-2 strain 16681 infectious cDNA clone (35) by PCR, with BamHI and XhoI sites added at the 5 ⬘ and 3 ⬘ ends, ...containing 2% glucose. ... See full document
11
Recombinant Dengue Type 2 Viruses with Altered E Protein Domain III Epitopes Are Efficiently Neutralized by Human Immune Sera
... with dengue and West Nile virus are not mainly directed to well-studied neutralizing anti- body epitopes on EDIII (20, 27, ...recombinant protein antigens and the native protein ... See full document
5
Structure and Function Analysis of Therapeutic Monoclonal Antibodies against Dengue Virus Type 2
... A-strand epitopes in DIII as targets of type- and subcomplex-specific MAbs against DENV-2 with strongly neutralizing activity (16, 17, 30, 33, 47, 57, 61) and the fusion ... See full document
13
Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain II
... the envelope (E) glycoprotein of dengue virus (DENV) is known to play a critical role in both protection from and enhancement of disease, especially after primary ...anti-E antibodies and ... See full document
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Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein
... known type- and group-specific epitopes poses the follow- ing ...Are antibodies that recognize epitopes con- served among serotypes ...in domain II) also cross- ... See full document
9
Monoclonal Antibodies That Bind to Common Epitopes on the Dengue Virus Type 2 Nonstructural-1 and Envelope Glycoproteins Display Weak Neutralizing Activity and Differentiated Responses to Virulent Strains: Implications for Pathogenesis and Vaccines
... by neutralizing DENV type or complex as well as by flavivirus subgroup and group, have been located within the E ...These epitopes were identified by either the generation of escape mutations (13, ... See full document
13
The Chimeric Protein Domain III-Capsid of Dengue Virus Serotype 2 (DEN-2) Successfully Boosts Neutralizing Antibodies Generated in Monkeys upon Infection with DEN-2
... attenuated dengue virus strains in our laboratory (Center for Genetic Engineering and Biotechnol- ogy, Havana, Cuba), in this work we used the replicative virus as a model of attenuated virus ... See full document
5
A NOVEL TETRAVALENT RECOMBINANT ENVELOPE DOMAIN III VACCINE AGAINST DENGUE: AN IN SILICO APPROACH
... no specific treatment (antivirals) or licensed vaccine present in the market to date 5 ...by neutralizing antibodies 6, 7 ...of dengue has also been documented 8, 9 . Envelope ... See full document
10
Genotype-Specific Neutralization and Protection by Antibodies against Dengue Virus Type 3
... Protection against DENV is associated with the development of neutralizing antibodies that recognize the viral envelope (E) ...monoclonal antibodies (MAbs) that can function as ... See full document
14
A Mouse Monoclonal Antibody against Dengue Virus Type 1 Mochizuki Strain Targeting Envelope Protein Domain II and Displaying Strongly Neutralizing but Not Enhancing Activity
... was specific for DENV-1, IgG1 subclass member 3H12 was cross-reactive with DENV-2 to DENV-4 (Ta- ble ...of neutralizing and enhancing activities against DENV-1 ...only neutralizing and ... See full document
10
Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 Virus
... of virus infectivity neutralized at particular relative occupancy levels) for the DENV complex-specific MAbs in this study was considerably less compared to previous data for a panel of DENV-2 ED3 ... See full document
10
Analysis of Individuals from a Dengue Endemic Region Helps Define the Footprint and Repertoire of Antibodies Targeting Dengue Virus 3 Type Specific Epitopes
... DENV envelope (E) protein is the major target of neutralizing antibodies (6), and its ectodomain is comprised of three domains: EDI, EDII, and ...facilitates virus attachment to host ... See full document
14
Comparison of Plaque- and Enzyme-Linked Immunospot-Based Assays To Measure the Neutralizing Activities of Monoclonal Antibodies Specific to Domain III of Dengue Virus Envelope Protein
... anti-dengue virus (DENV) antibodies, but it is time-consuming and labor-intensive and has low sample ...of neutralizing antibodies, especially in evaluating the efficiency of the DENV ... See full document
6
Neutralizing and non neutralizing monoclonal antibodies against dengue virus E protein derived from a naturally infected patient
... which virus envelope glycopro- teins are immobilized in wells coated with Concanavalin A (ConA) a plant lectin that binds carbohydrate moi- eties on glycoproteins of a variety of enveloped viruses ...that ... See full document
11
Infection-Enhancing and -Neutralizing Activities of Mouse Monoclonal Antibodies against Dengue Type 2 and 4 Viruses Are Controlled by Complement Levels
... cause dengue fever and its severer form, dengue hemorrhagic ...While neutralizing antibodies are considered to play a major role in protection from these diseases, antibody-dependent ... See full document
11
Improved Induction of Antibodies against Key Neutralizing Epitopes by Human Immunodeficiency Virus Type 1 gp120 DNA Prime-Protein Boost Vaccination Compared to gp120 Protein-Only Vaccination
... broadly neutralizing monoclonal antibod- ies (MAbs) that target conserved regions of Env have been identified (3, 4, ...these antibodies, 2G12 and immu- noglobulin G1b12 (IgG1b12 [b12]), recognize ... See full document
10
Role of Human Immunodeficiency Virus Type 1 Envelope Structure in the Induction of Broadly Neutralizing Antibodies
... in heavy chain CDR1, CDR2, and CDR3. A cryo-electron microscopic analysis of bind- ing characteristics revealed that VRC01 and VRC02 act as partial CD4 agonists in their binding with gp120 and partially mimic the ... See full document
12
Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein.
... We now present data showing that on the basis of fractionation of infected macaque sera, protease digestion of the envelope, and binding properties of two neutralizing monoclonal antibod[r] ... See full document
8
Characterization and epitope mapping of Dengue virus type 1 specific monoclonal antibodies
... develop neutralizing monoclonal antibodies (mAbs), BALB/c mice were immunized with UV-inactivated DV1 viral particles and then boosted with recombinant DV1 E395 ...E395 protein and DV1 infected C6/36 ... See full document
11
Monoclonal Antibodies Directed against Conserved Epitopes on the Nucleocapsid Protein and the Major Envelope Glycoprotein of Equine Arteritis Virus
... arteritis virus (EAV) is the etiological agent of equine viral arteritis (EVA), a respiratory and reproductive disease that affects horses throughout the world ...the virus has occasionally been associated ... See full document
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