[PDF] Top 20 FoxO1 Suppresses Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency
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FoxO1 Suppresses Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency
... Kaposi’s sarcoma-associated herpesvirus (KSHV) has latent and lytic rep- lication phases, both of which contribute to the development of KSHV-induced ma- ...KSHV latency and induce ... See full document
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The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic Replication
... of lytic cycle genes was diminished up to 80% in the presence of a K1 dominant negative mutant, which inhibited wild-type K1 signal transduction in BCBL-1 cells that were induced into reactivation by the ectopic ... See full document
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Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
... Many viral proteins, such as NS1 of influenza virus (43), VP35 of Ebola Zaire virus (44), and ICP0 of herpes simplex virus 1 (45), perform multiple ...for viral lytic ...KSHV lytic repli- ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication
... Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) RTA is an important protein involved in the induction of KSHV lytic replication from latency ... See full document
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Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis
... RTA lytic switch protein following reactivation with the HDAC inhibitor valproic acid (VPA) ...from latency in both the ...the viral genome in both cell models without affecting RTA mRNA ... See full document
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Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
... USA Kaposi sarcoma–associated (KS-associated) herpesvirus (KSHV) infection is linked to the development of both KS and several lymphoproliferative ...latent viral infection. KS ... See full document
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Activation of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Lytic Replication by Human Cytomegalovirus
... Analysis of the recombinant cells with the 4.8-kb probe showed both a wild-type pattern of fragments and additional, higher- molecular-weight fragments. The wild-type-sized fragments were expected to be present since it ... See full document
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Evaluation of the Lytic Origins of Replication of Kaposi's Sarcoma-Associated Virus/Human Herpesvirus 8 in the Context of the Viral Genome
... A somewhat surprising result is the failure of the BAC with oriLyt-L deleted to support viral replication. The deletion of oriLyt-L also removes an identified open reading frame within this region (17). ... See full document
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Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy
... since viral replication is the result of error-correcting, DNA-dependent DNA polymerases (the cellular DNA polymerase during latency and a viral KSHV-encoded DNA polymerase during lytic ... See full document
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Enhancement of Autophagy during Lytic Replication by the Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator
... (Kaposi’s sarcoma-associated herpesvirus) life ...KSHV lytic reactivation from latency, and an enhancement of autophagy can be detected during KSHV lytic ...essential ... See full document
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Transcriptional Downregulation of ORF50/Rta by Methotrexate Inhibits the Switch of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 from Latency to Lytic Replication
... Cytokine assay. Assays were done by enzyme-linked immunosorbent assay in a commercial laboratory (Cytokine Core Laboratory, Baltimore, Md.). RESULTS MTX dose-response curve on ORF50/Rta mRNA levels. To study the effect ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency
... 7B). The construct comprising the central region of LANA showed no binding (data not shown). LANA colocalizes with Rta when transiently transfected in human cells and in KSHV-positive cells induced for lytic rep- ... See full document
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Acetylation of the Latency-Associated Nuclear Antigen Regulates Repression of Kaposi's Sarcoma-Associated Herpesvirus Lytic Transcription
... RRV lytic replication by inhibiting ORF50/Rta transcription activation ...other lytic genes dependent on the ORF50 protein ...expression suppresses and delays lytic cycle gene ... See full document
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Activation of p90 Ribosomal S6 Kinase by ORF45 of Kaposi's Sarcoma-Associated Herpesvirus and Its Role in Viral Lytic Replication
... of viral gene expression, because UV- irradiated KSHV also activates ERK1/ERK2 ...with viral gene expression. Although other viral factors could also be involved, we demonstrated that ORF45 ... See full document
13
β-Adrenoreceptors Reactivate Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication via PKA-Dependent Control of Viral RTA
... transcription factor. Kinase-mediated posttranslational modi- fication of RTA could explain why PKA activates KSHV lytic promoters more strongly in PEL cells than in similar B lym- phoid cells lacking endogenous ... See full document
10
The Latency-Associated Nuclear Antigen Homolog of Herpesvirus Saimiri Inhibits Lytic Virus Replication
... of lytic replication in A549 cells ...of lytic replication of HVS in the standard permissive cell culture ...of viral genomes and to identify viral or cellular molecules that ... See full document
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Induction of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen by the Lytic Transactivator RTA: a Novel Mechanism for Establishment of Latency
... is associated with KSHV virions and is likely to be located in tegument, it is possible that RTA present in the virions may immediately influence viral gene expression upon entry of the virion ...of ... See full document
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Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication
... The latency-associated nuclear antigen (LANA) of the Kaposi’s sarcoma- associated herpesvirus (KSHV) performs a variety of functions to establish and main- tain KSHV ...During ... See full document
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Quantitative Analysis of the Bidirectional Viral G-Protein-Coupled Receptor and Lytic Latency-Associated Nuclear Antigen Promoter of Kaposi's Sarcoma-Associated Herpesvirus
... This report demonstrates a competitive relationship between the two TATA elements. This is reflected in a decreased efficiency for each TSS in the bidirectional reporter relative to the single- reporter-only input ... See full document
13
Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Contains Two Functional Lytic Origins of DNA Replication
... Table 1 shows the names, nucleotide coordinates, and re- striction sites used for subclones that were made and subse- quently transfected into BCBL-1 cells (AIDS Research and Reference Reagent Program). We initially ... See full document
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