[PDF] Top 20 Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences
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Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences
... the influenza virus poly- merase complex has been described to be highly dynamic, adopting different conformations (5, ...of PB1 and the C-ter- minal domain of the PA protein has been established as ... See full document
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Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation
... the polymerase or an earlier step of the virus ...of polymerase activity for the ts mutations was observed at 37°C (and ...the virus mutants was only identified at ...RNA polymerase ... See full document
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Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System
... potentially targeting PPIs, we selected three subsets (using similarity, machine learning methods [MLM], and the Rule of Four) for virtual ...the interface of PB1c and PB2n with a search space size of 18Å ... See full document
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Host and Strain Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins
... of virus released 20 h ...by influenza A/VN/1203/04 (H5N1) HALo virus (MOI ⫽ ...HALo virus (MOI ⫽ ...P12 indicates both pooled, targeting PARP1; DDX17, siRNA pool ... See full document
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The Effects of Influenza A Virus PB1-F2 Protein on Polymerase Activity Are Strain Specific and Do Not Impact Pathogenesis
... ⌬ PB1-F2 construct led to significantly lower polymerase activity than that of WT PR8, as did substitution of the truncated Beij PB1-F2 ...1918 PB1-F2, which is linked to in- creased virulence ... See full document
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Defective Assembly of Influenza A Virus due to a Mutation in the Polymerase Subunit PA
... RNA polymerase of influenza A virus is composed of three subunits that together synthesize all viral mRNAs and also replicate the viral genomic RNA segments (vRNAs) through intermediates known as ... See full document
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The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix
... of PB2 with MAVS is not a determinant of its mitochondrial association; PB2 of seasonal hu- man influenza viruses shows the same pattern of mitochondrial localization in MAVS knockout cells as in ... See full document
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Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans
... A PB2-UPS interaction map encompassing all of the strains tested was plugged into the human interactome recovered from the BioGRID PPI ...the PB2 targets interact with each other ...where PB2 binds ... See full document
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Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice
... Viral polymerase plays a crucial role in controlling the expres- sion of the viral and host genomes, as well as viral ...avian influenza H5N1 viruses have shown that virulence in mammals is directly ... See full document
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Involvement of Influenza Virus PA Subunit in Assembly of Functional RNA Polymerase Complexes
... of influenza type A viruses consists of a set of eight single-stranded RNA segments of negative ...RNA polymerase complex. The RNA polymerase complex consists of three subunits, polymerase ... See full document
Molecular Changes in the Polymerase Genes (PA and PB1) Associated with High Pathogenicity of H5N1 Influenza Virus in Mallard Ducks
... H5N1 virus to chickens and to humans in Thailand corresponded to the distribution of free-grazing ducks ...H5N1 virus in apparently healthy ducks and geese dur- ing most months of 2004 and 2005 in southern ... See full document
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Avian Influenza A Virus Polymerase Association with Nucleoprotein, but Not Polymerase Assembly, Is Impaired in Human Cells during the Course of Infection
... MZ-WSN virus, which was not visible in 293T cells infected with the P908-WSN virus and which could correspond to NP aggregates ...of PB2 modulates the efficiency of NP binding to the Pol in human ... See full document
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H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells
... of PB1-F2-specific interactors, we first excluded proteins precipitated from cells transfected with empty vector (see Table S2 in the supplemental material [based on area ...score indicates the number of ... See full document
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The Temperature-Sensitive and Attenuation Phenotypes Conferred by Mutations in the Influenza Virus PB2, PB1, and NP Genes Are Influenced by the Species of Origin of the PB2 Gene in Reassortant Viruses Derived from Influenza A/California/07/2009 and A/WSN/33 Viruses
... 10. Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke ... See full document
9
Involvement of Hsp90 in Assembly and Nuclear Import of Influenza Virus RNA Polymerase Subunits
... for influenza virus polymerase subunits, cDNAs corresponding to the full-length PB1, PB2, PA, PB1 with a FLAG tag at its C terminus (PB1cFLAG), PB2 with a hemagglutinin ... See full document
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NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in Chickens
... of influenza virus ...using specific primers for each influenza virus ...2-week-old specific- pathogen-free White Leghorn chickens (Gallus gallus domesticus) (from SEPRL in-house ... See full document
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A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages
... laboratory strain A/WSN/1933 (H1N1) (WSN) at a multiplicity of infection (MOI) of ...of virus stocks determined using MDCK ...that virus titers in MDM culture supernatants were up to 100-fold reduced ... See full document
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Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus
... of PB2 amplicons from the respiratory tract tissues of mice infected with the VN1203 virus retained K at PB2-627 over the 7 days ...to PB2-627K was apparent by day 6 ...infectious virus ... See full document
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Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses
... A virus, we used reverse genetics to generate (25) in a PR8 backbone recombinant viruses containing the NS1 open reading frame (ORF) of the PR8 wild type (WT) (for comparison purposes), the NS1 ORF of HL17NL10, ... See full document
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A Replication-Incompetent PB2-Knockout Influenza A Virus Vaccine Vector
... cubated with 2-fold serial dilutions of receptor-destroying enzyme- treated sera for 30 min at 33°C, and the mixtures were added to confluent MDCK cells on 96-well microplates to determine the neutralizing activity. IFA ... See full document
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