[PDF] Top 20 Targeting noncoding RNAs in disease

... these RNAs in ...gene targeting within certain tissues (39, 40). Targeting moieties can also be directly conjugated to the ORN, such as N-acetylgalactosamine (GalNAc) for delivery to hepa- tocytes in ... See full document

... Materials and methods: Three patients with PD and three normal controls were enrolled in the present study from July 12, 2017, to August 29, 2017. RNA sequencing and bioinformatics analy- sis were performed to obtain ... See full document

... and disease-free survival ...non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding ... See full document

... Mitochondria have distinct genetic systems that need to be coordinated with the nuclear genetic system, to meet the cellular energy and metabolite needs [5]. In the coordinated signaling system, many proteins encoded by ... See full document

... The field of research exploring ncRNAs in MS, how- ever, requires further attention, particularly for confirm- ation before the findings can be translated to clinical applications; this is especially the case for the ... See full document

... a disease which is diagnosed by its typical symptoms and imaging findings of atrophic pancreas or pancreatic calcification through CT-scan, MRCP, ERCP ...the disease has already been progressed to late ... See full document

... a disease that affects infants and despite intense multimodal therapy, high-risk patients have low survival rates ...long noncoding RNAs (lncRNAs) have become the cutting edge of cancer research with ... See full document

... An increasing number of ncRNAs are being reported to be aberrantly expressed in CRC, and differential expression of ncRNAs can be detected in the circulation of CRC patients. Importantly, ncRNAs are abundant and their ... See full document

... “noncoding RNAs” (ncRNAs) are a group of RNAs that do not code for proteins, and they are categorized as structural RNAs and regulatory ...regulatory RNAs to affect the progression of ... See full document

... compared to healthy donor thymocytes. MiR-128-3p dir- ectly inhibits the expression of the tumor suppressor PHF6 and overexpression caused accelerated leukemia onset in the NOTCH1-sensitized mouse model [99]. MiR-21 is ... See full document

... these features to test some of the proposed rolesand characteristics of lincRNAs in a global and systematicway. For example, we found that lincRNAs—at all expressionlevels—are expressed in a highly ... See full document

... and targeting the abnormal expression level of PTEN is anticipated to offer novel therapeutic ...Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is ... See full document

... As a broad concept, lncRNAs encompass a few types of RNA transcripts. According to their location in the genome, lncRNAs can be classified into seven broad cat- egories as following: (a) sense lncRNAs, (b) antisense ... See full document

... intervening noncoding RNAs (lincRNAs), transcribed from intergenic regions that do not overlap any mRNAs, have been the subject of much research in mammalian cells (Rinn and Chang 2012; Ulitsky and Bartel ... See full document

... The precise mechanisms whereby lncRNAs enforce transcriptional silencing are not well understood; therefore, even the question of whether lncRNAs act predomi- nantly in cis or in trans has become contro- versial. Many ... See full document

... increasing disease severity and developed pneumonia FIG 3 Validation of the ␥ HV68 TMER-TKO RNA analysis of WT and TMER-TKO virus-infected samples demonstrates that the TMER-TKO virus completely and specifically ... See full document

... therapies targeting DNA methylation or histone methylation modification could be result from direct tumor suppressor functions and the reversed expression of TSLNRs, which also function as effective antitumor ... See full document

... the targeting of HULC by β - elemene (a compound derived from the herb Curcuma wenyujin) can effectively suppress cell growth and induce apoptosis in ...The targeting of TUG1 by gene knockdown can signi fi - ... See full document

... through targeting phosphatase and tensin homolog deleted on chromosome 10 (PTEN), activating AKT and ERK1/2 pathways, and upregulating HIF-1α and VEGF expression [113, ... See full document

... Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 ...Alzheimer’s disease is a neurodegenerative disease, which accounts for ...Alzheimer’s disease and ... See full document