[PDF] Top 20 Targeting SOD1 reduces experimental non–small cell lung cancer
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Targeting SOD1 reduces experimental non–small cell lung cancer
... induces cell death and anchorage-independent growth impairment in human NSCLC ...ited SOD1 enzyme activity (Figure 1A) without having an effect on other copper-dependent enzymes like cytochrome C oxidase ... See full document
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Small interfering RNA targeting S100A4 sensitizes non-small-cell lung cancer cells (A549) to radiation treatment
... target cell damage occurs when an ionizing particle breaks through the DNA double strand breaks), and β (the probability of target cell damage occurs when two ionized particles break through the DNA double ... See full document
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miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc
... in cancer cells is frequently used as a cellular model to study the molecular mechan- ism of cancer proliferation, but its interaction with the expression signature of miR-145 is not completely ... See full document
10
MiR-195 suppresses non-small cell lung cancer by targeting CHEK1
... University Cancer Hospital (TMUCH) between May, 2006 and July, ...confirmed non-small cell lung cancer ...or non-tumor tissues, and were stored at −80°C until ...of ... See full document
12
Novel classes of non coding RNAs and cancer
... of small ncRNAs involved in post- transcriptional RNA silencing are so-called small inter- fering RNAs ...promising experimental tool in molecular oncology. SiRNAs could be used in cancer ... See full document
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<p>Targeting RET-rearranged non-small-cell lung cancer: future prospects</p>
... overall response rates than patients with other RET fusions. Recently, through other in vitro experiments, some missense RET mutations have been found associated with resistance to cabozantinib, lenvatinib, and ... See full document
10
miR-1238 inhibits cell proliferation by targeting LHX2 in non- small cell lung cancer
... Although there are more and more evidence showing that LHX2 is frequently up-regulated in human cancers [6-8, 23], the mechanisms underlying the increased expression of LHX2 are poorly understood. In this study, we ... See full document
12
Crizotinib in non small cell lung cancer
... The Crizotinib has been tested in patients with metas- tatic NSCLC, the tumor which has a genetic defect on chromosome 2, resulting in the fusion of two genes, ALK and EML4 (echinoderm microtubule-associated protein- ... See full document
5
Original Article MiR-498 inhibits cell migration and invasion by targeting WT1 and predicts better prognosis in non-small cell lung cancer
... Total RNA from tissue samples and cell lines were isolated with TRIZOL reagent (Invitrogen) according to the manufacturer’s protocol; qRT- PCR was used to validate microarray data. Each miRNA was specifically ... See full document
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Prognostic value of metformin for non small cell lung cancer patients with diabetes
... of small cell lung cancer (SCLC), found that metformin significantly reduced the recurrence rate of SCLC ( p = ...and experimental studies confirmed that metformin had the anti-tumor ... See full document
5
Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
... aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe ... See full document
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Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer.
... It is important to note that EGFR exon 20 insertion mutations are heterogeneous and that the location of the insertion, in particular, may in fl uence the kinetics of drug and ATP binding, ultimately determining ... See full document
10
Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer
... NSCLC cell lines H1299, H460, Calu1, and A549, and one cultured lung epithelial cell BEAS-2B were purchased from American Type Culture Collection and cultured in DMEM (GIBCO BRL, Grand Island, NY, ... See full document
9
Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer
... This study revealed for the first time that elevated tumor PDPN expression on both the mRNA level and the protein level has a significant impact on clinicopathological features (pleural invasion, LVI, and lymph node ... See full document
12
GE11-modified liposomes for non-small cell lung cancer targeting: preparation, ex vitro and in vivo evaluation
... In the present study, a series of doxorubicin-loaded lipo- somes containing GE11 of varying density was successfully prepared, and modification by GE11 did not impact the characteristics of the liposomes, including size ... See full document
15
Vaccines in Non Small Cell Lung Cancer
... 80%. Non-small cell lung cancer stage IIIB and IV patients were enrolled between 2000 and 2002 by centers of Canada and the United Kingdom, including a total of 171 ...a ... See full document
6
Non-small cell to small cell lung cancer on PD-1 inhibitors: two cases on potential histologic transformation
... Discussion: Histologic transformation from NSCLC to SCLC can be explained by the pres- ence of a common cell precursor. Proposed molecular mechanisms include loss of RB1, TP53 mutations, and MYC amplification. The ... See full document
6
An adherent subline of a unique small cell lung cancer cell line downregulates antigens of the neural cell adhesion molecule
... Small-cell lung cancer (SCLC) lines are distinguished from non-small-cell lung cancer (NSCLC) lines by their growth in floating aggregates, in contrast to ... See full document
8
Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
... SCLC lung cancer cell line using both in vitro and in vivo ...SCLC cell line. TQ inhibited pro- liferation of NSCLC cell line NCI-H460 and induced ...Similarly cell viability of ... See full document
11
Video assisted thoracic surgery vs. thoracotomy for locally advanced lung squamous cell carcinoma after neoadjuvant chemotherapy
... stage lung can- cer, but in recent years it has been carried out by some experienced thoracic surgeons in LANSCLC with satis- factory outcome [10, ...on Cancer (AJCC 8) staging ... See full document
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