Top PDF Targets of Small Interfering RNA Restriction during Human Immunodeficiency Virus Type 1 Replication
Targets of Small Interfering RNA Restriction during Human Immunodeficiency Virus Type 1 Replication
... genomic RNA but not the incoming HIV-1 genomic RNA, suggesting that this protection from siRNA degradation is related to viral ...capsid. During coevolu- tion of pathogen and host, various ...
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RNA Interference Directed against Viral and Cellular Targets Inhibits Human Immunodeficiency Virus Type 1 Replication
... Human immunodeficiency virus type 1 (HIV-1) gene expression is regulated by both cellular transcription factors and ...TAR RNA in conjunction with cyclin T1 and ...
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Lentiviral Vectors Interfering with Virus-Induced CD4 Down-Modulation Potently Block Human Immunodeficiency Virus Type 1 Replication in Primary Lymphocytes
... role during human immunodeficiency virus (HIV) ...However, during late stages of infection, the viral receptor exerts inhibitory effects on the infectivity of the released particles ...
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Endoribonuclease-Prepared Short Interfering RNAs Induce Effective and Specific Inhibition of Human Immunodeficiency Virus Type 1 Replication
... esiRNAs generated by Dicer more efficiently inhibit HIV-1 replication. To establish an alternative method for generating esiRNA libraries, we explored the ability of the enzyme Dicer to substitute for the ...
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Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC
... the human immunodeficiency virus type 1 (HIV-1) was first isolated 30 years ago, tremendous progress has been made in the prevention and treatment of ...novel targets and ...
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Role of Cellular RNA Processing Factors in Human Immunodeficiency Virus Type 1 mRNA Metabolism, Replication, and Infectivity
... the human immunodeficiency virus type 1 genome requires several cellular factors regulating transcription, alternative splicing, RNA stability, and intracellular localization of ...
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Rab9 GTPase Is Required for Replication of Human Immunodeficiency Virus Type 1, Filoviruses, and Measles Virus
... Marburg virus-infected cells, suggesting that Rab9 is utilized in Marburg ...in human immunodeficiency virus (HIV) replication, previous reports suggested that the late endosome is an ...
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Cyclophilin A-Independent Replication of a Human Immunodeficiency Virus Type 1 Isolate Carrying a Small Portion of the Simian Immunodeficiency Virus SIVMACgag Capsid Region
... various virus clones in Fig. 1, input cell-free virus samples were prepared from transfected 293T cells and inoculated into the cell lines indicated in Table ...Three restriction enzymes ...
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Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes
... of human immunodeficiency virus type 1 (HIV-1) infections occur via mucosal contact (40), and there are several reports indicating that the oral mucosa may be one route of ...
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Susceptibility of Rat-Derived Cells to Replication by Human Immunodeficiency Virus Type 1
... HIV-1 replication in some rodent cell lines. At least one restriction in cell lines from mice and hamsters is the inability of the viral transcription regulator, Tat, to activate transcription from ...
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Inhibitory effect of small interfering RNA on dengue virus replication in mosquito cells
... potential targets for ...viral RNA and the viral replication [25]. Virus resistance has been proven to be generated by RNAi triggered from exogenous DEN-specific ...the type II dengue ...
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Sequence Homology Required by Human Immunodeficiency Virus Type 1 To Escape from Short Interfering RNAs
... the virus to escape siRNA ...its RNA genome ...C virus replicons ...a small region of high tolerability for mismatches at the 3 ⬘ and 5 ⬘ ends of the target sequence and a region of fairly low ...
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“UnPAKing” Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV Infection
... amount of  -galactosidase produced via the viral LTR pro- moter using a chemiluminescent substrate (Gal Screen). The distribution of signals from all of the siRNAs and controls is shown in Fig. 1B, where the positive ...
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Role of the DIS hairpin in replication of human immunodeficiency virus type 1.
... and RNA-packaging defect of the DIS mutants is rela- tively minor, we wanted to obtain additional evidence for the loss of infectivity of these ...produced virus stocks revealed an approximately 10-fold re- ...
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Small Molecule Targets Env for Endoplasmic Reticulum-Associated Protein Degradation and Inhibits Human Immunodeficiency Virus Type 1 Propagation
... the replication of all 47 HIV-1 laboratory strains and clinical isolates examined with a 50% inhibitory concentration of ⬃ 10 M, a concentration that is 200- to 2,000-fold less than what affected cell ...
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Antiviral Effects of Human Immunodeficiency Virus Type 1-Specific Small Interfering RNAs against Targets Conserved in Select Neurotropic Viral Strains
... by small interfering RNAs (siRNAs), has been demonstrated in recent studies to be an effective strategy against human immunodeficiency virus type 1 ...viral RNA. ...
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Inhibition of -Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency Virus Type 1 Replication
... Current experimental data to support the role of hA3G deamination of DNA in either the degradation of viral DNA or in any other antiviral activity remain inconclusive. Since the deamination mutations in DNA result in the ...
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Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants
... HIV-1 replication in infants and ...HIV-1 RNA copy number following the initiation of antiretroviral therapy allowed the estimation of HIV-1 kinetic ...
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Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
... No depletion of CD4+ human thymocytes was observed in implants infected with either HIV-lJRCSF or its nef mutant at 3 or 6 weeks postinfection compared with controls consisting of mock-i[r] ...
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TAR-independent replication of human immunodeficiency virus type 1 in glial cells.
... As astrocytic glial cells supported TAR-independent gene expression from an HIV-1 LTR in subgenomic reporter constructs, we evaluated whether unstimulated astrocytic glial cells could su[r] ...
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