[PDF] Top 20 The N Terminus and C Terminus of Herpes Simplex Virus 1 ICP4 Cooperate To Activate Viral Gene Expression
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The N Terminus and C Terminus of Herpes Simplex Virus 1 ICP4 Cooperate To Activate Viral Gene Expression
... To Activate Viral Gene Expression Lauren ...most viral promoters. Two transactivation domains, one N-termi- nal and one C terminal, are largely responsible for the ... See full document
13
Requirement of the N-Terminal Activation Domain of Herpes Simplex Virus ICP4 for Viral Gene Expression
... DISCUSSION ICP4 has two discontinuous regions that are involved in the trans- activation of transcription, one N terminal and one C terminal to the DNA binding ...the C-terminal 520 amino ... See full document
9
Identification of a Motif in the C Terminus of Herpes Simplex Virus Regulatory Protein ICP4 That Contributes to Activation of Transcription
... that ICP4 residues 1 to 139 can function as a transcription activation domain when fused to the DNA binding domain of Gal4 (55) and determined that ICP4 residues 97 to 109 are essential for this ... See full document
13
Effects of deletions on expression of the herpes simplex virus thymidine kinase gene from the intact viral genome: the amino terminus of the enzyme is dispensable for catalytic activity.
... We conclude that the amino terminus of the TK polypeptide is dispensable for catalytic activity, and that expression of TK in viral infections requires some of the same promoter elements[r] ... See full document
6
The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores
... 7). By 12 h postinfection, the pattern of immunofluorescence was similar to that observed at 4 h postinfection for vFH589-infected cells, with most of the cells contain- ing capsids concentrated near or over the nuclei, ... See full document
16
The Polyserine Tract of Herpes Simplex Virus ICP4 Is Required for Normal Viral Gene Expression and Growth in Murine Trigeminal Ganglia
... the viral activities regulating gene expression may also ...protein ICP4 to viral growth in tissue culture and in neuronal and nonneuronal cells in ...the viral genomes ... See full document
10
Proteolytic Cleavage of the Amino Terminus of the UL15 Gene Product of Herpes Simplex Virus Type 1 Is Coupled with Maturation of Viral DNA into Unit-Length Genomes
... dent upon capsid association, then a U L 15-encoded protein should not be detectable in a sucrose gradient from lysates of cells infected with K23Z. As a first step in addressing this prediction, efforts were made to ... See full document
11
Herpes Simplex Virus UL12.5 Targets Mitochondria through a Mitochondrial Localization Sequence Proximal to the N Terminus
... The herpes simplex virus type 1 (HSV-1) gene UL12 encodes a conserved alkaline DNase with orthologues in all ...UL12 gene gives rise to two separately promoted 3 ⴕ ... See full document
10
Displacement of the C Terminus of Herpes Simplex Virus gD Is Sufficient To Expose the Fusion-Activating Interfaces on gD
... by herpes simplex virus (HSV) is executed and tightly regulated by four ...several viral glycopro- teins can mediate viral adhesion to host cells, only binding of gD to cellular ... See full document
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Assembly of herpes simplex virus capsids using the human cytomegalovirus scaffold protein: critical role of the C terminus.
... RESULTS Expression of HSV and HCMV scaffold proteins in Sf9 ...UL80.5 gene were ...UL80.5 gene, we constructed a truncated version of the scaffold protein ...the C-terminal 65 amino acids of ... See full document
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Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
... Thus, the effect of mutations in the tk promoter binding sites for cellular transcription factors could be directly monitored in the absence and presence of ICP4 in the context of viral [r] ... See full document
10
Repression of the alpha0 gene by ICP4 during a productive herpes simplex virus infection.
... an ICP4 binding site was introduced into the a 0 gene at the mRNA cap site in the presence or absence of the endogenous ICP4 binding ...of ICP4 to bind to this site, and the effects of this ... See full document
9
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells.
... induce expression from a restrictive chromatin envi- ronment is likely to be significant during emergence of the HSV genome from ...ICP22 expression vector did not stimulate the a-globin gene in ... See full document
10
Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4.
... The herpes simplex virus ICP4 protein is required for induction of early and late viral gene transcription as well as for repression of expression of its own gene ... See full document
11
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... I also want to thank all members of the Tscharke lab, both past and present: Stewart Smith, Inge Flesch, Michael Wong, Leon Lin, Bianca Dobson, Thilaga Velusamy, Natasha Hollett, Tijana Stefanovic, Kathryn Dickson, Erica ... See full document
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The Initiator Element in a Herpes Simplex Virus Type 1 Late-Gene Promoter Enhances Activation by ICP4, Resulting in Abundant Late-Gene Expression
... of herpes simplex virus type 1 are similar to the eukaryotic initiator sequence (Inr), have been shown to affect the levels of expression, and may also play a role in transcription ... See full document
11
The Herpes Simplex Virus Type 1 UL20 Protein and the Amino Terminus of Glycoprotein K (gK) Physically Interact with gB
... baculovirus expression system (Invitrogen). To create all the viral constructs, the pFastbac Dual vector was used, which contains two multiple-cloning sites to allow the expression of two ... See full document
11
UL31 of Herpes Simplex Virus 1 Is Necessary for Optimal NF-κB Activation and Expression of Viral Gene Products
... 31, expression of the immediate-early protein ICP4, early protein ICP8, and late protein glycoprotein C (gC) were delayed signif- ...cells, expression of these proteins failed to reach levels ... See full document
7
The C Terminus of the B5 Receptor for Herpes Simplex Virus Contains a Functional Region Important for Infection
... The expression of a previously uncharacterized human hfl-B5 cDNA confers susceptibility for herpes simplex virus (HSV) to porcine cells and fulfills criteria as an HSV entry receptor ...B5 ... See full document
7
The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.
... removed most residues between amino acids 1060 and 1235 of Pol in steps ranging in size from 17 to 45 amino acids, in the background of the large amino-terminal deletion AN960. The mutan[r] ... See full document
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