[PDF] Top 20 TGF β antagonists: Why suppress a tumor suppressor?
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TGF β antagonists: Why suppress a tumor suppressor?
... on TGF-β–induced angiogenesis. In their model, Fc:T β RII appears to decrease tumor cell intravasation and/or decrease survival of tumor cells in the circulation, since the number of ... See full document
5
Epigenetic downregulation of human disabled homolog 2 switches TGF β from a tumor suppressor to a tumor promoter
... cytokine TGF-β acts as a tumor suppressor in normal epithelial cells and during the early stages of ...to TGF-β and use this cytokine as a potent oncogenic factor; however, the ... See full document
17
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter
... has tumor suppressor activity, the mechanistic basis for this is ...Since TGF-β can act as a potent promoter of metas- tasis (2, 44) and DAB2 may be involved in TGF-β signaling ... See full document
16
TGF β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
... reduced TGF-β responsiveness and disease progression that is seen in clinical breast ...that TGF- β can switch from tumor suppressor to prometastatic factor during the course of ... See full document
10
REVIEW ARTICLE Molecular Genetics of Childhood Cancer: Implications for Pathogenesis, Diagnosis, and Treatment
... novel, tumor-specific thera- ...tivated tumor suppressors with fully functional genes or to induce leukemic cells to undergo normal differentiation and ... See full document
10
<p>Epigenetics mechanisms mediate the miR-125a/BRMS1 axis to regulate invasion and metastasis in gastric cancer</p>
... critical tumor suppressor genes and the activation of onco- genes leading to carcinogenesis, which is not accompanied by modi fi cation in the DNA ...of tumor-suppressor ... See full document
13
Original Article Effects of isorhamnetin on protein expression of VEGF, MMP-2 and Endostatin in Lewis lung cancer mouse
... ing tumor cell apoptosis and inhibiting telomer- ase activity, and can suppress the expression of P-glycoproteins for multi-drug resistance of tumors, and also can induce Lewis lung cancer cell apoptosis ... See full document
8
Original Article Baicalein inhibits the invasion, migration and epithelial-mesenchymal transition of BGC-823 cells through NF-κB/Snail signaling pathway
... which TGF-β plays its roles through tyrosine kinases [10, 22]. TGF-β can bind to its receptor to active a variety of transcription factors to induce the cadherin isoform switch by down ... See full document
7
Human four and a half LIM family members suppress tumor cell growth through a TGF β–like signaling pathway
... a TGF-b–independent manner. Casein kinase 1d, but not the TGF-b receptor, was required for the FHL-mediated TGF-b– like responses, including increased phosphorylation of Smad2/3, interaction of ... See full document
14
<p>G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer</p>
... Gastric cancer (GC) is one of the most common malignancies of the digestive tract. 1 Although the incidence of GC has decreased in recent years, its mortality rate remains high. The incidence of GC in East Asia is the ... See full document
8
Involvement of miR 214 and miR 375 in Malignant Features of Non Small Cell Lung Cancer by Down Regulating CADM1
... in tumor pro- gression by targeting a transcription factor, AP-2, and modulating various proteins implicated in cell invasion and blood vessel extravasation ... See full document
9
DNA methylation affects metastasis of renal cancer and is associated with TGF-β/RUNX3 inhibition
... Three families of runt-related genes, RUNX1 (PEBP2 B/CBFA2/AML1), RUNX2 (PEBP2 A/CBFA1/AML3) and RUNX3 (PEBP2 C/CBFA3/AML2) exist in mam- mals. All three protein families play important roles in normal developmental ... See full document
11
Original Article SOX1 suppresses cell growth and induces apoptosis by regulating Wnt/β-catenin signaling pathway in gastric cancer
... eration and apoptosis. The transfect efficiency was confirmed on both mRNA and protein lev- els (Figure 2A, 2B). Then, results of MTT assay showed that ectopic expression of SOX1 signifi- cantly inhibited GC cells ... See full document
6
TGF-β in pancreatic cancer initiation and progression: two sides of the same coin
... of TGF-β obviously increases in pancreatic cancer, and overexpression of TGF-β is associate with venous inva- sion, advanced tumor stages, progressive disease, shorter patient survival ... See full document
7
Reciprocal regulation by TLR4 and TGF β in tumor initiating stem like cells
... The TGF-β pathway is instrumental in mammalian develop- ment and tumor suppression through inhibition of proliferation and induction of ...defective TGF-β tumor suppressor ... See full document
19
Transforming growth factor β and breast cancer: Lessons learned from genetically altered mouse models
... and tumor suppressor activities of TGF-β might occur at different threshold levels of receptor ...by TGF-βs. For example, activin, a closely related TGF- β family member, ... See full document
7
The Importance of Controlling the TGF-β Signaling Pathway in the Gastric Cancer Microenvironment
... local TGF-β 1 expression and subsequent TGF-β-induced collagen deposits in several organs in patients with nonmalignant disorders such as diabetic cardiomyopathy and chronic cyclosporine ... See full document
13
Type III TGF β receptor downregulation generates an immunotolerant tumor microenvironment
... the tumor may dominate local IDO signaling, given that the TGF-β cytokine can downregulate many of these pathways (8, 13, ...of tumor-mediated regulation of TGF-β ...that ... See full document
17
Blockade of TGF β inhibits mammary tumor cell viability, migration, and metastases
... migration, tumor vascularization, interactions with the microenvironment, intravasation into blood or lymphatic vessels, and cell survival at dis- tant sites ...(1). TGF- β is a multifunctional ... See full document
10
TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells
... cartilage and inhibit synthesis of metalloproteinase inhib- itors such as TIMPs, tenascin and YKL-40. The anabolic mediators include TGF-β, IGF-1, FGFs and BMPs, which stimulate synthesis and repairing of ... See full document
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