[PDF] Top 20 The Leiden Thrombophilia Study (LETS)

... In this way the role of a deficiency of protein C, protein S or antithrombin and of APC (activated protein C) resistance, elevated von Willebrand factor and factor VIII:c levels, hyperho[r] ... See full document

... of thrombophilia peaked in the age group of 30 – 39 ...the study groups (23% in patients with thrombophilia vs 10% in ...hereditary thrombophilia varies possibly due to socio- ethnic ... See full document

... V Leiden who used oral contraceptives was 28•5 per 10 000 people (relative risk ...this study on severe Perthes’ disease (Caterall III or IV /Herrings C), 25% of our patients had more than one risk factor ... See full document

... FV Leiden mutation allele was similar among women with recurrent early miscarriage ...FV Leiden mutation in 43 women with 2 or more unexplained fetal losses and 118 ...FV Leiden mutation was more ... See full document

... prevalence of factor-V-Leiden-mutation in NoAIVC is simi- lar to the normal population. In addition, homozygosis for a common cytosine-to-thymidine mutation in the gene en- coding MTHFR, C677T, is associated with ... See full document

... A study was conducted in 2000 involving 426 Dutch patients with a first, objec- tively-diagnosed episode of DVT compared to 473 popu- lation ...This study was part of a large population- based case-control ... See full document

... This population-based, case-control study confirms that, among unselected patients, the prevalence of a (hereditary) protein C deficiency and of lowered protein S and antithrom- bin plas[r] ... See full document

... our study is its size attributable to the collaboration of several European thrombosis centers, which made the restriction to patients with 1 venous thrombotic event ...this study was an observa- tional ... See full document

... had thrombophilia, had stopped taking the com- bined contraceptive pill and hormone replacement ther- apy but had not changed their lifestyle ...V Leiden, had requested a referral to a consult- ant to ask ... See full document

... acquired thrombophilia and familial hypofibrinolysis, promoting and worsening the jaw ON [18, ...pilot study, that war- farin therapy in patients with both Factor V Leiden heterozygosity and ... See full document

... genetic thrombophilia risk factors in PVT has been investigated in several studies [17-20] but all of them have excluded cases with local risk fac- ...V Leiden, prothrombin mutation, decreased PC, decreased ... See full document

... SAEs that result in death or are life-threatening should be reported immediately. The reporting will occur not later than 7 days after the responsible investigator has first knowledge of the adverse reaction. This is for ... See full document

... predictor in a linear regression framework and using standardized age-, gender and population stratification adjusted residuals from linear regression . The summary statistics of RS-I, RS-II and RS-III were meta-analysed ... See full document

... At present, there are no functional PS assays which fulfill the requirements that can be put on an assay which is to be used m the pnmary evaluation of thrombosis patients The low specif[r] ... See full document

... def = the cumulative incidence of deep vein thrombosis or pulmonary embolism at the relevant age for subjects in the population at large, Frier = the probability to have inherited the d[r] ... See full document

... acquired thrombophilia or hypofibrinolysis. A novel finding of the current study was that, of 96 women with RVO, six (6%) first sustained RVO 3 years (on average) after beginning to take estrogens or ... See full document

... fractions, whereas a considerable increase in large, apo E-rich HDL particles also occurred. In contrast to the high expressing lines, the low expressing line 195 reacted only mildly upon HFC diet. On HFC diets, the high ... See full document

...  Complexity: The computational complexity depends on the number of viewpoints that need to be explored, the choice of transformation group and size of the signal. The matrices obtained in all of the representations are ... See full document

... The aim of the present study was to perform an analysis of the prothrombin genes of selected subjects with a history of venous thrombophilia usmg polymerase chain reaction (PCR) and dire[r] ... See full document

... this study, our preliminary findings seem to suggest an ab- normal association between PC and PS activities and duration of HD and that long-term HD patients have normal or high PC and PS activity ...this ... See full document