[PDF] Top 20 The mevalonate pathway in C. elegans
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The mevalonate pathway in C. elegans
... in C. elegans causes increased expression of cell-protective and metabolic genes as well as increased abundance of mitochondrial DNA, resulting in a slowing down of behavioral rates and extended lifespan ... See full document
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The UPRmt Protects Caenorhabditis elegans from Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway
... the mevalonate pathway, we first measured the levels of different mevalonate pathway en- zymes in vivo in ...C. elegans. We started with the first dedicated enzyme in the ... See full document
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Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts
... by centrifugation at 10,000 rpm for 10 s. The separated dodecane phase containing isoprene was analyzed using an Agilent Technologies 7890A Gas Chromatograph equipped with a flame ionization detector (FID). Briefly, 5 μL ... See full document
10
Dickkopf 1 is regulated by the mevalonate pathway in breast cancer
... immunosorbent assay and serum markers of bone turnover Human DKK-1 and murine OPG enzyme-linked immuno- sorbent assays were obtained from Biomedica (Vienna, Austria) and were performed according to the manufac- turer’s ... See full document
13
The TOR pathway interacts with the insulin signaling pathway to regulate C elegans larval development, metabolism and life span
... of C. elegans larval development, metabolism and ...either pathway will cause larval arrest at the second ...DAF-2 pathway, animals will enter the dauer ... See full document
10
Increased flux through the mevalonate pathway mediates fibrotic repair without injury
... Increasing Rac1 activity by augmenting isoprenylation promotes lung fibrosis. Because of the significant difference in mitochondrial Rac1 activity in subjects with IPF and bleomycin-injured mice, we questioned whether ... See full document
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<p>Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression</p>
... the mevalonate pathway partially, focusing on the upstream (HMGR) and down-stream (RhoA) section of the ...the pathway remain unknown, espe- cially on the production of isoprenoids such, as FPP and ... See full document
8
Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells
... Caenorhabditis elegans possesses a very unique cholesterol synthesis pathway that is deficient in its sterol synthesis branch but has the other noncholesterol intermediate ...In C. elegans, ... See full document
11
An Account of Cloned Genes of Methyl-erythritol-4-phosphate Pathway of Isoprenoid Biosynthesis in Plants
... two C 5 unit isopentenyl diphosphate (IPP) and isomer dimethylallyl diphosphate ...MEP pathway have been unravelled in plants over the past few ...MEP pathway enzymes are encoded by nuclear genes but ... See full document
12
Epsin potentiates Notch pathway activity in Drosophila and C elegans
... interaction between lqf and Notch activity. For example, we failed to detect genetic interactions between lqf and the EGF or FGF pathways during heart development, and lqf does not appear to interact with the dominant ... See full document
9
The isomiR 140 3p regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancer
... Ingenuity pathway analysis showed that the mevalonate/choles- terol biosynthesis pathway, through its key gene me- diators HMGCR and HMGCS1, was the top predicted pathway to be deregulated ... See full document
16
C elegans ISWI and NURF301 antagonize an Rb like pathway in the determination of multiple cell fates
... Reduction of isw-1 and nurf-1 function suppressed abnormalities associated with defects in the germline-versus-soma cell-fate decision caused by lin-15B(n744) and lin-35(n745), including the ectopic somatic expression of ... See full document
10
Enhancing solubility of deoxyxylulose phosphate pathway enzymes for microbial isoprenoid production
... E. coli growth and induction of protein expression A colony was picked from agar plate, inoculated into 2xPY medium (20g/L Peptone, 10g/L Yeast extract, and 10g/L NaCl, pH=7) containing proper antibiotics, and incubated ... See full document
8
An Evolutionarily Conserved Pathway Essential for Orsay Virus Infection of Caenorhabditis elegans
... primarily C. elegans intestinal cells (5) and leads to morphological disrup- tions of the intestine ...proteasome pathway (8) have been ...a C. elegans ortholog of human Wiskott-Aldrich ... See full document
16
An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans
... in C. elegans, we used reverse transcription-quantitative PCR (RT-qPCR) to quantify the viral loads of sta-1 and sta-2 mutants following infection by the Orsay ...RNAi pathway using epistasis ... See full document
16
The “Mevalonate hypothesis”: a cholesterol-independent alternative for the etiology of atherosclerosis
... free radicals was observed in the aorta of mice [39]. A similar effect was seen after statin withdrawal from human endothelial cells in culture [39]. These data con- firm that stimulation of the mevalonate ... See full document
8
Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho GDI signalling and mitochondrial metabolism
... Ingenuity Pathway Analysis showed that certain toxicity functions are significantly enriched by the proteins differentially expressed in this comparative analysis (p < ...each pathway is indicated by the ... See full document
45
Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli
... MVA pathway flux, it is necessary to express the HMG-CoA reductase and MK at a higher level to decrease accumulation of HMG-CoA, and to eliminate the rate-limiting ...MVA pathway genes were divided into ... See full document
10
Functional Connectomics in C. elegans
... in C. elegans highlights the importance of applying accessible methodologies of avoidance assays while considering neural circuitry more broadly such as through the ...in C. elegans that is ... See full document
24
Transfer at C. elegans Synapses
... Transmitter release at graded synapses is usually not only sustained, but also activated at low presynaptic voltages. Consequently, depolarization as well as hyper- polarization of the presynaptic neuron can cause ... See full document
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