[PDF] Top 20 Tissue engineering in the rheumatic diseases

... applied tissue-specific chondrocytes, un- differentiated mesenchymal stem cells (MSCs) are of special interest as cell ...of tissue- intrinsic repair or stem cells (reviewed in ...autoimmune diseases ... See full document

... fat, and muscle cells, are under investigation as sources of cartilage progenitor cells for cartilage tissue engineering [203-206]. Studies in vitro indicate that the same growth and differentiation factors ... See full document

... synovial tissue and FLS clustering revealed that heterogeneity at the synovial tissue level is associated with a specific phenotypic characteristic of the cultured resident FLSs ...connective tissue ... See full document

... Erosion of periarticular bone is a central feature of RA and psoriatic arthritis [5,6]. Bone erosion mirrors a destructive process in joints affected by arthritis as it reflects damage triggered by chronic inflammation. ... See full document

... inflammatory rheumatic diseases and this may arise from different ...synovial tissue of patients with RA and associated them with the occurrence of persistent joint ...and tissue injury in ... See full document

... Genetically manipulated mice have been useful in identifying the role of specific cytokines in models of human disease. In most circumstances, ablation of a single cytokine is compatible with normal life [7], affording ... See full document

... irreversible joint damage [52]. Infl ammatory cytokines, especially TNF-α, IL-1β, and IL-6, are known to play an important role in the pathogenesis of RA, as the inhi bi- tion of these cytokines can ameliorate disease ... See full document

... infectious diseases are well known in Sub-Sahara ...non-communicable diseases including paediatric rheumatic diseases ...autoimmune rheumatic diseases (SARD) is 2 SARD cases per ... See full document

... autoimmune rheumatic diseases has paved the way to different therapeutic ...of rheumatic chronic inflammatory diseases with a meaningful impact on patients’ quality of ...autoimmune ... See full document

... The finding of an autoantigen does not prove its pathogenicity, i.e., cause of tissue injury. Experimental data support the notion that citrullinated peptides are arthritogenic autoantigens in RA. Thus, both ... See full document

... Abstract: Macrophages belong to the innate immune system giving us protection against pathogens. However it is known that they are also involved in rheumatic diseases. Activated macrophages have two ... See full document

... Synovial Tissue Biopsy Group in the past years regarding biopsy analysis and minimal requirements for clinical trials [21, ...in tissue handling [23 – 25], consensus is still lacking in other areas, such as ... See full document

... chronic rheumatic diseases are associated with significant disease- and treatment-related morbidity, thus impacting their health-related quality of life ...with rheumatic diseases such as the ... See full document

... of rheumatic diseases from 1980 to 2006 were screened manu- ally and by electronic searches of the Chinese National Knowl- edge Infrastructure (1980 to 2006), English Medical Current Content (1994 to 2006), ... See full document

... these diseases, appear to be characterized by failure of central tolerance ...of diseases arising in the setting of partial immuno- ...systemic rheumatic diseases, particularly SLE and RA, are ... See full document

... Patients with AIRD are prone to several infections, which may be a great challenge for the treating physician. Immunogenic PCV or PPV vaccines effectively reduce the risk of invasive infectious diseases and ... See full document

... Phagocytosis of yeast particles by peripheral blood and synovial fluid neutrophils was compared in the sera and synovial fluids from 16 osteoarthritis, 23 rheumatoid arthritis, and 12 mi[r] ... See full document

... non-communicable diseases in low-income (“less- hygienic”) settings. Diseases such as asthma have likely been overlooked in low-income settings for decades, in part because the burden of asthma has been ... See full document

... Abstract: Immunologic research has clarified many aspects of the pathogenesis of inflammatory rheumatic disorders. Biologic drugs acting on different steps of the immune response, including cytokines, B- and ... See full document

... In summary, the SHARE initiative will circulate sur- veys to centers and organisations involved in providing care for children with PRD. Such surveys will form the basis of a thorough inventory of current local practice. ... See full document