[PDF] Top 20 Towards host-directed therapies for tuberculosis

... Citation: Zumla, A., Chakaya, J., Hoelscher, M., Ntoumi, F., Rustomjee, R., Vilaplana, C., Yeboah-Manu, D., Rasolof, V., Munderi, P., Singh, N., Aklillu, E., Padayatchi, N., Macete, E., Kapata, N., Mulenga, M., Kibiki, ... See full document

... multidrug-resistant tuberculosis (MDR-TB) is extremely challenging due to the virulence of the etiologic strains of Mycobacterium tuberculosis ( ...aberrant host immune responses and the diminishing ... See full document

... into host-directed therapies ...adjunct therapies for shortening the duration of TB therapy and improving treatment outcomes for drug-susceptible TB and ... See full document

... attention towards alternative chemother- apies. Host-directed therapies (HDT) have emerged as a promising avenue for adjunctive treatment with the aim to modulate immune responses against the ... See full document

... modulating host responses to multiple bacterial infections and, hence, it is a suitable target for host-directed antibacterial therapeutics ...M. tuberculosis-infected host cells ... See full document

... Mycobacterium tuberculosis (Mtb), spread from human-to- human by respiratory ...of host defence against the bacillus has been heralded as fundamental to advancing global TB control [4], and recent years ... See full document

... of host-directed therapeutic agents for ...develop host-directed therapeutic interventions. Host-directed therapies (HDTs) aim to augment immune mechanisms against ...a ... See full document

... Eculizumab selectively targets and inhibits the terminal portion of the complement cascade. It specifically binds to the terminal Complement component 5, or C5, which acts at a late stage in the complement cascade [2, ... See full document

... lower still in worse disease. These findings suggest that an impaired ability to generate adequate NO (e.g. in L-arginine deficiency) might contribute to host inability to adequately contain TB or mitigate lung ... See full document

... M. tuberculosis is an intracellular pathogen and its survival within the host requires living ...pathogens. Host cell death not only inhibits bacterial replication by depriving the pathogen of its ... See full document

... Results: Fifty-five studies were screened for eligibility after the initial search, which yielded more than 1000 records. Of the 2540 participants in the 15 trials included in the meta-analysis, 1898 (74.7%) were male, ... See full document

... the presence of such long-standing authority is validated when the voting rights or shares held by the foreign partner is equivalent to a minimum of 10 percent of entire voting rights or share of the local enterprise. ... See full document

... attitude towards SDL and being a practitioner of SDL themselves can create learning conditions in the learning environment that will aim at enhancing students’ motivation to take ownership of their ... See full document

... oriented towards external rewards, and may not reveal the motivation of those voluntarily participating in CSOs, moreover, according to Houston (2005), may discourage it; therefore we have to look for individual ... See full document

... TB host biosignatures, and our study was done on individuals that presented with signs and symptoms, prior to the establishment of a clinical diagnosis, and at a community level health care clinic in a high-burden ... See full document

... Recent years, MSCs employed in the prevention and treatment of GVHD after allo-HSCT have generated a wealth of basic and clinical researches. MSCs can achieve immunosuppressive function through cell-to-cell contact and ... See full document

... Three classes of protein were detected: early proteins, class I, which include a protein capable of shutting off host protein synthesis; class II, proteins which are detected after 30 mi[r] ... See full document

... Thus, the results of this study establish that M protein does not inhibit host protein synthesis under the same conditions in which it potently inhibits host transcription and suggest th[r] ... See full document

... RAS proteins are the founding members of the RAS superfamily of GTPases. They are involved in key signaling pathways regulating essential cellular functions such as cell growth and differentiation. As a result, their ... See full document

... Endoscopic ultrasound (EUS) with fine needle aspira- tion (FNA) of the pancreatic head mass was performed. Sonographically, there was a 3 cm irregular mass within the head of the pancreas extending into the porta ... See full document