[PDF] Top 20 β TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin imposed restriction to HIV 1 release
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β TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin imposed restriction to HIV 1 release
... Tervo 1 , Stefanie Homann 1,2 , Ina Ambiel 1 , Joëlle V Fritz 1 , Oliver T Fackler 1* , Oliver T Keppler 1* Abstract Background: The cellular transmembrane protein ...restricts ... See full document
15
HIV 1 Vpu Blocks Recycling and Biosynthetic Transport of the Intrinsic Immunity Factor CD317/Tetherin To Overcome the Virion Release Restriction
... factor CD317 (BST-2/HM1.24/tetherin) imposes a barrier to HIV-1 release at the cell surface that can be overcome by the viral protein ...of Vpu results in a reduction of ... See full document
13
Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu
... HA-WT CD317 were re- duced, HA-K(18,21)A CD317 expression was unchanged or even slightly elevated in the presence of Vpu in all experiments ...L(22,23)A CD317 and HA-Y(6,8)A CD317 ... See full document
6
Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain
... the restriction factor tetherin. However, a deletion in human tetherin prevents antagonism by the Nef proteins of SIVcpz and SIVgor, which represent the ape pre- cursors of human immunodeficiency ... See full document
20
HIV 1 Vpu and HIV 2 Env counteract BST 2/tetherin by sequestration in a perinuclear compartment
... the ability of the HIV- 1 Vpu and HIV-2 Env to overcome tetherin ...removed tetherin from the cell surface, and that additionally Vpu, but not HIV-2 ... See full document
16
The ESCRT-0 Component HRS is Required for HIV-1 Vpu-Mediated BST-2/Tetherin Down-Regulation
... efficient release of HIV-1 ...in HIV-1 scission, but was related to the ability of the accessory viral protein Vpu to down-regulate the protein bone marrow stromal antigen ... See full document
20
Endogenous CD317/Tetherin Limits Replication of HIV-1 and Murine Leukemia Virus in Rodent Cells and Is Resistant to Antagonists from Primate Viruses
... the HIV-1-restrictive activity of rCD317 may allow a genetic modification of the virus to overcome the re- lease ...antagonists, HIV-1 Vpu, HIV-2 Rod Env, KSHV K5, or ... See full document
11
Anti tetherin activities in Vpu expressing primate lentiviruses
... their ability to counteract the BST-2/tetherin restriction of virus ...The HIV-1 Vpu protein is the prototypical anti-tetherin factor, and the observation that mature ... See full document
15
Vpu serine 52 dependent counteraction of tetherin is required for HIV 1 replication in macrophages, but not in ex vivo human lymphoid tissue
... S3. Vpu S52A is dispensable for HIV-1 release in primary blood lymphocytes (PBL) and Jurkat ...X4-tropic HIV- 1 isolates expressing eGFP via an IRES in PBL ...with ... See full document
13
Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism
... type 1 (HIV-1) Vpu protein are the degradation of the viral receptor CD4 and the enhancement of virion ...lation, Vpu has been shown to act as an adapter linking CD4 with the ... See full document
17
Suppression of Tetherin-Restricting Activity upon Human Immunodeficiency Virus Type 1 Particle Release Correlates with Localization of Vpu in the trans-Golgi Network
... (IRCM), 1 and Department of Microbiology and Immunology, Universite´ de Montre´al, 2 Montreal, Que´bec, Canada Received 27 August 2008/Accepted 11 February 2009 Vpu promotes the efficient release of ... See full document
17
Tetherin Antagonism by HIV-1 Group M Nef Proteins
... to overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group M due to the absence of sequences in human tetherin that confer sus- ... See full document
14
HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites
... of Vpu occurs inde- pendently of AP-1, AP-1 likely acts on Vpu directly, ...that CD317/ tetherin antagonism by virus assembly site exclusion is mediated a PM-resident pool ... See full document
15
The role of Vpu-mediated tetherin antagonism in HIV-1 fitness
... pandemic HIV-1 group M and closely related but less successful pathogens helps to expose viral vulnerabilities, which can be exploited as targets of new treatment or preventive ...distinguishes ... See full document
104
Vpu Mediated Counteraction of Tetherin Is a Major Determinant of HIV 1 Interferon Resistance
... allowed HIV-1 to cause the AIDS pandemic is of great impor- ...pandemic HIV-1 group M strains from nonpandemic or rare group O, N, and P viruses is the acquisition of mutations in the ... See full document
10
The formation of cysteine linked dimers of BST 2/tetherin is important for inhibition of HIV 1 virus release but not for sensitivity to Vpu
... virus release found that treat- ment of cells with up to 500 mM DTT did not reverse the inhibitory effect of BST-2 ...of vpu-deficient particles from HeLa cells will be interesting to investigate in future ... See full document
16
Serine-Threonine Ubiquitination Mediates Downregulation of BST-2/Tetherin and Relief of Restricted Virion Release by HIV-1 Vpu
... dissociated Vpu from ...of Vpu was evident in the case of wild-type BST-2 in the absence of ...constitutive, Vpu- independent ubiquitination of BST-2 likely occurs elsewhere on the ...C, S, ... See full document
13
HIV 1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
... the tetherin restriction through an as yet unknown ...that HIV-1 Groups O and N can cause AIDS [45,46], whereas the pathogenic potential of Group P remains to be ...pandemic ... See full document
9
The transmembrane domain of HIV 1 Vpu is sufficient to confer anti tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function
... pandemic HIV-1 M strains [12,50] and that easier adaptability of Vpu to humans may explain why only certain SIVcpz and SIVgor strains have become new human pathogens ...of Vpu, which may help ... See full document
14
CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection
... compare CD317 incorporation into purified cell- free wt and delVpu HIV-1, we used the C3A variant of CD317 that does not restrict the release of Vpu-defective ... See full document
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