[PDF] Top 20 Using Stem Cells to Model Diseases of the Outer Retina

... retinal cells are an ideal in vitro model for disease ...of diseases, including, RP, but also deliver a means of identifying possible therapeutic strategies ...broblast cells from fi ve RP ... See full document

... − cells when injected into mice with adriamycin-induced nephropathy glomerular, which are engrafted into the glomerular structures and tubular structures, accounted for ...tubular cells in ...− cells ... See full document

... the model of endotoxin-induced ALI in mice lead to the least infiltration of inflammatory cells, no apoptosis, and maintained lung architecture ...ARDS model in rabbit, the absence of calcification ... See full document

... vascular retina, and this knowledge will facilitate the translation of basic studies into clinical ...vascular diseases, providing a framework for their study in animal ... See full document

... the cells to self-organize and proceed along a developmental trajectory not unlike that which occurs in vivo ...to model human diseases, particularly those affecting developmental ... See full document

... colleagues using the four Yamanaka factors, which were then excised by Cre-mediated recombination in 2009 ...animal model for the fi rst time [2]. Using a scalable process for the production of ... See full document

... infarction model, SDF-1 expression was increased only in the early phase post infarct stimulating the recruitment of MSCs to injured heart as well as enhanced angiogenesis and improved cardiac function ...of ... See full document

... T cells stimulate monocytes, macrophages, and FLSs to produce inflammatory mediators, including IL-1, TNF- α , IFN- γ , and IL-6, and secrete MMPs, leading to the systemic inflammation that eventually results in ... See full document

... study using iPS cells to model a disease, Ebert and colleagues generated iPS cells from a SMA patient and used them to derive motor neurons ...control cells – suggesting that SMA motor ... See full document

... AFS cells are primary cells of a very early stage of human ...AFS cells, unlike ES and iPS cells, do not induce tumor formation in severe combined immunodeficient mice ...AFS cells, ... See full document

... Bleomycin (BLM)-induced alveolar injury is well charac- terized in mice [46,47], and has been used as a model to test therapeutic potential of hES-ATIICs [45]. When transplanted into SCID mice on day 1 or 2 after ... See full document

... into cells that show contractile ...MI model, which resulted in noticeable improvements in cardiac function and the prevention of myocardial remodeling via secretion of the proangiogenic factors VEGF, HGF, ... See full document

... of diseases, including monogenic diseases such as spinal muscular atrophy (SMA) and complex diseases such as Parkinson’s disease (Wu and Hochedlinger, ...of using iPSCs to model a ... See full document

... “magnetic” cells, and thus markedly enhanced vascular density ...of stem cells was used to increase the implanted ADSC retention in the infarcted ...ischemic diseases via increasing cell ... See full document

... measured using electric cell-substrate impedance sensing (ECIS, Applied Biophysics, NY, ...U.S.A.) using a 1600R ECIS model. Cells were plated on eight-well plates (8W10E + plates, Applied ... See full document

... photoreceptor outer segments and subsequent photoreceptor death in the macula, resulting in central vision loss (Sparrow et ...the retina, leading to wet AMD and a rapid, devastating loss of central vision ... See full document

... retinal diseases that feature degeneration of rod and cone PRs and characteristic retinal deposits ...rare model of X-linked RP) demonstrate a decrease in the intensity of ZO-1 staining ... See full document

... (GM-CSF), stem cell factor, vascular endo- thelial growth factor (VEGF), and stromal cell-derived factor-1-alpha (SDF-1-alpha) in ischemic stroke ...of stem cells to augment growth factor in AD in ... See full document

... Animal model of liver fibrosis and cirrhosis was induced by subcutaneous injection of CCl4 at a dose of ...mesenchymal stem cells (BM-MSCs) and fifty healthy male albino rats weighting 180-220g were ... See full document

... mice using immunostaining and Western blot. With immunostaining we quantify differences between young and old where these appear to be obvious. Figure 1A shows that the intensity of Fis1 labelling is significantly ... See full document