[PDF] Top 20 Variable course of primary simian immunodeficiency virus infection in lymph nodes: relation to disease progression.
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Variable course of primary simian immunodeficiency virus infection in lymph nodes: relation to disease progression.
... The persistence of productively infected cells in LN, rather than that of viral particles, was found to be associated with rapid disease pro- The central role of lymphoid organs in the p[r] ... See full document
10
Simian Immunodeficiency Virus Disease Course Is Predicted by the Extent of Virus Replication during Primary Infection
... dramatic disease-causing properties in rhesus macaques (12, 43) (although the passage history and culture conditions of SIVmac251 stocks used by different investigators may vary in ways that affect the relative ... See full document
11
Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy.
... in lymph nodes of SIVmac1A11-infected animals before week 13 ...SIVmac1A11 infection has al- ready been reported in an analysis of anti-SIV antibody pro- duction ...during primary ... See full document
10
CD4+-T-Cell and CD20+-B-Cell Changes Predict Rapid Disease Progression after Simian-Human Immunodeficiency Virus Infection in Macaques
... colonic lymph nodes was noted along with pyogranulomatous ...of virus binding antibody, level of neutralizing antibody, and plasma ...of virus- binding antibody, a low level of neutralizing ... See full document
6
Effect of Humoral Immune Responses on Controlling Viremia during Primary Infection of Rhesus Monkeys with Simian Immunodeficiency Virus
... a disease course typical of a “rapid ...of disease progression occurs in about one-fourth of all SIV- mac251 infections, it is unclear whether B-cell depletion played a role in the clinical ... See full document
9
Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase
... HIV infection was originally proposed a de- cade ago; in fact, it has been demonstrated that type I IFN in the sera of chronically HIV-infected patients was associated with disease progression, ... See full document
9
Mamu-A*01 Allele-Mediated Attenuation of Disease Progression in Simian-Human Immunodeficiency Virus Infection
... against disease progression in both human immunodeficiency virus type 1 and simian immunodeficiency virus ...in simian-human immunodeficiency virus ... See full document
10
Primary Simian Immunodeficiency Virus SIVmnd-2 Infection in Mandrills (Mandrillus sphinx)
... of infection is an excellent predictor of the subsequent disease course (33, ...to disease than those with lower viral loads (VLs), suggesting that viral replication is a major determinant of ... See full document
9
nef Gene Is Required for Robust Productive Infection by Simian Immunodeficiency Virus of T-Cell-Rich Paracortex in Lymph Nodes
... AIDS virus infection in terms of viral replication, host immune response, and disease progression has been reported from HIV type 1 (HIV-1) clin- ical studies (45) and studies of animal AIDS ... See full document
12
Macaques with Rapid Disease Progression and Simian Immunodeficiency Virus Encephalitis Have a Unique Cytokine Profile in Peripheral Lymphoid Tissues
... a variable number of cycles to identify a linear range of amplification for each ...in lymph nodes from SIV-infected animals (n ⫽ 28) compared to uninfected controls (n ⫽ 5) ...following ... See full document
5
Enhanced Replication of Simian Immunodeficiency Virus Adjacent to Catecholaminergic Varicosities in Primate Lymph Nodes
... human immunodeficiency virus type 1 (HIV-1) infection have documented accelerated clinical dis- ease onset and an elevated plasma viral load among individuals subjected to long-term stress (6, 21), ... See full document
10
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection
... to disease progression in chronic simian immunodeficiency virus/human im- munodeficiency virus (SIV/HIV) ...Mesenteric lymph nodes (MLNs), which drain the large and small ... See full document
16
Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in Simian Immunodeficiency Virus-Infected Monkeys
... SIV infection of rhesus ...to disease (REi9, RHk8, RJj8, RJl9, RKb9, RWi8, RWu8, and RZz8) and slow progres- sors (RCe8, RCo8, RDo8, RIf8, RNr8, ROu8, and ...throughout disease progression: 7 ... See full document
12
Severe Depletion of CD4+ CD25+ Regulatory T Cells from the Intestinal Lamina Propria but Not Peripheral Blood or Lymph Nodes during Acute Simian Immunodeficiency Virus Infection
... the lymph nodes and colons of SIV-infected macaques during the terminal stages of the disease ...acute infection, we used an accelerated and consistent SIV/pigtailed macaque model of HIV-1 ... See full document
10
Is the Gut the Major Source of Virus in Early Simian Immunodeficiency Virus Infection?
... of virus in the blood, the rapid death of these CD4 ⫹ T cells cannot be con- nected with the peak of virus replication during acute SIV ...to infection of different anatomical compartments affect the ... See full document
7
Glycosylation of Simian Immunodeficiency Virus Influences Immune-Tissue Targeting during Primary Infection, Leading to Immunodeficiency or Viral Control
... human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) play pivotal roles in modulating virus-target cell ...pathogenic infection of TrM-Th1 cells in ... See full document
14
Programmed death of T cells in human immunodeficiency virus infection No correlation with progression to disease
... Programmed death of T cells has been proposed as one of the mechanisms by which HIV affects immune functions in stages of infection where the number of infected cells is low. Indeed, in HIV-infected individuals ... See full document
8
TRIM5α Restriction Affects Clinical Outcome and Disease Progression in Simian Immunodeficiency Virus-Infected Rhesus Macaques
... to simian virus 40 (SV40) ...-sensitive virus SIVsmE543-3 progressed to AIDS within 2 years after infec- ...SV40 infection was also indicated in macaque ... See full document
8
Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection
... the course of primary infec- ...following infection, and the loss of CD4 ⫹ T-lymphocyte subsets, defined by the various antibody combinations, had similar associations with set point viral loads in ... See full document
7
Dynamics of Simian Immunodeficiency Virus SIVmac239 Infection in Pigtail Macaques
... SIV infection in these animals is ...lentiviral infection in ...SIV infection, and this progression is often associ- ated with thrombocytopenia (TCP) (2, ...ficiency virus ... See full document
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