[PDF] Top 20 The Viral E8^E2C Repressor Limits Productive Replication of Human Papillomavirus 16
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The Viral E8^E2C Repressor Limits Productive Replication of Human Papillomavirus 16
... Papillomavirus 16 Elke Straub, Marcel Dreer, Jasmin Fertey, Thomas Iftner, Frank Stubenrauch University Hospital Tübingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Division ... See full document
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Characterization of the Human Papillomavirus 16 E8 Promoter
... of Viral Diseases, Division of Experimental Virology, Tuebingen, Germany ABSTRACT Persistent infections with certain human papillomaviruses (HPV) such as HPV16 are a necessary risk factor for the ... See full document
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Growth Inhibition of HeLa Cells Is a Conserved Feature of High-Risk Human Papillomavirus E8^E2C Proteins and Can Also Be Achieved by an Artificial Repressor Protein
... HPV31 E8^E2C and demonstrated that it is a potent repressor of viral transcription and ...that E8^E2C proteins may differ in their ...of E8^E2C proteins of HPV16, ... See full document
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The E8∧E2 Gene Product of Human Papillomavirus Type 16 Represses Early Transcription and Replication but Is Dispensable for Viral Plasmid Persistence in Keratinocytes
... E2 repressor isoforms inhibit the full-length E2-TA by forming E2 repressor/E2-TA heterodimers capable of dis- placing the E2-TA homodimers at their cognate binding sites (reviewed in reference ...the ... See full document
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Activation of NF-κB by Human Papillomavirus 16 E1 Limits E1-Dependent Viral Replication through Degradation of E1
... that this was attributable to ATM-mediated phosphorylation of these proteins. In clones of the tetON E1⫹E2 cells, the phosphor- ylation of ATM, CHK1, and CHK2 was also increased following incubation with DOX and a ... See full document
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The E8 Domain Confers a Novel Long-Distance Transcriptional Repression Activity on the E8^E2C Protein of High-Risk Human Papillomavirus Type 31
... high-risk human papillomaviruses (HPVs) are the major risk factor for the development of anogenital ...cancers. Viral E2 proteins are involved in viral DNA replication and regulation of ...the ... See full document
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The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle
... the human papillomavirus type 16 (HPV-16) is intimately tied to the differentiation of the host epithelium that it ...DNA replication machinery to establish itself as a low-copy-number ... See full document
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The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome
... for viral production upon keratinocyte ...in viral DNA replication at different stages, an E1-defective mutant of the human papillomavirus 16 (HPV16) genome featuring a ... See full document
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The Fanconi Anemia Pathway Limits Human Papillomavirus Replication
... Taken together, these data show that FA loss stimulates the HPV replicative life cycle. DISCUSSION We demonstrate here that the FA pathway, widely known for its important role in DNA repair, controls the ... See full document
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Identification of the E9^E2C cDNA and Functional Characterization of the Gene Product Reveal a New Repressor of Transcription and Replication in Cottontail Rabbit Papillomavirus
... abortive viral life cycle characterized by low levels of viral DNA amplification and the lack of virus ...production. Viral copy numbers are much lower in domestic rabbit papillomas than in ... See full document
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Viral trans factor independent replication of human papillomavirus genomes
... amplification replication occurs immediately after infec- tion and the viral DNA is stably maintained in the undif- ferentiated basal ...amplification replication, which increases the HPV DNA copy ... See full document
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Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle.
... of human papillomavirus type 16 (HPV-16) replication has been impaired because of the lack of a cell culture system that stably maintains viral ...DNA replication in these ... See full document
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Productive Replication of Human Papillomavirus 31 Requires DNA Repair Factor Nbs1
... for productive viral replication but not epi- somal ...of viral replication upon differentiation, suggesting that productive replication may occur through a mechanism ... See full document
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An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome Establishment
... onstrate that E2 TopBP1 activates transcription. The pattern of acti- vation is distinct from E2 WT with no squelching at higher levels, and there is a significant difference between E2 TopBP1 and E2 WT activity at 10 ng ... See full document
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Productive Replication of Adeno-Associated Virus Can Occur in Human Papillomavirus Type 16 (HPV-16) Episome-Containing Keratinocytes and Is Augmented by the HPV-16 E2 Protein
... DNA replication, in line with the idea that a mitotic block may be sufficient to provide some help for ...by viral proteins—implicating cell cycle control ...DNA replication, we found that it was ... See full document
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Effect of Productive Human Papillomavirus 16 Infection on Global Gene Expression in Cervical Epithelium
... early productive stages of HPV infection, whereas the other studies focused on the cancerous stages of infection, when viral production is significantly ...efficient viral replication and ... See full document
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Effect of Productive Human Papillomavirus 16 Infection on Global Gene Expression in Cervical Epithelium
... early productive stages of HPV infection, whereas the other studies focused on the cancerous stages of infection, when viral production is significantly ...efficient viral replication and ... See full document
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Homologous Recombination Repair Factors Rad51 and BRCA1 Are Necessary for Productive Replication of Human Papillomavirus 31
... High-risk human papillomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage response (DDR), which is necessary for productive viral ...per ... See full document
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Mapping of Betapapillomavirus Human Papillomavirus 5 Transcription and Characterization of Viral-Genome Replication Function
... which E8 ORF-containing pro- teins are translated. We demonstrated that the E8^E2C fusion protein acts as an important negative regulatory factor for gene expression, leading to the suppression and ... See full document
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Variant Upstream Regulatory Region Sequences Differentially Regulate Human Papillomavirus Type 16 DNA Replication throughout the Viral Life Cycle
... DNA replication, and ...of viral genes is expressed to ensure stable viral plas- mid replication in dividing cells without generating progeny virions ...The productive stage of ... See full document
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