M C O
1) Adverse effects of aminaglycosides include the following except a) Nephrotoxicity and ototoxicity
b) Neuromuscular blockade .
c ) P s e u d o m e m b r a n o u s c o l i t i s . d) hypersensitivity reactions .
2) Concerning vancomycin , the following are correct except ; a) lt inhibits synthesis of bacterial cellwall
b) lt is used intravenously as seconds chojce drug in pseucomembranous colitis c) lt is effective as first choice drug against ORSA ( MRSA)
d) Histamine release is one of its adverse effects
3) Antimicrobials contraindicated in infants and childr€n include a) Tetracycline
b) Clindamycin c) Clinafloxacin d) Chloramphenjcol
4) The following antitubercular drug can cause gouty arthritis :
the following except
a) Ethambutol b) Pyrazinamide c) Streptomycin d ) t N H
5) The antimicrobial thatcould be safely given orally in lats pregnancy with gram negative infections is :
a) Tetracycline b) Ceftriaxone c) Cefaclor
d) Cotrimoxasole
6) Th€ elimination half life of which of the following drugs remains unchanged when it is administered to patients suffering from impaired renal function i
a) CefoDerazone. b) Azithromycin. c) Doxycycline. d) All of the above .
7) The elimination half life of which of the following drugs remains unchanged when is administered to patients suffering from impaired renal function :
a) Tetracycline b) Erythromycin. c) Doxycycline d) All of the above
8) A cephalosporin with increased activity against anaerobic bacteria is ; a) Cephalexin
b) Cefuroxime c) Cefoxitin d) Cefazolin
9) A characteristic adverse effect associated with the use of ampicillin is : a) phototoxicity
b) l\4aculopapularrash c) Acute haemolytic anemia d) Agranulocytosis
10) Adverse effects of Rifampicin include all ofthe following except: a) Flu like effects.
b) Red discolouration of secretions
c) Increased plasma level of concomitanfly used drugs
d) lt is required to increase dose of concomitanflv used druos.
12) The following drugs may interfere with plasma level of othlr drugs except: a) Ciprofloxacin.
b) Chloramphenicol. c) Rifamoicin.
d ) A m o i c i l l i n .
13) The following antibiotics inhibit bacterial ce wall synthesis except: a) Cephalosporins
b) penicillins c) Erythromycin d) Vancomycin
14) All the following antimicrobials are correcfly matched to their uses oxcept: a) Rifampicin - prophylaxis of meningitis
b) metronidazole - anaerobic infections c) Amoxicillin - typhoid fever
d) Cephalexin - treatment of meningitis
15) All the following antitubercular drugs can affect other drug's l6vel exc€pt : a) Rifamoicin
b ) I N H
c) Streptomycin d) l\y'oxifloxacin
16) All the following antitubercular drugs are not hepatotoxic except: a) Ethambutol
b) Pyrazinamide c) Ceftriaxone d) Capreomycin
'17) All the following are adverse effects of vancomycin except: a) Pseudomembranous colitis
b) Ototoxicity c) Nephrotoxicty d) Red-man syndrome
'18) All the following are contraindicated in renal dysfunction except a) Doxycycline
b) Tetracycline c) Gentamycin d) Amohotericin B
19) All the following are true about cotrimoxazole except:
a) lt is the treatment of choice for pneumonia due to pneumocystis carinii b) lt is an alternative to chloramphenicol for enteric fever
c) lt is replaced by trimethoprim alone for urinary tract infections due to E.coli d) lt is a combination of trimethoprim and clavulanic acid
20) All the following are used against penicillinase producing Staphylococci except: a) Cloxacillin.
b) Clindamycin. c) Co-trimoxazole. d) Amoxicillin.
21) All the following_concerning antitubercular drugs are correct except: a) lsoniazide, Rifampicjn and cycloserine are first_line druos
b) Hepatrc damage can occur with isoniazjde and Rifampiiin c) Ethambutol induces optic neuritis
d) Pyrazinamide rnduces hyperuricemia
22) The following increase the risk of nephrotoxicityof gentamycin except : a) Age over 70 years .
b) Prolonged course of therapy . c) Concurrent vancomycin therapy d) Concurrent therapy with penicilljn 23) All the following statements correcfly
chemotherapeutic agent except :
identify the mechanism a) Aminoglycosides - irreversibly bind to 3OS ribosome
b) Tetracycline - reversibly binds to SOS ribosome c) Chloramphenicol - irreversibly binds to 50S ribosome d) Macrolides - reversibly bind to S0S ribosome.
24) Amikacin has the following advantage over gentamycin. a) Better oral absorption.
b) Less nephrotoxic
c) Less susceptible to bacterial inactivation. d) Less allergenic.
25) Aminoglycosides have the following characters except: a) They are inetfective against anaerobic organisms b) They act by inhibiting protein synthesis.
c) They can be absorbed well after oral intake . d) They are ineffective in treatment of menincitis. 26) Aminogtycosides inhibit bacterial protein sy;thesis by :
a) Binding to 30S rlbosome leading to inhibiton of bindinq to tRNA b I Binding to 30S nooso.ne reading to mrsreading of mRNA code c) Binding to 50S r bosome preventing transJocation of peptide charn d) Binding to 50S ribosome leadrng to inhrbition of transpeptidatiorl
27) A narrow spectrum oral drug, effective against +ve gm anerobic bacteria is; a) Vancomvcin
b) Aztreonam c) Tobramycin d ) C l i n d a m v c i n
28) Antibiotic - associated pseudomembranous colitis is mostl i k e l y t o b e c a u s e d b y : a) Vancomycin
b ) A Z i t h r o m y c i n . c) Clindamycjn. d) l\iletronidazole.
29) Antimicrobials effective in anaerobic infections include all
a) Chloramphenicol the following except:
b) Gentamycin c) Clindamycin d) L4etronidazole
30) A patient with hypersensitivity to penicillin V acquired an infection with
streptococcus pneumonia, which of the following antimicrobiats w6uld be the best choice for that patient:
a) Amoxvcillin / clavulanate.
b) Cefaclor.
c) Erythromycin.
d) Ampicillin.3'l) A bacteriostatic antibiotic that becomes bactericidal at highfoncentration is : a) Tetracycline.
b) Erythromycin. c) Vancomycin. d) AmDicillin.
32) Arrange the following beta lactam antibiotics according to their spectrum of action ( the most narrow soectrum first ) :
a) lmipenem b) Aztreonam c) Amoxycillin a ) a , o , c
b ) a , c , b c ) b . a . c d ) b , c , a e ) c , a , D
33) Arthralgia may be an adv€rsg effect of: a) capreomycin
b) pyrazinamide c) rifampicin d) ethambutal
34) Augmentin is a combination of
a) broad spectrum penicillin and antistaph penicillin b) broad spectrum penicillin and B-lactamase inhibitor c) antipseudomonal penicillin and antistaph penicillin d) none of the above
35) A 6l year old woman who is allergic to penicillin and cefoxetin has a staphylococcal septicemia with organisms resistani to tetracycline and erythromycin . The most appropriate for treatment of this patient is:
a ) C a r b e n i c i l l i n b) Cefaclor c) Amoxicillin d) Vancomycin
36) Clindamycin has the following except: a) associated with diarrhea
b) active against anaerobes
c) active against some gram-positive organisms d) active against most gfam-negative organisms
37) Concerning aminoglycosides, the following are true except: a) They are mainly effective in anaerobic gram negative bacteria
b) They cause concentration - dependent not time -dependent bacterial killing c) Their doses should be adjusted according to creatinine clearance
d) They have synergistic antimicrobial effects with B-lactams 38) Concerning aminoglycosides, the following are true except:
a) They are mainly effective in aerobic gram negative bacteria.
b) They cause time - dependent not concentration - dependent bacterial killing. c) Their doses should be adjusted according to creatinine clearance.
d) They have synergistic antimicrobial effects with B-lactams. 39) Concerning fluroquinolones, the following are true except;
b) Cloxacillin c) Piperacillin d) Nafcillin
50) lsoniazide is a primary antituberular agent that: a) Requires pyridoxine supplementation . b) May discolor tears. Saliva, feces and urine c) lvlay be otoboxic
d) ls given only intramuscularly
51) Macrolides inhibit bacterial protein synthesis by :
a) Binding to 30S ribosome leading to inhibition of binding to IRNA. b) Binding to 30S ribosome leading to misreading of mRNA code. c) Binding to 50S ribosome preventing translocation of peptide chain. d) Binding to 50S ribosome leading to inhibition of transpeptidation. 52) One of the following about ceftriaxone is correct :
a) lt is bactericidal .
b) It acts by inhibiting protein synthesis. c) lt is effective orally and parentrally. d) Hepatic toxicity is a main side effect.
53) Ototoxicity can follow the administration of the following except : a) Ethacrynic acid.
b) Gentamycin. c) Frusemide. d) Cefuroxime.
54) Pick out tho betalactamase inhibitor for co.administration with penicillins: a) Ethacrynic acid
b) Sulbactam. c) l\,4onobactam. d) Moxalactam.
55) Pneumococcal meningitis in a'14 year old patient is treated with : a) Erythromycin.
b) Rifamoicin. c) Cettriaxone. d) Ciprofloxacin.
56) Pseudomembranous colitis may be treated with ; a ) C l i n d a m y c i n
b) Vancomycin c) Metronidazole d ) b a n d c
57) Regarding isonizide ( INH) , the following are true €xcept: a) lt inhibits the synthesis of mycolic acid in mycobacterial cell wa b) lt produces hepatic toxicity in rapid acetylators.
c) lt causes stimulation of hepatic microsomal enzymes. d) lts neurotoxicity can be prevented by pyridoxine. 58) The antibiotic of choice in hepatic coma is:
a) Cephalexin.
b) ChloramDhenicol. c) Neomycin.
d) Penicillin G.
59) The antimicrobial drug that is safely given in renal impairment is a) Gentamvcin.
b) Vancomycin. c) Doxycycline d) Tetracycline.
60)The aminoglycoside most likely to remain gentamicin-resistance is :
a) Streptomycin. b) Amikacin. c) Neomycin. d) Kanamycin.
a useful therapeutic agent in the event of
61) One of ths following drugs is effective against anaerobic bacteria: a) Ceftriaxone
b) Flucloxaillin
c) Benzathine oenicillin e) l\4etronidazole
62) The best ag€nt of the following drugs effective against meningocdcci is: a) Ceftriaxone
b) Flucloxacillin c) Doxycycline
d) Benzathinepenicillin
63) The best agent of the following drugs effective against mycoplasma is: a) Ceftriaxone
b) Doxycycline
c) Benzathine penicillin d) Metronidazole
64) The best agent of the following drugs effective against Staph aureus isi a) l\y'etronjdazole
b) Flucloxacillin c) Doxycycline
d) Benzathine penicillin
65) The.b^est agent of following drugs effective prophylactic in Strept. hemolyficus is: a) Ceftriaxone.
b) Flucloxacillin. c) Doxycycline.
d) Benzathine penicillin.
66) The drug of choice for methicillin- resistant Staphylococcus aureus is: a) Oxacillin.
b) Gentamycin. c) Vancomycin. d ) P i D e r a c i l l i n . e) None of the above.
67) The drug ot choice in a patient with allergy to penicillin is : a) lmioenem
b) Cefradin c) Aztreonam. d) Erythromycin.
68) The following drug is effective in treatment of anaerobic infection : a) Streptomycin.
b) Gentamyctn. c) Clindamycin. d) Ciprofloxacin.
69) The following drugs are better avoided with oral a) Co-trimoxazole. b) Erythromycin. c) AmDicillin. e x c e p t : d) Chloramphenicol.
70) The following drugs are contraindicated in infants and children except: a) Tetracyclines.
b) Co-trimoxazole. c) Cefradin.
d) Ciorofloxacin.
71) All of the following drugs can be used in anasrobic infection except: a) Tindiazole.
b) Clindamycin. c) Gentamycin. d) Cefoxitin.
72) All of the following are true regarding Rifampicin except: a) Inhibits DNA dependent RNA polymerase enzyme. b) Induces fluid discoloratior,.
c) Increase plasma level of theophylline. d) Etfective in treatment ofTB.
73) All of the following are true regarding quinolones except: a) lnhibit DNA gyrase enzyme.
b) Clinafloxacin is 4'n generation and used in anerobic jnfection. c) Ciproflaxacin is more effective than levofloxacin in pneuomonia. d) Norfloxacin is used in UTI only as it does not achieve systemic level. 74) Which of the following used in prophylaxsis of meningitis:
a) Ciprofloxacin. b) Gentamycln. c) RifamDicin. d) lsoniazide.
75) Typhoid fever in 12 years old patient has favism is treated byi a) Co trimoxazole.
b) Ciorofloxacin. c) Amoxacjllin.
d) Chloramohenicol.
76.Which of the following is considered the 1"! in patient allergic to penicillin a l m t p e n e m .
b. Cefazolin. c. Erythromycin. d. Aztreonam.
77.Chose the best drug for a patient with history of allergyto penicillinand suffering from severe infection by -ve bacilli.
a. Ampicillin and sulbactam. b. Aztreonam.
. c . lmrpenem, d. Cefazolin.
78.The penicillin G with the longesl duration of action is: a. Procaine penicillin.
b. Benzathine penicillin. c. Penicillin V.
d. Benzyl penicillin.
79.The main reason for limited use of Chloramphenicol a. Nephrotoxicity.
b. Aplastic anemia. c. Hepatic toxicity. d. Ototoxicity.
80.Which of the following is not a semisyntheticp e n i c i l l i n : a. Procaine penicillin.
b . A m p i c i l t i n . c. Cloxacillin. d. Carbenicillin.
8l.Which of the following drug may induce a. Erythromycin.
b. Streptomycin. c. Vancomycin. d. Clarithromycin.
is the highiincidence of:
flushing
and redness
after
raDid
lvl:
commonly with: S2.Antibiotic associated pseudomembranous colitis occurs
a. Amoxacillin. b. Metronidazole. c . C l i n d a m y c i n . d. Vancomycin.
83.Which of the following drug is most suitable for anaerobic dentat infection: a. Gentarnycin.
b. Erythromycin c . C l i n d a m y c i n d. Aztreonam.
84.All of the following drugs effective in anaerobic infections exceDt: a. Cefoxitine
b . C h l o r a m p h e n i c o l c . G e n t a m V c t n . d l\4etronidazole.
85. Which_of the following drug can cross BBB and effective in meningitis. a . G e n t a m y c l n .
b. Cefoperazone. c. Ceftrioxone. d . D o x y c l c l j n e .
86.Which of the following is side effect of quinolones. a. Otoioxicity.
b. Pseudomembranous coiitis. c. Arthropathy.
d. Teeth discoloration.
87. All following adverse effects are matched with corresponding drug except: a. Cefoperazone / Disulfiram like action.
b. Vancomycin/ Red man syndrome.
c. Outdated tetracyclines / fanconi syndrome. d. Sulfonamides / Grey baby syndrome.
88. All following indications are matched with the corresponding drug excepr: a. Prophylactic in rheumatic fever / Benzathine Denicillin.
b. Cefoxitin: l\,4ixed anerobic infections. c. Vancomycin / Typhoid fever.
d. Metronidazole / Psedomembranous colitis.
89.All following adverse effects are matched with corresponding drug except: a. Rifampicin / Flu like syndrome.
b. INH / nephrotxicity. c. Ethamutol / Optic neuritis. d. Pyrazinamide / gouty arthritis.
90. Macrolides: all of the following are true except a. Bactericidal in large doses.
b. Eyrhromycin is one of them and jnduces cholestatic jaundice. c. Spectinomycin is one of them and used in resistant;onorrhea. d. Inhibit translocatton reaction of bacterial ribosome.
91. Which of the following is not effective in typhoid fever: a . P e n i c i l l i n V .
b. Amoxacillin. c. Ampicillin. d. Co trimoxazole.
92. Which of the following is not effective in BTt: a. Doxycline.
b. Ceftrioxone. c. Rifampicin. d. centamycin.
93. Which of the following is not effective in pseudomonas infections: a. Cefoperazone.
b . l m i p e n e m . c. Penicillin G. d. Gentamycin.
94.Which ofthe following is not used in gonorrhea: a . P e n i c i l l i n c
b. Spectinomycin. c. Norfloxacrn. d. Vancomycin.
95. Which of the following is used safely in pregnancy: Gentamycin.
Erythromycin. Doxycycline. l\4oxifloxacin.
following pairs are true except: Clinafloxacin / inhjbits DNA gyraze INH / Inhibits mycolic acid synthesis.
Cefrazolin / inhibits transpeptidase enzyme. Rifampjcin / inhibits RNA d dent DNA a . b . c . d . 96. All of the a . b . c d . l c l I n n r D r t s K N A 0 e 0 e n ovtmera:e 2 = b 6 = d 9 = b '10=c 12=d 14=d 1 6 = b 1 8 = a 1 9 = d 20=d 2 2 = d
