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Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles

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Figure 1 size distribution by the intensity of micelles prepared by (A) mPeg2000–PDlla2000 with a particle size of 22 nm, (B) mPeg2000–PDlla5000 with a particle size of 48 nm, (C) mPeg2000–PDlla8000 with a particle size of 124 nm
Figure 2 The biodistribution of Dir/coumarin 6-loaded mPeg2000–PDlla5000 micelle (48 nm) in tumor tissue in a 4T1 tumor-bearing mice.Notes: (A) MSOT image of a 4T1 tumor-bearing mice with 48-nm micelle postinjection at 3.5, 5, 7, and 9 hours (a–d)
Figure 3 Optoacoustic analysis of the intratumoral distribution of polymeric micelles after intravenous injection.Notes: MsOT imaging results of (A) 22-nm micelle: central parts at 0.1 hour (a) and 5 hours (b), border parts at 0.1 hour (c) and 5 hours (d); (B) 48-nm micelle: central parts at 0.1 hour (a) and 5 hours (b), border parts at 0.1 hour (c) and 5 hours (d); (C) 22-nm micelle: central parts at 0.1 hour (a) and 5 hours (b), border parts at 0.1 hour (c) and 5 hours (d); (D) mean intensity obtained by MsOT imaging of 22-, 48-, and 124-nm micelles; and (E) central-to-border intensity ratio of 22-, 48-, and 124-nm micelles.Abbreviation: MsOT, multispectral optoacoustic tomography.
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