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Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models

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Academic year: 2020

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Figure

Table I Overview of the Internal Dataset (Int.1) and the External Datasets (Ext.1–5) Used for Model Building and External Model Evaluation
Table II Parameter Estimates from the Model Fit, Number of Model Parameters and Parameter Estimates from the Bootstrap Procedure for the Systematic Covariate Model (A) and for the Fixed Allometric Model (B) Obtained with the Internal Dataset
Fig. 2 Individual predicted concentrations versus observed concentrations including a loess curve of morphine and its metabolites in the internal dataset Predictions by the systematic covariate model are depicted in panel A, and predictions by the fixed al
Fig. 3 Population predicted concentrations versus observed concentrations including loess curves of morphine and its metabolites for the systematic covariate model (A) and fixed allometric model (B)
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