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Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial

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Figure

Figure 2. Cellular uptake of AGuIX® in B16F10 cells. (a-c) Fluorescence image of B16F10 cells obtained by confocal microscopy 1 hour after the addition of 0.6 g/L AGuIX® conjugated to FITC (a)
Figure 3. Radiation exposure of B16F10 cells. (a) Surviving fraction of B16F10 after radiation exposure without nanoparticles (blue) and with incubation with 0.6 g/L
Figure 4. Brain tumor distribution of AGuIX®. (a) Mouse brains 5 and 10 days after B16F10 implantation and (b) the corresponding H&S section
Table 2. Main survival data. Main survival data of mice bearing B16F10 brain metastases following radiation exposure with or without pre-injection of AGuIX®

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