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NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals

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Figure

Figure 1: A cluster of genes revealed by microarray analysis is associated with tissue polarity in HMT3522 cell lines
Figure 3: The NFkB pathway is activated in disorganized T4-2 cells compared to polarized S1 and reverted T4 cells
Figure 4: Inhibition of the NFkB pathway reverses the malignant phenotypes of T4-2 cells in 3D culture
Figure 5: Expression of disorganization genes and activation of the NF-κB pathway are associated with aggressive 3D phenotypes of multiple breast cancer cell lines
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