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MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells
... To identify miRNAs whose expression levels were altered in pancreatic cells in response to gemcitabine treatment, we used CCK8 assay to test the effective concentrations of gemcitabine treatment in Bxpc-3 and Panc-1 ...
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Dual-strand tumor-suppressor microRNA-145 miR-145-5p and miR-145-3p ) coordinately targeted MTDH in lung squamous cell carcinoma
... miR- 145-5p (the guide strand of pre-miR-145) and miR-145-3p (the passenger strand of pre-miR-145) were significantly reduced in cancer tissues, suggesting that these miRNAs functioned as ...
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Original Article MicroRNA-145 induces cell cycle arrest in G1 phase by directly targeting KLF5 in colon cancer
... of colon cancer cells in tumor-bearing nude mice [29]. However, the mechanism of tumor inhibition by miR-145 has not been properly elucidated, and whether miR-145 may induce cell cycle arrest in colon ...
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Original Article miR-145 inhibits tumor proliferation and invasion and induces apoptosis in gastric cancer by targeting c-Myc
... eded in 6-well plate for the following experi- ment. Cells were cultured with transfection re- agent medium. miR-145 mimics and miR-145 NC were transfected using Lipo-2000 transfec- tion kit. The samples ...
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P< 0.05). Also, the group D had lower cell proportion and cell apoptosis rate than the
... Tonelli et al. announced that OA affected a greater population of females than males and clinically females suffered stronger pain inten- sity and greater functional defects [19]. And it was reported that miR-145 ...
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Regulatory Mechanism of MicroRNA 145 in the Pathogenesis of Acute Aortic Dissection
... Sixty samples of the ascending aorta in patients with AAD (28 type) and aortic valve disease (32 aortic valve replacement) were obtained during surgery. Aortic samples from donors for heart transplants were used as ...
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Evidence that diffusion limitation determines oxygen uptake kinetics during exercise in humans
... Effects of increased COHb on Vo2, VCO2, and gas exchange ratio R during moderate 145 W and heavy 260 W work intensity exercise without added carbon monoxide and with 20% COHb in one subj[r] ...
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MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells
... Results: The expression level of miR‑145 was significantly lower and the expression levels of Ang‑2 mRNA and pro‑ tein was significantly higher in the more aggressive pancreatic cancer cells (MiaPaCa‑2 and Panc‑1) ...
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Up-regulated miR-145 Expression Inhibits Porcine Preadipocytes Differentiation by Targeting IRS1
... Emerging researches revealed that miR-145 was involved in several key cellular functions, including cancer cells proliferation [8, 9], human embryonic stem cells differentiation [10, 11], and smooth muscle fate ...
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Original Article Involvement of miR-145 in the pathogenesis of osteoarthritis by mediating the expression of osteoprotegerin
... Abstract: Objective: To investigate the role of miR-145 in the pathogenesis of osteoarthritis by mediating the expres- sion of osteoprotegerin. Method: Articular cartilage tissues of 43 patients with ...
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Original Article miR-145 suppressed human retinoblastoma cell proliferation and invasion by targeting ADAM19
... Abstract: MicroRNAs (miRNAs) play critical roles in retinoblastoma (RB) initiation and progression, aberrant expres- sion of miR-145 had been frequently reported in cancer studies. However, the role and mechanism ...
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MicroRNA-145-5p inhibits gastric cancer invasiveness through targeting N-cadherin and ZEB2 to suppress epithelial–mesenchymal transition
... Abstract: MicroRNA (miR)-145-5p has been reported to function as a suppressor of cancer and plays an important role in cancer invasiveness. Epithelial–mesenchymal transition (EMT) is an important process in cancer ...
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<p>MiR-145 Regulates the Chemoresistance of Hepatic Carcinoma Cells Against 5-Fluorouracil by Targeting Toll-Like Receptor 4</p>
... node metastasis. In addition, follow-up for prognosis revealed that low miR-145 expression was linked to the unfavorable prognosis of the patients. Consistently, miR- 145 has been reported to be lowly ...
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Wāhine hauora: linking local hospital and national health information datasets to explore maternal risk factors and obstetric outcomes of New Zealand Māori and non Māori women in relation to infant respiratory admissions and timely immunisations
... Filoche et al BMC Pregnancy and Childbirth 2013, 13 145 http //www biomedcentral com/1471 2393/13/145 STUDY PROTOCOL Open Access W?hine hauora linking local hospital and national health information da[.] ...
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A fork head related multigene family is transcribed in Xenopus laevis embryos
... In1 J De" mol ~o 2~5 253 (1996) 145 A fork head related multigene family is transcribed In Xenopus laevis embryos JUTTA LEF, PETRA DEGE, MICHAELA SCHEUCHER, VERA FORSBACH BIRK, JOACHIM H CLEMENT and W[.] ...
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Diagnoza partycypacji w kulturze w województwie podlaskim
... N=550, w wieku ...ane w rozdziale pierwszym, występuje w stolicy regionu – ...dysproporcje w dostępie do kultury pomiędzy mieszkańcami Białegostoku i regionu są ...obiektywne. W celu ...
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microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer
... Distinct genetic alterations including reduced expression of miR-145 in pten-deficient PDAs versus AMEs revealed through mRNA and miR profiling, copy number variation, and mutational analysis. To molecularly ...
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Advanced age, altered level of consciousness and a new diagnosis of diabetes are independently associated with hypernatreamia in hyperglycaemic crisis
... Methods: This was a retrospective review of data for hyperglycaemic crisis admissions in Nelson Mandela Academic Hospital, Mthatha, South Africa. The prevalence of hypernatreamia (uncorrected Serum Sodium at presentation ...
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Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
... This study was undertaken to further investigate the mechanisms of resistance to Docetaxel. A number of Docetaxel resistant sub-lines were generated in the androgen-independent (PC-3, DU-145) and sensitive (22RV1) ...
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SRC RR 145 pdf
... specialization specification IntSetSSpec f state field elements; // A mathematical set of integers state field cache; // Also a mathematical set of integers invariant cache ⊆ elements //[r] ...
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