1p/19q co deletion
MGMT promoter methylation and 1p/19q co deletion of surgically resected pulmonary carcinoid and large cell neuroendocrine carcinoma
... [32]. 1p/19q co-deletion was found in three patients, who survived after 58, 50, and 30 months of follow-up comprising of 32 SCLC resected specimens, thereby indicating a good prognostic ...
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Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.
... and 1p/19q ...mutated, 1p/19q co-deletion, TERT promoter mutated); TERT-IDH (IDH mutated, TERT promoter mutated, 1p/19q-wild-type); IDH-only (IDH mutated, ...
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Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion
... characteristic 1p/19q co-deletion of important prognostic relevance, but little is known about the pathology of this chromosomal ...the 1p/19q ...the 1p/19q region ...
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Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at 1p and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component
... (mutation), 1p/19q co-deletion, EGFR and PI3K pathway variations, and p53 or Rb pathway mutation ...of 1p [10]. Up to 6 significantly recurrent regions of focal deletion have ...
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<p>The impact of adjuvant radiotherapy on molecular prognostic markers in gliomas</p>
... MLPA and MS-MLPA assays were carried out by PCR according to the manufacturer’s protocol using 50 ng of normal and tumor DNA. Reference samples were included in each experiment. The PCR, DNA denaturation, and liga- tion ...
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ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R
... Gliomas are the most common primary intracranial tumor, representing 81% of malignant brain tumors [1]. According to 2007 World Health Organization (WHO) classification criteria, gliomas can be divided into four grades ...
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Original Article Surgically treated incidentally discovered low-grade gliomas are mostly IDH mutated and 1p19q co-deleted with favorable prognosis
... chromosome 1p/19q codeletion remains ...and 1p/19q codeletion) in the development of gliomas is consistent with the model proposed by Arita H et al ...1p19q co-deletion and the ...
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Original Article Clinical significance of chromosome 1p/19q loss of heterozygosity and Sox17 expression in oligodendrogliomas
... locus-specific 1p or 19q probe and a Spectrum Green-labeled Figure ...chromosome 1p/19q in oligodendrogliomas. A: 1p deletion with two green (1q) and one red (1p) signal ...
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1p/19q codeletion and <em>RET</em> rearrangements in small-cell lung cancer
... to 1p/19q codeletion in anaplastic oligodendroglial ...identify 1p/19q codeletion and RET rearrangement in SCLC patients, 32 SCLC resected specimens were retrospectively collected between 2008 ...
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<p>Comprehensive analysis of genes based on chr1p/19q co-deletion reveals a robust 4-gene prognostic signature for lower grade glioma</p>
... chr1p/19q co-deletion leading to prolonged survival in patients with lower grade glioma from the bioinformatics ...chr1p/19q co-deletion to a certain ...in 1p/19q ...
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Original Article Glioneuronal tumor with neuropil-like islands: a histological, immunohistochemical, and molecular study of three cases
... had 1p deletion, 19q deletion and EGFR ...cases. 1p/19q intact astrocytomas and oligoastrocy- tomas showed a high incidence of IDH1 ...
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Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI
... assess 1p/19q codeletion, but it may occasion- ally result in false-positives in tumors with segmental deletions of 1p and 19q rather than the whole arm ...of 1p/19q codeletion ...
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Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities
... for deletion of both the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) for an inte- grated ...diagnosis. 1p/19q-codeletion results from a recip- rocal ...
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Whole Tumor Histogram and Texture Analyses of DTI for Evaluation of IDH1 Mutation and 1p/19q Codeletion Status in World Health Organization Grade II Gliomas
... the 1p/19q-codeletion status in the IDH1- mutant subgroup (On-line Table ...the 1p/19q-codeletion status on the basis of the LASSO procedure (Table ...The 1p/19q- codeletion ...
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Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas.pdf
... Patients who had lower-grade gliomas with wild- type IDH were older than those who had lower- grade gliomas with mutated IDH and were more likely to have a family history of cancer (Table 1, and Table S2 in Supplementary ...
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Multimodal MR Imaging (Diffusion, Perfusion, and Spectroscopy): Is It Possible to Distinguish Oligodendroglial Tumor Grade and 1p/19q Codeletion in the Pretherapeutic Diagnosis?
... We performed univariate statistical analyses using JMP9 software (SAS Institute, Cary, North Carolina). Differences in ADC be- tween tumor grades (grade II vs grade III) and tumor genotypes (1p/19q ...
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Prediction of IDH1 Mutation and 1p/19q Codeletion Status Using Preoperative MR Imaging Phenotypes in Lower Grade Gliomas
... BACKGROUND AND PURPOSE: WHO grade II gliomas are divided into three classes: isocitrate dehydrogenase (IDH)-wildtype, IDH-mutant and no 1p/19q codeletion, and IDH-mutant and 1p/19q-codeleted. ...
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Deep Learning Convolutional Neural Networks Accurately Classify Genetic Mutations in Gliomas
... A total of 5259 axial slices of tumor from 259 patients with gliomas (135 men/122 women/2 unknown; mean age, 53.2 years; mean survival, 18.8 years) were included for analysis. The distribution of gliomas included the ...
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1p spaces
... California State University, San Bernardino California State University, San Bernardino CSUSB ScholarWorks.. CSUSB ScholarWorks.[r] ...
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Volume 61: Graph Computation Models 2012
... model co-evolution where not only a single graph should be manipulated but also related ...The co-transformation of type graphs together with their instance graphs has shown to be a promising approach to ...
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