2-a] pyrimidin-4-one)
![2 Trifluoromethyl 10H benzo[4,5]imidazo[1,2 a]pyrimidin 4 one](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
2 Trifluoromethyl 10H benzo[4,5]imidazo[1,2 a]pyrimidin 4 one
... In the molecular structure of the title compound (Fig. 1), the bond lengths and angles are generally within normal ranges (Allen et al., 1987). The three fused rings of the benzo[4,5]imidazo[1,2-a]pyrimidine unit are ...
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3 (4 Methylphenyl) 2 (1 pyridyl) 3H benzo[4,5]furo[3,2 d]pyrimidin 4 one
... After filtration, the solvent was removed to give the carbodiimide 3- p-tolyliminomethyleneaminobenzofuran-2-carboxylic acid ethyl ester, (II), which was used directly without further purification. To a solution ...
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3 n Butyl 2 methoxy 1 benzothieno[3,2 d]pyrimidin 4(3H) one
... Compound (I) has two unique molecules in the asymmetric unit of the monoclinic unit cell. Molecule 1 is numbered with atoms C1–C15, S1, O1, O2, N1 and N2, while molecule 2 has atoms C16–C30, S2, O3, O4, N3 and N4. ...
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2 Morpholino 3 p tolylbenzo[4,5]thieno[3,2 d]pyrimidin 4(3H) one
... thiophene-2-carboxylic acid ethyl ester, (II), which was used directly without further purification. To a solution of (II) (15 ml) in dichloromethane (15 ml) was added morpholine (3 mmol). After the reaction ...
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1 (4 Chlorobenzoylmethyl)pyrimidin 2(1H) one
... We have previously described the crystal structures of a series of N-phenacyl-2-pyridones (Albov et al., 2004a,b, 2005). We report here the synthesis and crystal structure of their aza- analog, (2). In ...
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3,5,6 Trimethylthieno[2,3 d]pyrimidin 4(3H) one
... To a suspension of 5,6-trimethylthieno(2,3 - d)pyrimidin-4-one (181 mg, 0.1 mmol) in 50 ml e thanol sodium hydride (24 mg, 1 mmol) was added. The mixture was stirred at room temperature for 30 min. ...
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2 Diisopropylamino 3 phenylbenzo[4,5]furo[3,2 d]pyrimidin 4(3H) one
... allowed to stand for 10 h at 273–278 K, the solvent was removed under reduced pressure and diethyl ether/petroleum ether (1:2 v/v, 20 ml) was added to precipitate triphenylphosphine oxide. After filtration, the ...
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2 Ethoxy 3 isopropylbenzo[4,5]thieno[3,2 d]pyrimidin 4(3H) one
... To a solution of ethyl 3-triphenylphosphoranylideneaminobenzo[b]- thiophene-2-carboxylate (3 mmol) in dry dichloromethane (5 ml) was added isopropyl isocyanate (3 mmol) under nitrogen at room temperature. After ...
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3 Benzyl 2 butylamino 5,6,7,8 tetrahydrobenzothieno[2,3 d]pyrimidin 4(3H) one
... a crossed angle between the benzene ring and the above mentioned plane, and no disorder of the molecule. In the crystal structure, N—H O and weak C—H O hydrogen bonds link the molecules, forming one-dimensional ...
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2 Diethylamino 3 (3 methylphenyl) 1 benzofuro[3,2 d]pyrimidin 4(3H) one
... The centroid-to-centroid distances are 3.5173 (2) for rings A (O1, C1 C6, C7, C8) and B i (C1, C2, C3, C4, C5, C6) [symmetry code: (i) = 2 x, 2 y, 2 z] and 3.6726 (3) A ˚ for rings B and A ii ...
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Synthesis of 2 phenyl 3H dipyrimido[1,2 a] pyrimidin 4(5H) one derivatives and their antifungal activity
... The antifungal activity of the synthesized (4/3 substituted phenyl)-2-phenyl-3H-pyrido[1,2-a]pyrimido[5,4- e]pyrimidin-4(5H)-one derivatives (6a-j) (50µg/mL concentration) was compared ...
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Synthesis and antifungal activity of novel pyrimidin 2 one analogues
... internal standard. The chemical shifts are expressed in δ ppm. Mass spectra were obtained on Mass Lynx SCN781 spectrophotomer TOF mode. Elemental analysis was performed on a Thermo Finnigan Flash EA 1112 CHN analyzer. ...
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3 (4 Fluorophenyl) 2 (4 methylphenoxy) 5,8,9 trimethylthieno[3′,2′:5,6]pyrido[4,3 d]pyrimidin 4(3H) one
... In (I) (Fig. 1), the C—S bond lengths [1.730 (2) and 1.744 (2) A ˚ ] are greater than those observed in free thiophene [1.714 (s.u.) A ˚ ; Bonham & Momany, 1963] and thieno[2,3-c]- pyridine [1.728 (1) ...
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4 p Tolyl 1,3,4,4a,5,6,7,8a octahydro 2H pyrano[2,3 d]pyrimidin 2 one
... packing in the crystal structure of (I) (Fig. 2). In the hydrogen- bond system, the N atoms of the amine group act as hydrogen- bond donors and the O atom of the carbonyl group acts as a hydrogen-bond acceptor ...
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3 (4 Methoxyphenoxy) 2 phenyl 3H 1 benzofuro[3,2 d]pyrimidin 1 one
... To a solution of N-(2-ethoxycarbonylbenzofuran-3-yl)iminotri- phenylphosphorane (3 mmol) in dry methylene dichloride (15 ml) was added aromatic isocyanate (3 mmol) under nitrogen at room temperature. After the ...
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2 Ethoxy 3 phenyl 1 benzothieno[3,2 d]pyrimidin 4(3H) one
... seem to be effective in stabilizing the crystal structure (Fig. 2). The centroid–centroid distances between the S1/C6/C1/C7/C8 and C1–C6 rings, and between the N1/C7–C9/N2/C10 and C1– C6 rings are 3.777 (1) and ...
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3 (2 Aminophenyl) 2 methylsulfanyl 5,6,7,8 tetrahydrobenzothieno[2,3 d]pyrimidin 4(3H) one
... molecule forms weak hydrogen bonds with atoms N2 and O1 (Table 2 and Fig. 2). The former is an intramolecular hydrogen bond, which completes a closed five-membered loop. The latter is an intermolecular ...
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1 [(4 Methylbenzylidene)amino] 5 (4 methylbenzoyl) 4 (p tolyl)pyrimidin 2(1H) one
... 2000). 4-(4-Methylbenzoyl)-5-(4-methylphenyl)furan-2,3- dione, (1), and p-methylbenzaldehyde semicarbazone, (2), react with loss of carbon dioxide and water, yielding the 1- ...
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5 (4 Methylbenzoyl) 4 (4 methylphenyl) 1 [(1 phenylethylidene)amino]pyrimidin 2(1H) one
... 4-Aroyl-5-aryl-2,3-dihydrofuran-2,3-diones are obtained by reacting 1,3-dicarbonyl compounds with oxalyl halides. Dihydrofuran-2,3-dione chemistry has attracted much atten- tion for more than a few decades due to ...
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3 (4 Methylphenyl) 2 morpholinobenzo[4,5]furo[3,2 d]pyrimidin 4(3H) one
... Phenyl isocyanate (3 mmol) was added to a solution of imino- phosphorane (1.40 g, 3 mmol) in dry dichloromethane (15 ml) under nitrogen at room temperature. When the reaction mixture had stood for 10 h at 273–278 K, the ...
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