3-dioxygenase
Indoleamine 2,3 dioxygenase and tumor induced tolerance
... Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; ...
9
Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
... Abstract: Nanomedicine application in cancer immunotherapy is currently one of the most challenging areas in cancer therapeutic intervention. Innovative solutions have been provided by nanotechnology to deliver cytotoxic ...
14
B7 costimulation and intracellular indoleamine 2,3 dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non pregnant women
... Besides initiating signal transduction in T lymphocytes, B7-1 and B7-2 may back-signal into the APC and influ- ence the local immune environment through induced ex- pression of immunosuppressive factors independently of ...
9
The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection
... This review summarizes new insights that are emer- ging from recent studies, focusing on why Leishmania persistence is achieved, and the other on DC subsets. These may well be inter-connected. It is a well-known fact ...
8
H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma
... Indoleamine 2,3-dioxygenase 1 (IDO1), a ubiquitous mono- meric heme-containing enzyme, is the first rate-limiting en- zyme in the kynurenine pathway (KP) that catabolizes tryptophan (Trp) into kynurenine [1]. ...
15
Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells
... 2, 3-dioxygenase (IDO/INDO), an impor- tant enzyme in the metabolism of tryptophan, catalyzes the rate-limiting step of tryptophan degradation along the kynurenine ...
10
Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection
... Indoleamine 2,3-dioxygenase (IDO) mediates conversion of tryptophan to catabolites collectively known as kynurenines (22). This enzyme is expressed by both epithelial and dendritic cells induced by proinflammatory ...
5
Targeting the indoleamine 2,3-dioxygenase pathway in cancer
... that D-1MT acts as a potent tryptophan mimetic in mTOR regulation by restoration of mTOR pathway is one such possible mechanism of action [32]. Further, IDO-mediated catabolism of tryptophan also inhibits the ...
10
Original Article Expression and function analysis of indoleamine 2 and 3-dioxygenase in bladder urothelial carcinoma
... Abstract: Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for tryptophan metabolism inducing immune tolerance of tumors. The purpose of this study is to investigate IDO expression and its ...
8
Brain indoleamine 2,3 dioxygenase contributes to the comorbidity of pain and depression
... Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryp- ...
16
Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats
... Objectives: This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (ID[r] ...
12
Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1 in juvenile diabetes
... Although IDO1 is an enzyme recognized as an authentic immune regulator (11, 13, 15), other enzymes such as Trp 2,3-dioxygenase (TDO) and IDO2 catalyze the same reaction along the Kyn pathway (15, 34). In ...
18
Inhibition of experimental asthma by indoleamine 2,3 dioxygenase
... ing their contribution to the inhibition of lung inflammation via cognate interaction or via their secretion of IL-10 (35). The transfer models, therefore, establish the fundamental contribu- tion of activated innate ...
11
Original Article Overexpressed indoleamine 2, 3-dioxygenase induced T cell apoptosis via Fas/FasL and Bcl-2/Bax-related apoptotic pathways in metastatic breast cancer
... of the Bcl-2 gene family play a pivotal role in controlling the execution machinery of apopto- sis through the mitochondrial pathway. Kluck et al [24] revealed that Bcl-2 inhibited cyto- chrome c translocation, thereby ...
8
Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase
... including 3-hydroxykynurenine and 3-hydroxyanthranilic acid, which are free radical scavengers [11, 26, 70, 71]; (3) increasing cellular NAD levels, which indirectly helps to maintain cell viability ...
21
Regulation of indoleamine 2,3-dioxygenase in primary human saphenous vein endothelial cells
... Microporation apparatus, tips, buffers and the MP-1096 kit were purchased from Labtech International (Ringmer, UK). The desired number of cells were resuspended in 24 µ L of microporation suspension buffer and kept at 4 ...
10
Search | Preprints
... Ketoprofen as an Add-on Treatment to Sertraline for Drug-Naïve Major Depressed Patients:1. Normalization of Plasma Levels of Indoleamine-2,3-Dioxygenase in Association [r] ...
34
Thermophilic biodegradation of phenolic compounds
... Losses in cell viability can be encountered in polyacrylamide gel systems due to the toxic effect of its monomers acrylamide and bisacrylamide together with the heat of the polymerisation reaction (Woodward, 1985). ...
191
Enhanced therapeutic effect of an antiangiogenesis peptide on lung cancer in vivo combined with salmonella VNP20009 carrying a Sox2 shRNA construct
... Tumor growth is sustained by a small number of tumor-initiating cells known as cancer stem cells (CSCs). Sox2, a gene expressed at high level in stem cells, also plays a vital role in the regenesis of lung CSCs [10–12]. ...
11
Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders
... verted to N-formylkynurenine by either indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) and is the first rate limiting step. N-formylkynure- nine is then converted by a series of four ...
11