3 h
![6′ Bromo 1′H spiro[cyclohexane 1,2′ pyrido[2,3 d]pyrimidin] 4′(3′H) one](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
6′ Bromo 1′H spiro[cyclohexane 1,2′ pyrido[2,3 d]pyrimidin] 4′(3′H) one
... 2,3-Dihydropyrido[2,3-d]-pyrimidin-4(1H)-ones are a class of fused heterocycles which possess diuretic (Parish et al., 1982) and anti-bacterial activity (Narayana et al., 2009). 2-Substituted 2,3-dihydropyrido ...
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Spiro[cyclopropane 1,1′ 1H inden] 2′(3′H) one
... The title compound was conveniently prepared in two steps starting from indene (12.0 g, 0.103 mol). First, indene was allowed to react with 1,2-dibromoethane (13.4 ml, 0.155 mol) in the presence of ...
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Synthesis, Electrochemistry and Antitumor Activity of 1’H, 3’H(Me) spiro [(aza)benzimidazoline 2’, 3 (1,2 diferrocenylcyclopropenes)], 2 (1,2 Diferrocenylvinyl)benz and Azabenzimidazoles
... 6 h), forming the following products: bicyclic aza- and diazabenzimidazoles (cis-3d-f and trans-4d-f, ~3:1), as well as spirane azabenzimidazoles 5d,e and diazabenzimidazole 5f, ...O 3 , grade ...
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4′ (4 Chlorophenyl) 3′' ethyl 1′ methyl 1H indole 3 spiro 2′ pyrrolidine 3′ spiro 5′′ [1,3]thiazole 2(3H),2′′(3′′H),4′′(5′′H) trione benzene sesquisolvate
... Spiro-compounds represent an important class of naturally occurring substances, which in many cases exhibit interesting biological properties (Kobayashi et al., 1991; James et al., 1991). 1,3-Dipolar cycloaddition ...
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1 Benzyl 3 methyl 3′,5′ diphenylspiro[quinoxaline 2(1H),2′(3′H) 1,3,4 thiadiazole]
... N1 0.83510 (11) 0.22867 (9) 0.36228 (9) 0.0460 (3) N2 0.79303 (10) 0.23285 (9) 0.19279 (8) 0.0422 (2) N3 0.90581 (10) 0.34954 (9) 0.08824 (8) 0.0424 (2) N4 0.98330 (10) 0.33516 (8) −0.00567 (8) 0.0392 (2) N5 ...
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3 Acetyl 4 furyl 1 methylspiro[pyrrolidine 2,2′ indol] 2′(3′H) one
... A solution of furyl acetone (1 mmol), sarcosine (1 mmol) and isatin (1 mmol) was refluxed in aqueous methanol (20 ml) for 4 h. After completion of the reaction, as evidenced by thin-layer chromato- graphy, the ...
7
1 Benzoylacenaphthylene 1 spiro 3′ pyrrolizidine 2′ spiro 3′′ 1H indole 2,2′′(1H,3′′H) dione
... Keto atom O37 is displaced by 0.331 (1) AÊ from the ace- naphthylene plane, while keto atom O35 is displaced only 0.045 (2) AÊ from the oxindole plane; this is probably due to the different environment of the two O ...
10
7′ (4 Methoxyphenyl)chroman 3 spiro 6′ hexahydro 1H pyrrolo[1,2 c]thiazole 5′ spiro 3′′ 1′′H indole 4,2′′(3′′H) dione
... Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2001); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 ...
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Levels of (3)H-diethylstilbestrol in tissues of C(3)H mice resulting from continuous hormone administration.
... Diethylstilbestrol (DES), a synthetic estrogen, has the a b ility to induce mammary carcinoma in C^H mice. The results of many uptake studies of labelled estrogens have led to conflicting reports on the mechanism ...
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1′ Methyl 4′ phenyl H fluorene 9 spiro 3′ pyrrolidine 2′ spiro 3′′ 1H indol 2′'(3′′H) one
... A solution of 9-benzylidene ¯uorene (6 mmol), sarcosine (6 mmol) and isatin (6 mmol) was re¯uxed in aqueous methanol until the disappearance of the starting materials, as evidenced by TLC. On completion of the reaction, ...
10
Recent results from INDRA
... of 3 He and 3 H nuclei are presented in the up- per part of ...for 3 H isotopes have been corrected for particles punch- ing through the CsI detectors of INDRA at this ...
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4′ (4 Methylbenzoyl) 1′ methyldispiro[indole 3(2H),2′ pyrrolidine 3′,3′′(2′′H) indole] 2,2′′ dione
... A mixture of (E)-3-(4′-methylphenacylidine)oxindole (1 mmol), isatin (indole-2,3-dione) (1 mmol), and sarcosine (N- methylglycine) (1 mmol) was refluxed in aqueous methonal for 3 h. On completion of ...
11
Cyclohexanespiro 2′ [2′,3′,6′,7′ tetrahydro 1′H cyclopenta[d]pyrimidin] 4′(5′H) one
... Pyrimidin-4(5H)-ones are valuable synthetic intermediates, and represent a common structure found in various biologically active compounds Schramm et al., 1984). Functionalization of the pyrimidin-4(5H)-one group offers ...
7
Cloning, Expression, and Characterization of Ara h 3, a Major Peanut Allergen
... Ara h 3 (40 kDa) and contaminating proteins eluted when loaded in SJM-0 (Figure 7 (B) lane 3) and washed with SJM - 250 at a pH value of ...Ara h 3 (40 kDa). Even though, most of Ara ...
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CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease
... replicated in one study using demented AD patients [7] but not another using non-demented patients from earl- ier stages (Clinical Dementia Rating of 0.5) [8]. Discrep- ant findings have also been reported for CSF C3 and ...
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Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3)
... had no effect on Na/H antiporter activity. In the absence of hydrocortisone, acid incubation did not significantly increase activity, while in the presence of hydrocortisone, acid incubation caused a 36% increase ...
8
Effectiveness of a modified doctor–patient communication training Programme designed for surgical residents in China: a prospective, large-volume study at a single Centre
... Most scales used to evaluate DPC competency depend on external observers to judge whether participants were effective or ineffective at communication, as such a method is objective. However, patient satisfaction is also ...
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N—H+⋯Cl− and C—H⋯O interactions in 6 fluoro 3 (4 piperidinio)benz[d]isoxazole chloride
... Data collection: SMART (Bruker, 1998); cell re®nement: SAINT- Plus (Bruker, 2001); data reduction: SAINT-Plus; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to re®ne structure: SHELXL97 ...
8
Evaluation of the Hepa Wash®treatment in pigs with acute liver failure
... A laboratory prototype (Hepa Wash GmbH, München, Germany) was used to conduct the the Hepa Wash treatments. It is composed of three circuits: the blood, dialysate and Hepa Wash circuits (Figure 1). Approxi- mately 40 ...
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