4-PBA
Original Article Inhibition of ER stress by 4-PBA protects MCT-induced pulmonary arterial hypertension via reducing NLRP3 inflammasome activation
... (n=10), 4-PBA (Sigma Aldrich, USA) +MCT group ...the 4-PBA+MCT group, PAH rats received 4-PBA starting on the day of PAH induction and continuing for four ...The ...
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In vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response
... Moreover, 4-PBA administration significantly downregulated the expression of the cartilage markers in P0 BMSCs (P < ...+ 4-PBA groups at all indicated ...+ 4-PBA group ...
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GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells
... Methods: The effect of GSK-J4 on cell proliferation was assessed with CCK8, while cell cycle distribution and apop- tosis were analyzed using flow cytometry. The proteins related to cell cycle, cell apoptosis, ...
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<p>The Therapeutic Effect of Melatonin on GC by Inducing Cell Apoptosis and Autophagy Induced by Endoplasmic Reticulum Stress</p>
... inhibitor 4-PBA (1 mM) and autophagy inhibitor 3-MA were added to AGS cells after melatonin exposure for 24 ...h. 4-PBA is a chemical chaperone contributing to protein traf fi cking and folding ...
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The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII
... Interestingly, 4-PBA has been reported to increase the secretion of other coagulation factor vari- ants such as FVIII-F309S [27], FIX-R294Q [17], and pro- tein C-A267T ...that 4-PBA could ...
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<p>Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues induced by high-fat diet containing industrial trans-fatty acids</p>
... muscle and adipose cells. 54 It has been con fi rmed that the ability of glucose uptake is associated with the expression quantity of cellular GLUT4 in adipose. 55 Similar to pre- vious reports, we did not observe a ...
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Search | Preprints
... of PBA-GA, two independent animal experiments were ...of 4-PBA (30.0 mg/kg) in 1.0 mL of PBS; group 4 (PBA-GA-treated colitis group): oral gavage of PBA-GA ...of 4- ...
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Original Article Bortezomib induced autophagy to protect esophageal cancer cells from apoptosis through endoplasmic reticulum stress-mediated way
... Figure 4. BZ induces autophagy through ER stress-mediated way in EC cells. EC cells were treated with 4-PBA, BZ, BZ + 4-PBA, respectively, with non-treated cells as control. A, B. ...
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Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs- CHOP
... Figure 2: Piperlongumine selectively suppressed HCC cell migration or invasion in vitro. (A) Representative micrographs showed the effects of PL on L-02 cell migration after scratching. Confluent L-02 cells (normal ...
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Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro
... Moreover, 4-PBA is also a histone deacetylase inhibitor [24, 25] and chemical chaperone [26], leading respectively to research into its use as an anti-cancer agent and in protein misfolding diseases such as ...
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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
... Studies in CLAMS. Twenty-four–hour food intake was measured at the indicated times using the Oxymax feed scale device (Colum- bus Instruments). VO 2 rate and locomotor activity were continuously monitored using the ...
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Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM CSF paracrine
... We used the Ready-To-Glow ™ NF-κB Secreted Lucif- erase Reporter System (Clotech, Catalog No.631743), according to the manufacturer’s instructions. Mature 3T3-L1 cells were transiently transfected with pMetLuc2- control ...
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Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer
... Therapeutic approaches to overcome detrimental ER stress responses in tumor-associated myeloid cells Since the UPR appears to regulate anti-tumor immun- ity while promoting the intrinsic aggressiveness of ma- lignant ...
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Phenylbutyrate ameliorates high-fat diet-induced obesity via brown adipose tissue activation
... Figure 4. PBA increases genes related to BAT activation and glycolysis related enzyme, ...cells. PBA was administered for 30 min before ...with PBA for 12 h at a dose of 2 ...after PBA ...
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Exploring the Validity of the Short Version of the Problem Behaviours Assessment (PBA-s) for Huntington's disease: A Rasch Analysis.
... The PBA-s was developed by the EHDN Behavioural Working Group from an original 40-item version (PBA-HD), however, the shorter interview is more commonly used in clinical practice, as well as in multicentre ...
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BURIAL DATA TABLES
... Head Position Mutilation l~ Sex Pottery or Stuccoed Jade Shell Flint/ Other.. Pba.[r] ...
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Diagnosing pseudobulbar affect in traumatic brain injury
... The variety of terms and associated clinical descriptions has led to confusion in the literature regarding the scope and nature of the dysregulation of emotional expression. We have used the term “PBA” for this ...
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PRs-SMEs.pdf
... purpose. PBA shall lay down the minimum eligibility criteria with the prior approval of the State Bank of Pakistan for placement of evaluators on the panel to be maintained by ...
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STUDIES ON NITROGBN METABOLISM OF SALINITY STRESSED FIBLD PBA (PISUM SATIVUM, LINN.VAR. ARVENSIS)
... Table II: Effect of salinity levels on nitrogen fractions as the percentage of total nitrogen in root and shoots of field pea (mean of two times of application computed from[r] ...
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PBA Carotid endarterectomy (standard +- patch shunt) 301007
... Randomised trial comparing endovenous laser ablation of the great saphenous vein with high ligation and stripping in patients with varicose veins: short term results. Randomised clini[r] ...
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