5-HT1A receptor
Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor
... Since low and higher level of serum total cholesterol is a stable feature in some persons with recurrent major depression, the level of total cholesterol in blood sam- ples in patients with major depression has been ...
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Intra-Amygdala Injection of 5-HT1A Receptor Ligands Produces Differential Effects on the Behavior of High- and Low-Anxiety Wistar Rats
... of 5-HT1A receptors agonist and ...The 5-HT1A agonist 8-OH-DPAT decreased the duration of avoidance behavior in rats characterized by initially larger duration of avoidance behavior, but ...
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5 HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system
... higher 5- HT1a expression compared to the C allele in control hippocampal ...higher 5-HT1A receptor density compared to samples with a CC ...for 5 days or NGF and aphidicolin for ...
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Design and synthesis of 5-HT1A receptor ligands
... other 5-HT receptor subtypes.^® 5 -HT 3 receptors are present on neurons in many systems in the periphery and in the ...system, 5 -HT 3 receptors are thought to be involved in psychiatric ...
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Rivastigmine Restores 5 HT1A Receptor Levels in the Hippocampus of Olfactory Bulbectomized Mice
... Rivastigmine is a second-generation, carbamate-based reversible non-competitive inhibitor of both acetylcho- linesterase (AChE) and butyrylcholinesterase (BuChE) used to treat mild to moderate dementia in patients [20]. ...
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Short term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5 HT1A receptor expressed in HeLa cells
... (5-HT)1A receptor expressed in HeLa cells stimulates Na+/K+ ATPase activity as assessed by rubidium ...the receptor-associated signaling mechanisms was responsible for this ...effect. 5-HT ...
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The 5 HT1A receptor agonist buspirone improves esophageal motor function and symptoms in systemic sclerosis: a 4 week, open label trial
... Table 1 summarizes demographic characteristics, expres- sion and duration of disease, CT, baseline manometry, and severity of esophageal symptoms. The mean ampli- tude of distal esophageal contractions was 16.6 ± 9.6 ...
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2D QSAR of arylpiperazines as 5-HT1A receptor agonists
... were developed using aminotetralin derivatives without inclusion of the arylpiperazines containing the oxygen atom. A closer look at the structures of the present dataset shows that some of the arylpiperazines of the ...
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The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy
... ysis of variance (ANOVA) with region as a repeated measure to assess the effects of sex, MDD diagnosis, and the presence of mesial temporal sclerosis (MTS). We only included main effects in our model. Analyses were ...
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Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
... The 5-HT1A nGRE mediates synergistic repression by both high and low affinity glucocorticoid receptors (MR and GR), suggesting a key role in repres- sion of 5-HT1A receptors in the ...
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Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice
... the 5-HT1A G (-1019) allele and the role of Deaf1 in vivo , we have studied the Deaf1 knockout ...raphe 5-HT1A RNA and 5-HT1A autoreceptor-labeled cells were markedly increased, ...
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Cannabidiol enhancement of exposure therapy in treatment refractory patients with phobias: study protocol of a randomized controlled trial
... transient receptor potential vanilloid type 1 (TRVP1) and serotonin 1A (5-HT1A) receptor, and inhibits or in other ways negatively affects the function of the enzyme that degrades endogenously ...
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Dankoski_unc_0153D_14403.pdf
... a 5-HT1A receptor agonist revealed that firing rate was less sensitive, and release amplitude more sensitive, to this ...of 5-HT1A receptor sensitivity was not a total surprise: ...
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Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use
... synaptic 5-HT through serotonin transporter reuptake ...presynaptic 5-HT1A ...the 5-HT neuron interprets this initially as toxic ...the 5-HT neuron and excess 5-HT is next ...
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Ghrelin Regulates Energy Homeostasis Through Discrete Central and Peripheral Signaling Mechanisms
... the 5- HT1A ...of 5-HT1A receptor stimulation in different regions may cancel itself ...for 5-HT7 receptors as well (Eriksson TM, ...
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Original Article 5-Hydroxytryptamine inhibits neuronal high-voltage-activated calcium currents in the preoptic anterior hypothalamus via 5-hydroxytryptamine 1A and 7 receptors
... the 5-HT1A receptor was involved in heat loss [21, 23, ...the 5-HT1A receptor agonist 8-OH-DPAT could significantly decrease the HVA calcium current in PO/AH neurons, whereas the ...
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Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation
... of 5-hydroxytryptamine (5-HT)1A receptor involvement in mild serotonin ...coadministrating 5-HT1A agonistic psychotropics with selective serotonin reuptake inhibitors (SSRIs) has been ...
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NEW INSIGHTS INTO MOLECULAR TARGETS FOR DEPRESSION
... (CRF)-1 receptor antagonists, Inhibition of glucocorticoid function, substance P (Nk-1) antagonists, MCH1 receptor antagonists, Gal3 receptor antagonists, arginine vasopressin as the potential novel ...
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Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine
... Traditional non-opioid pharmacologic treatment to ameliorate symptoms of opioid withdrawal has mainly involved the off-label use of clonidine. This is be- cause there is a large release of norepinephrine during ...
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Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety related and substance abuse disorders
... Similarly, there is a single study of CBD and drug memory extinction. Injection of CBD (5 mg kg -1 ) prior to an extinction trial enhanced the subsequent reduction in cocaine and amphetamine place preference ...
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