6-gingerol
Molecular Docking and Dynamics (MD) Simulation of 6-gingerol and 6-shogaol Against Human Estrogen Receptor Alpha (ERɑ)
... exist. 6-gingerol is a major pungent phenolic compound found in ginger which has been reported to exhibit antioxidant activity through inhibition of phospholipid peroxidation supported by in vitro and in ...
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<p>Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin</p>
... intestinal symptoms caused by chemotherapy. 22 Pica is a kind of compulsive eating of non-nutritive substances, such as clay, and its pathophysiology is not clear yet. 23 In the current study, cisplatin treatment ...
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LOWERING THE BLOOD BRAIN BARRIER PERMEATION PROPERTY OF 6-GINGEROL THROUGH A STRUCTURAL MONOSUBSTITUTION MODIFICATION APPROACH FOR THE PREVENTION OF PSYCHOTROPIC SIDE EFFECTS: AN IN-SILICO PHARMACOKINETICS STUDY
... The P-glycoprotein (P-gp) is involved physiologically in the reduction of the harmful effects of toxic compounds, xenobiotics and drugs which the body is exposed to by constantly pumping them out of cells. The need for ...
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[6] Gingerol, from Zingiber officinale, potentiates GLP 1 mediated glucose stimulated insulin secretion pathway in pancreatic β cells and increases RAB8/RAB10 regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice
... Zingiber officinale Roscoe (Zingiberaceae), known as ginger, is one of the most widely consumed spices world- wide [1, 2]. Ginger has long been used in complemen- tary and alternative medicine preparations for the ...
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6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation
... from the diabetic group were incubated with different con- centrations of 6-gingerol (0.3–10 µ M) for 30 minutes before assessing the vasoconstriction and vasodilation responses, whereas the isolated aortae ...
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Stability-indicating RP-HPLC method for the determination of 6-gingerol in polyherbal formulations
... for 6-gingerol in the concentration range of ...determination 6-gingerol even in nanogram ...of 6-gingerol was also carried out under different stress conditions which showed ...
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6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression
... microenvironment. 6-gingerol (6G), the major bioactive component in ginger, stabilized this complex by enhancing the binding of VEGFa to VEGFR2 with non-pathway ...
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SIMULTANEOUS ESTIMATION OF GUGGULSTERONE E, GUGGULSTERONE Z, KBA, AKBA, WITHAFERIN A AND 6-GINGEROL BY USING HPLC-DAD METHOD FROM ARIFLEX TABLET FORMULATION
... Simple, accurate, precise, sensitive and validated HPLC method was developed for simultaneous determination of Guggulsterone E (GE), Guggulsterone Z (GZ), 11-keto-β-boswellic acid (KBA), 3- Acetyl 11-keto-β-boswellic ...
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Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells
... induced by the neat drug or the drug loaded nanoparti- cles on MCF-7 and HEpG2 cells for 24–72 h. The mor- phological and nuclear changes that take place, detected via a fluorescence staining protocol (i.e., use of ...
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[6] Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53 expressing Pancreatic Cancer Cells
... In this present study, we first investigated the effects of [6]-gingerol, a phenolic substance de- rived from ginger roots, on two pancreatic cancer cell lines. We found that [6]-gingerol ...
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Proteasome inhibition mediates p53 reactivation and anti- cancer activity of 6-Gingerol in cervical cancer cells
... (6)-Gingerol (1-[4’-hydroxy-3’-methoxyphenyl]- 5-hydroxy-3-decanone) (6G), one among the major pungent extracts of ginger (Zingiberofficinale Roscoe, Zingiberaceae), is a polyphenolicalkanone and has ...
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Influence of processing parameters on the yield and 6 gingerol content of Zingiber officinale extract
... [6] M Suekawa; A Ishige; K Yuasa; K Sudo; M Aburada; E Hosoya, J Pharmacobiodyn.1984, 7:836–848. [7] HY Young ; YL Luo; HY Cheng; WC Hsieh; JC Liao; WH Pen, J Ethnopharmacol. 2005, 96:207–210. [8] EC Kim; JK Min; ...
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Optimization protocol for the extraction of 6 gingerol and 6 shogaol from Zingiber officinale var rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology
... primarily 6-gingerol, 6-shogaol, zinger- one, phenolics, and flavonoids ...components, 6-gingerol was reported as the most abundant bioactive compound in ginger with various ...
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DEMONSTRATION OF LYMPHATIC UPTAKE OF (6)-GINGEROL SOLID LIPID NANOPARTICLES
... (6)-Gingerol, a disease modifying anti-rheumatoid drug (DMARD) agent in the treatment of Rheumatoid Arthritis is a potent inhibitor of COX-1, COX-2 activity, inhibits PGE2 production. It also inhibits the ...
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Temperature effects on diffusion coefficient for 6-gingerol and 6-shogaol in subcritical water extraction
... Abstract. 6-gingerol and 6-shogaol are the main constituents as anti-inflammatory or bioactive compounds from zingiber officinale ...for 6-gingerol and 6-shogaol were studied in ...
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ALLEVIATIVE EFFECT OF GINGEROL ON CELL MEDIATED AND HUMORAL IMMUNITY AND IMMUNE ORGANS AGAINST PENICILLIC ACID MYCOTOXICOSIS IN BROILER CHICKENS
... contains 6-gingerol (65-70%), 8-gingerol (22-25%) and 10-gingerol (7-10%) was obtained from ...acid. Gingerol was added at the levels of ...
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Red ginger (Zingiber officinale Roscoe var rubrum): a review
... A recent study conducted by Hapsari and Rahayuningsih (2014) showed the antihyperlipidemia effect of red ginger [25]. Thirty-four female subjects who suffered from hyperlipidemia were given red ginger drinks with a dose ...
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Changes in antioxidant and antibacterial activities as well as phytochemical constituents associated with ginger storage and polyphenol oxidase activity
... flavonoids, 6-gingerol and 6-shogaol) and changes in antioxidant and antibacterial activities of two of the Malaysian ginger varieties, Halia bentong and Halia ...
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Vol 6, No 6 (2020)
... Therefore, motor fitness, perception, cognition is important elements for the ability to batting, bowling, wicket keeping and fielding. On the other hand, successful ‘running between the wickets’ depends on efficient ...
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Unified Discrete Wavelet Transform with Ridge Regression and Principal Component Regression to Predict Concentration of Gingerol Compound in Ginger Crop
... Abstract Multivariate calibration model can be used as an alternative method to predict the concentration of a gingerol compound. The prediction usually are carried out chemically through a long and expensive ...
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