α catenin
β Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α catenin
... with α -catenin is important for efficient differentiation, which is in contrast to the findings of Kim et ...-catenin- α -catenin interaction may also be involved in the ...
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α Catenin dependent cytoskeletal tension controls Yap activity in the heart
... identified α T-catenin (Ctnna3) as a Yap target gene, but not α E-catenin (Ctnna1), suggesting a unique role for α T-catenin in CM cytoskeletal ...two α -catenin ...
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The Regulation of β-catenin signalling by α-catenin
... sporadic or hereditary colorectal tum ours, APC function is lost (Kinzler and Volgelstein, 1996). A nother effect of APC m utations m ight be altered cell m igration in the intestinal vilM, resulting from the inability ...
191
αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish
... How strongly cadherin-based junctions are involved in tissue shape generation is especially apparent during gastrulation, the developmental process in which germ layer progenitor cells migrate and rearrange their ...
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Lipopolysaccharide-induced α-catenin downregulation enhances the motility of human colorectal cancer cells in an NF-κB signaling-dependent manner
... USA). α -Catenin gene expression was quantified using SYBR Green PCR master mix (Applied Biosystems, Foster City, CA, USA) on the StepOnePlus system (Applied ...follows: α -catenin (F: 5 ′ ...
9
Polycystin 1, the PKD1 gene product, is in a complex containing E cadherin and the catenins
... What is the role of an interaction between polycystin-1 and the E-cadherin/catenin complex? One possibility is that polycystin-1 is involved in the formation of the E-cadherin/catenin complex. This ...
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Maternal β catenin and E cadherin in mouse development
... for α-catenin, GSK3Β, CSNK1A1, Reptin52 and RUVBL1 ...β- catenin, which in systems responsive to the WNT/β-catenin pathway causes detrimental ...
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Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway
... As shown in Figure 5, gain of PTEN function through exogenous expression of PTEN increased the expression of epithelial markers E-cadherin and α-catenin Figure 5E, reduced the expression[r] ...
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Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
... the catenin complex but is still able to mediate cell–cell adhesions, does not cause relocaliza- tion of YAP into the ...or α-catenin induces nuclear localization of YAP in dense cell cultures, as ...
14
Epithelial stem cell mutations that promote squamous cell carcinoma metastasis
... Next, we examined whether miR-9 overexpression directly pro- motes invasion using Matrigel-coated Transwell tissue culture plate assays. B911-miR-9, FaDu-miR-9, and Cal27-miR-9 cells showed significantly increased ...
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β Catenin is essential for Müllerian duct regression during male sexual differentiation
... - catenin mutant ...- catenin was inactivated by the Amhr2-Cre allele in males, sections with the cleaved caspase-3 positive Müllerian duct epithelium were significantly reduced ...
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Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method
... Recent advances have further illustrate how phosphoryla- tion and dephosphorylation of major components in the wnt pathway affect the stability of β-catenin and its TCF transcription activity [3-7]. It has been ...
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Galectin-3 and β-catenin are associated with a poor prognosis in serous epithelial ovarian cancer
... there were no significant differences of OS between patients with or without β -catenin nuclear staining. Also, they did not study the linkage between β -catenin expression and the clinicopathological ...
9
Original Article FAT1 inhibits the proliferation and metastasis of cervical cancer cells by binding β-catenin
... Abstract: FAT1 is a mutant gene found frequently in human cervical cancer (CC), but its expression and relevance in CC proliferation, invasion, and migration are still unknown. We aimed to explore the role and novel ...
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Regulation of bone mass by Wnt signaling
... Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth, differentiation, func- tion, and death. Considerable progress has been made in our understanding of the molecular links between ...
9
Activation of Wnt/β-catenin signalling promotes mesenchymal stem cells to repair injured alveolar epithelium induced by lipopolysaccharide in mice
... administered MSCs to migrate and home to inflamed, traumatised, ischaemic, and tumourous tissues [21-25] and their ability to specifically colonise the injured site, rather than intact loci [26]. Likewise, several ...
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Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta
... Osteogenesis imperfecta (OI) is a genetic disorder with se- vere bone abnormalities and is the most common form of primary osteoporosis in children [1]. Clinical phenotype may vary from prenatal lethal forms to milder ...
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Original Article Pegylated interferon-α inhibits the proliferation of hepatic oval cells through down-regulation of Wnt/β-catenin pathway
... We detected the inhibitory effects of PEG-IFN on the proliferation induced by Wnt3a using Brdu method. The Wnt3a-induced proliferation was largely affected by treatment of PEG-IFN even at low concentrations, and reached ...
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Exploring the Potential of -Catenin O-GlcNAcylation by Using Fluorescence-Based Engineering and Imaging
... In this study, we successfully adapted the dual labeling method initially developed by Lin and co-workers [12] to detect a -catenin glycoform using FRET techniques. As the selection of a suitable linker of ...
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Twist1 mediates repression of chondrogenesis by β catenin to promote cranial bone progenitor specification
... -catenin positively regulates Twist1 expression and negatively regulates chondrogenesis in cranial bone progenitors. We tested the Fig. 3. -catenin activates Twist1 expression. (A-L) Shown are coronal ...
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