α-SMA
Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion
... observed α-SMA-mediated con- tractility in response to ischemic injury and the role of calcium in the regulation of the contractile response, refine and expand our understanding of the pericytes in relation ...
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Inhibition of α-SMA by the Ectodomain of FGFR2c Attenuates Lung Fibrosis
... of α -smooth muscle actin ( α -SMA) in fibroblasts by transforming growth factor- β 1 (TGF- β 1) is an impor- tant step in the process of lung fibrosis, in which FGF-2, released by TGF-β1, is ...
11
Original Article Effect of early inhalation of budesonide on cyclinD1, VEGF and α-SMA in asthmatic rats
... at one week after asthma is induced in rats, and this increase was more significant at two weeks after induction. Under the action of mito- genetic substances, airway smooth muscle cells can not only proliferate, enlarge ...
10
Evaluation of Desmin, α-SMA and hTERT expression in pulmonary fibrosis and lung cancer
... of α-SMA in healthy controls and lung ibrosis may α-SMA marker be regarded as marker of ibrosis ...of α-SMA and TERT in healthy control and lung cancer, may implement these ...
9
Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts
... In the present study, we showed that TGF- β 1- mediated PI3 kinase/Akt activation may be important in the fibrogenic activation (ECM and α-SMA expression) of HIFs. However, the phosphorylated Akt alone does ...
12
Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study
... Glostrup, Denmark), Cy3 conjugated mouse anti α-SMA (clone 1A4; Sigma-Aldrich, St Louis, MO, USA). The ap- propriate secondary antibody for factor VIII was obtained from Invitrogen, Paisley, UK. As negative ...
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Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure
... many α-smooth muscle actin (α-SMA)- positive cancer associated fibroblasts (CAFs) which in turn lead to an increased of an aberrant extracellular matrix (ECM) production [6, ...
12
Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway
... I, α-smooth muscle actin (α-SMA), fibronectin, and con- nective tissue growth factor (CTGF), compared with eutopic endometrial MSCs from women with or without endometriosis and that endometriotic ...
13
New biomarkers for primary mitral regurgitation
... α -smooth muscle actin ( α -SMA) upon TGF- β 1 stimula- tion promoting alterations to the valve matrix architec- ture [5]. Other proteins like osteocalcin and low-density lipoprotein receptor-related ...
14
TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids
... α SMA: α -smooth muscle actin; BAL: bronchoalveolar lav- age; DAPI: 4',6-diamidino-2-phenylindole; EMT: epithe- lial to mesenchymal transition; HRPO: horseradish peroxidase; IPF: idiopa[r] ...
15
Clonorchis sinensis lysophospholipase A upregulates IL 25 expression in macrophages as a potential pathway to liver fibrosis
... against α-smooth muscle actin (α-SMA) (Proteintech, Chicago, USA), IL-25 (R&D, Minneap- olis, USA), total ERK1/2, phospho-ERK1/2, total AKT, phospho-AKT, phospho-B-Raf (Cell Signaling Technol- ...
10
Antischistosomal and anti inflammatory activity of garlic and allicin compared with that of praziquantel in vivo
... The standard avidin-biotin immunoperoxidase technique was used as described previously [26]. Paraffin samples (5 μm thick) were sectioned onto positively charged slides, deparaffinized in xylene, and hydrated in decreas- ...
11
Concomitant Retrograde Coronary Venous Infusion of Basic Fibroblast Growth Factor Enhances Engraftment and Differentiation of Bone Marrow Mesenchymal Stem Cells for Cardiac Repair after Myocardial Infarction
... LV remodeling is characterized by wall thinning and chamber dilatation and leads to worsen cardiac function. Previous studies have shown administration of stem cells can increase infarct wall thickness and improved ...
12
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
... contrast, α-smooth muscle actin (Acta2; also known as α-Sma) mRNA and that of other genes linked to airway remodeling, including collagen 1 and 3 (Col1a1 and Col3a1), fibronectin (Fn1), and ...
17
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
... anti-human α-SMA (dilution 1:1000; Cell Signaling, MA, USA), fibroblast specific protein-1 (FSP1 or S100A4, dilution 1:500; Santa Cruz Biotechnology, CA, USA), COL-1 (dilution 1:600; Enzo Life Science), and ...
11
FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis
... of α-smooth muscle actin (α-SMA) in phLF led to inhibition of migration without affecting the FAK signaling pathway ...reduces α-SMA expression in phLF ...
14
Gelatinases Increase in Bleomycin-induced Systemic Sclerosis Mouse Model
... of α –SMA, 5μm sections from injured skin and lung were deparaffinized and ...antibody α-SMA-HRP (1:500, Santa Cruz Biotechnology, USA) overnight at ...quantification, α- SMA ...
8
Biological Significance of Local TGF-β Activation in Liver Diseases
... TGF-β3-null mice die Abbreviations: α-SMA, α-smooth muscle actin; ADAMTS1, a disintegrin and metalloproteinase with thrombospondin motifs 1; CCl4 , carbon tetrachloride; DMN, dimethylnit[r] ...
11
Original Article Chemerin/chemR23 association with endothelial-mesenchymal transition in diabetic nephropathy
... and α-SMA ...and α-SMA protein expression experienced a upward trend (Figure 3C and ...and α-SMA is closely associated with the patho- genesis and progression of DN which is ...
9
The Alisma and Rhizoma decoction abates nonalcoholic steatohepatitis associated liver injuries in mice by modulating oxidative stress and autophagy
... Oxidative stress and its relevant pathway have a crucial role in liver injury and NAFLD [35]. Oxidative stress may initiate the cascade of HSC activation via the ac- tions of reactive oxidative species (ROS) and lipid ...
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