α-smooth muscle actin
FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis
... of α-smooth muscle actin (α-SMA) in phLF led to inhibition of migration without affecting the FAK signaling pathway ...in actin dynamics may underlie the observed inhibition of ...
14
Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
... as α–smooth muscle actin (αSMA), CollagenIα1, and tissue inhibitor of metalloproteinases–1 (TIMP-1), was significantly reduced when TGF-β–activated HSCs were exposed to iPSC-EVs for 24 hours ...
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Immunohistochemical Evaluation of Stromal Myofibroblasts by Alpha Smooth Muscle Actin in Potentially Malignant and Malignant Lesions of the Oral Cavity: A Retrospective study
... of α-smooth muscle actin myofibroblasts in oral VC cases as compared to complete positivity in OSCC which they attributed to the lack of inductive effect of genetically altered carcinomatous ...
109
IL-32γ attenuates airway fibrosis by modulating the integrin-FAK signaling pathway in fibroblasts
... and α -smooth muscle actin ( α -SMA) was examined and the transforming growth factor (TGF)- β -related signaling pathways was evaluated in activated human lung fibroblasts (MRC-5 cells) ...
10
S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair
... and α-smooth muscle actin (α-sma) mouse (Sigma-Aldrich, Italy), followed by the appropriate 488-Alexa fluorochrome- conjugated secondary antibodies (Invitrogen, ...
21
Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure
... many α-smooth muscle actin (α-SMA)- positive cancer associated fibroblasts (CAFs) which in turn lead to an increased of an aberrant extracellular matrix (ECM) production [6, ...
12
Acellular human lung scaffolds to model lung disease and tissue regeneration
... rATII: rat alveolar type II cells; IPF: idiopathic pulmonary fibrosis; HLF: human lung fibroblast; α -SMA: α -smooth muscle actin; iPSC: human induced pluripotent stem cell; ATII: alveol[r] ...
10
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
... contrast, α-smooth muscle actin (Acta2; also known as α-Sma) mRNA and that of other genes linked to airway remodeling, including collagen 1 and 3 (Col1a1 and Col3a1), fibronectin (Fn1), ...
17
Impaired Bronchoprotection Is Not Induced by Increased Smooth Muscle Mass in Chronic Treatment In Vivo with Formoterol in Asthmatic Mouse Model | WIMJ Open
... excess smooth muscle, including hyperplasia and hyper- trophy, is present in the airways of patients with ...together, smooth muscle amount, and changes in its mass are likely to be key ...
6
Original Article Ganoderma lucidum polysaccharides improve renal aging through upregulating SIRT1 expression
... of α-smooth muscle actin (α-SMA) and zinc finger E-box binding homeobox 1 (Zeb1), P16, P21, and sirtuin 1 (SIRT1) were explored in renal tissues of senescence-accelerated-resistant ...
8
Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway
... I, α-smooth muscle actin (α-SMA), fibronectin, and con- nective tissue growth factor (CTGF), compared with eutopic endometrial MSCs from women with or without endometriosis and that ...
13
Clonorchis sinensis lysophospholipase A upregulates IL 25 expression in macrophages as a potential pathway to liver fibrosis
... against α-smooth muscle actin (α-SMA) (Proteintech, Chicago, USA), IL-25 (R&D, Minneap- olis, USA), total ERK1/2, phospho-ERK1/2, total AKT, phospho-AKT, phospho-B-Raf (Cell ...
10
Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study
... angiopoietin; α -SMA: α smooth muscle actin; BV/mm 2 : number of vessels per square millimetre; CCP: cyclic citrullinated peptide; CRP: C-reactive protein; DAS: disease activity score; ...
10
Concomitant Retrograde Coronary Venous Infusion of Basic Fibroblast Growth Factor Enhances Engraftment and Differentiation of Bone Marrow Mesenchymal Stem Cells for Cardiac Repair after Myocardial Infarction
... Figure 5. Combined administration of basic fibroblast growth factor (bFGF) and mesenchymal stem cells (MSCs) induces neovascularization and inhibits apoptosis. Representative micrographs demonstrated formation of (A) new ...
12
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
... of α -smooth muscle actin ( α -SMA), fibroblast specific protein-1 (S100A4), COL-1, and FN were investigated by western blotting and quantitative real-time ...
11
Isolation and culture of smooth muscle cells from human acute type A aortic dissection
... them, α-smooth muscle actin is a relatively specific gene of which the expression is relatively restricted to vascular smooth muscle cells ...and actin-binding protein ...
6
Original Article All-trans retinoic acid in combination with collagen IV induces the differentiation of mouse embryonic stem cells into smooth muscle cells
... of smooth muscle cells (SMC) plays an important role in human diseases including atherosclerosis, hypertension and ...detect α-smooth muscle actin (α-SMA) and ...
7
Inhibition of airway remodeling in IL 5–deficient mice
... express α-smooth muscle actin and tenascin ...expressing α-smooth muscle actin ...influences smooth muscle layer thickness or levels of expression of ...
11
PAX7 is required for patterning the esophageal musculature
... anti-sarcomeric actin (5C5; 1:1000; Sigma-Aldrich), rabbit anti–α-smooth muscle actin (1:200; Abcam), rabbit anti-MyoD (1:500; Santa Cruz Biotechnology, ...
11
Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts
... monoclonal α-smooth muscle actin (α-SMA) antibody (A2547, Sigma-Aldrich), rabbit polyclonal fi- bronectin (FN) antibody (ab2413, Abcam, Cambridge, MA), rabbit polyclonal phospho-Akt ...
12