Acid-sensing ion channel
Original Article Roles of acid-sensing ion channel 3 and calcitonin gene-related peptide in the hypersensitivity of dorsal root ganglia neurons in a rat model of visceral pain
... neurotransmitters, ion channels, and receptors ...unclear. Acid-sensing ion ch- annels (ASICs) are a group of ion-permeable protein complexes commonly found on the cell ...sensitivity. ...
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Original Article Effect of activation of the Ca 2+ -permeable acid-sensing ion channel 1a on focal cerebral ischemia in diabetic rats
... The acid-sensing ion channel 1a (ASIC1a) plays an important role in brain ischemia [1, 2]. Application of ASIC1a blockers or genomic knockout of ASIC1a can reduce the volume of focal cerebral ...
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The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis
... Results: Acidic exposure led to up-regulation of the acid-sensing ion channel, ASIC2, in colorectal cancer (CRC) cells. ASIC2 overexpression in CRC cell lines, SW480 and HCT116, significantly ...
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Acid sensing ion channel 3 decreases phosphorylation of extracellular signal regulated kinases and induces synoviocyte cell death by increasing intracellular calcium
... Figure 2 Western blot analysis determines the responses of mitogen-activated protein kinases (MAPKs) after incubation in pH 6.0 or 7.4 in wild-type (WT), acid-sensing ion channel (ASIC3)-/- ...
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Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons
... which acid–base balance is disturbed because of over-accumulation of acid- ity in the body ...of acid-sensing ion channels (ASICs),the effects of acidosis on neuronal func- tion were ...
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Original Article Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc
... express acid-sensing ion channels (ASICs), gated by extracellular protons and mechanical forces, as well as neurotrophins and their signalling ...
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Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain
... Recent studies have shown that injections of inflamma- tory inducers result in Nav, TRPV1 and ASIC3 overex- pression in DRG neurons [2,30,31]. ASIC3 in primary afferent fibers respond to mechanical hyperalgesia of the ...
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Effect of Activation of the Ca2+ Permeable Acid Sensing Ion Channel 1a on Acid Induced Vascular Endothelial Cell Injury of Henoch Schönlein Purpura Children
... the development of osteoclasts in bone [15]. Our present study showed that extracellu- lar acid could significantly stimulate the expression of Calpains and Calcineurin in HDMECs pretreated with IgA1 from HSP ...
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Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons
... Acetic acid elicits an intense flinch/shaking response in rats ...acetic acid. In the present study, intraplantar injection of 20 μL acetic acid solution ...blocked acid-evoked pain (data not ...
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Amiloride blockable acid sensing ion channels are leading acid sensors expressed in human nociceptors
... and ion channels expressed in nociceptors ...and acid-sensing ion channel ASICs (2, ...VR1 channel requires extremely severe acidification to pH less than ...
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Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in
... ASIC: Acid-sensing ion channel; ASL: Arterial spin labelling; ATP: Adenosine triphosphate; BBB: Blood-brain barrier; BOLD: Blood oxygenation level dependent; BV: Brain volume; CBF: Cerebral ...
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Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an “acupuncture responding channel”
... the acid-sensing ion channel 3 (ASIC3) are mechanosensi- tive channels related to local ATP release in various tis- sues ...membrane channel proteins permeable to cations, as sodium and ...
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Acid sensing ion channels: potential therapeutic targets for neurologic diseases
... Amiloride, which is widely used clinically as a diuretic, inhibits Na + channels in renal tubular epithelial cells and is a non-specific inhibitor of ASICs [11]. With an IC50 of ~10-50 μM, amiloride not only suppresses ...
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Structure, function, and pharmacology of acid- sensing ion channels (ASICs): focus on ASIC1a
... this channel [68, 69], defining a ”gating ...the ion pore, the three residues (G-A-S) that probably form the ion-selective part of the molecular sieve [53, 55, 59] are magnified in the ...
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Functional modifications of acid-sensing ion channels by ligand-gated chloride channels
... gated ion channels, acid-sensing ion channels (ASICs) ...of channel gating [7]. Surprisingly, a chloride ion is partly embedded in the thumb domain, and each trimeric ...
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Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
... of acid-sensing and mechano-sensing in the same ...functional channel for the acid-induced current in all DRG proprioceptors, although these neu- rons are known as low-threshold ...both ...
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Diarylamidines: high potency inhibitors of acid- sensing ion channels
... nafamostat were downloaded from PDB bank. Rather than perform homology modeling of rat ASIC based on cASIC1 crystals in advance, we directly docked these chemicals into cASIC1 crystals (3HGC) to minimize possible ...
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Performance Analysis of Self-Scheduling Multi-channel Cognitive MAC Protocols under Imperfect Sensing Environment
... control channel and up to primary channels for data ...), Sensing-Sharing (SS) ( ), Contention ( ) and Transmission ( ) as shown in ...The Sensing-Sharing interval, during which SUs sense the primary ...
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Sparse massive MIMO OFDM channel estimation based on compressed sensing over frequency offset environment
... in channel impulse response (CIR) can be regarded as ...the channel delays of all transmit antenna can be consid- ered to be consistent due to the small transmission base station ...the channel ...
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Localizing the charged side chains of ion channels within the crowded charge models
... carboxylic acid side chain and one ammonium particle represents the side chain of the ...the ion species started the simulation with less than 2 ...each ion species was monitored and a warning given ...
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