activated protein kinase
Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
... inactive kinase to the nuclear compartment (Mizukami and Yoshida, ...was activated in response to reperfusion, suggesting an interface capable of ERK activation in the nuclear ...3- kinase) and the ...
12
Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
... AMP-activated protein kinase (AMPK) is a heterotrimeric Ser/Thr kinase consisting of catalytic (α) and regulatory (β and γ) subunits that acts as a key sensor of cellular and whole-body energy ...
17
Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)
... mitogen-activated protein kinase-activated protein kinase 5 ...MK5 protein is a highly conserved protein kinase within vertebrates sharing 87 to 99% amino ...
21
Mitogen-Activated Protein Kinase-Activated Kinase RSK2 Plays a Role in Innate Immune Responses to Influenza Virus Infection
... mitogen- activated protein kinase (MAPK) pathways, in mammalian cells (reviewed in references 10, 40, and ...serine/threonine kinase) activates MEK1/2 (a MAPK kinase kinase), ...
8
Modulation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 by Hepatitis C Virus Core Protein
... the protein array data, we per- formed an in vitro binding assay using His-tagged core protein purified from ...core protein interacted with endogenous MAPKAPK3 in ...bound protein was ...
14
PKM2, function and expression and regulation
... mitogen activated protein kinase; MAPKK5/MEK5: mitogen activated protein kinase kinase 5; MG: methylglyoxal; MLC2: myosin light chain 2; MiR/miRNA: microRNA; MUC-1: ...
25
Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3β-mediated c-FLIP<sub>L</sub> degradation in non-small cell lung cancer
... 35. Li M, Wang X, Meintzer MK, Laessig T, Birnbaum MJ, Heidenreich KA. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. Mol Cell Biol. 2000;20(24):9356–9363. 36. ...
9
Stem cells and the impact of ROS signaling
... modify protein function, the opposite is also true: a growing network of proteins have been shown to modulate ROS levels ...thioredoxin-interacting protein (TXNIP) may be implicated in hematopoietic stem ...
13
Flavonoids in modulation of cell survival signalling pathways
... N-terminal kinase (JNK), and p38, MAPKs (Johnson and Lapadat ...element-binding protein (CREB) (Arany et ...anti-apoptotic protein Bcl-2, and non- transcriptional inhibition of ...
9
A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases
... the kinase under investigation. The protein kinases of the mammalian genome can be divided into several groups ...mitogen-activated protein kinases (MAPKs) are strongly implicated in various ...
10
AMPK activation: a therapeutic target for type 2 diabetes?
... AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase whose activation elicits insulin-sensitizing effects, making it an ideal therapeutic target for ...is ...
13
Activation of mTOR: a culprit of Alzheimer’s disease?
... precursor protein (APP) metabolism and upregulating β- and ...(PI3-K)/protein kinase B (Akt), glycogen synthase kinase 3 [GSK-3], AMP-activated protein kinase (AMPK), and ...
16
Enhanced expression of microtubule-associated protein 7 functioned as a contributor to cervical cancer cell migration and is predictive of adverse prognosis
... Methods: The expression level of MAP7 in CC tissues and normal tissues were analyzed using the data obtained from The cancer genomes atlas (TCGA) and genotype‑tissue expression (GTEx) databases. The prognostic value of ...
16
Supplementing L-isoleucine increases medium protein and alters the expression of genes and proteins involved in milk protein synthesis and energy metabolism in bovine mammary cells
... milk protein synthesis, using an immortalized bovine mammary epithelial (MAC-T) cell ...for protein synthesis for each amino acid was determined by measuring the cell, medium and total protein at 0, ...
14
Molecular networks in skeletal muscle plasticity
... receptor protein II; Akt, protein kinase B; AMP, adenosine mono-phosphate; AMPK, AMP-activated protein kinase; BMP, bone morphogenic protein; DGK, diacylglycerol ...
9
PubMedCentral-PMC5198172.pdf
... a kinase network ...p21- activated kinases; PKD, protein kinase D; GRK, G-protein coupled receptor kinase; DMPK, dystrophia myotonica-protein kinase; CK, casein ...
15
Original Article Association detection between genetic variants in the microRNA binding sites of toll-like receptors signaling pathway genes and bladder cancer susceptibility
... TLRs signaling pathway genes polymorphisms and bladder cancer risk mitogen-activated protein kinase 1 protein kinase C, beta 1 protein kinase C, alpha protein kinase, cAMP-dependent, reg[r] ...
13
Kinase Activity Profiling of Gram-Negative Pneumonia
... approach. Kinase activity arrays enable the analysis of 1,024 con- sensus sequences of protein kinase ...a kinase activity array on whole lung lysates, cellular kinase activities were ...
7
From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis
... signal-regulating kinase 1; AP-1-Jun: Activator protein-1-JUN; ATP: Adenosine triphosphate; BCG: Bacillus Calmette-Guerin; Bcl-2: B-cell lymphoma 2; CARD15: Caspase associated recruitment domain 15; CD4+: ...
15
Molecular responses to abiotic stress and the development of drought tolerance in plants
... A gene encoding a mitogenactivated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, c[r] ...
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