active metabolite
Determination of venlafaxine and its active metabolite O-desmethylvenlafaxine in human plasma by HPLC fluorescence
... background Therapeutic drug monitoring guides clinical individualised medication by measuring plasma concentration, which could improve the curative effect, avoid drug overdose and reduce the incidence of adverse ...
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← Return to Article Details SOLID PHASE EXTRACTION AND LC-MS/MS METHOD FOR QUANTIFICATION OF VENLAFAXINE AND ITS ACTIVE METABOLITE O-DESMETHYL VENLAFAXINE IN RAT PLASMA
... its active metabolite O-desmethyl venlafaxine was develop and validated in rat ...its active metabolite with no interference at their retention time ...its active metabolite ODV ...
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EXAMINE THE SERUM ACTIVE METABOLITE FINDS NEW VARIANTS THAT EFFECTS CLOPIDOGREL PHARMACOKINETICS
... clopidogrel active metabolite formation, increased on-treatment platelet aggregation, and altered clinical events rates in patients with cardiovascular disease, prompting the FDA to update the clopidogrel ...
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Pharmacokinetic modelling of the anti malarial drug artesunate and its active metabolite dihydroartemisinin
... more active metabolite means that although ARS may make a significant contribution to parasite kill [17], it is often referred to as a pro-drug for DHA [3], and some researchers take the viewpoint that it is ...
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OPTIMIZATION STUDIES FOR CLOZAPINE BIOTRANSFORMATION TO ITS ACTIVE METABOLITE NORCLOZAPINE USING FUNGI
... its active metabolite norclozapine in human ...its active metabolite, norclozapine which was identified by HPLC, Mass spectroscopy and 1 HNMR ...on metabolite production was ...
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Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin.
... more active metabolite means that although ARS may make a significant contribution to parasite kill [17], it is often referred to as a pro-drug for DHA [3], and some researchers take the viewpoint that it is ...
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New liquid chromatographic method for simultaneous quantification of Atovaquone and Proguanil with its active metabolite Cycloguanil in human plasma
... The objective of present study was to develop a HPLC method for the simultaneous estimation of Atova- quone, Proguanil and its active metabolite Cycloguanil in human plasma. In the present study, method was ...
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Population pharmacokinetic modeling of flurbiprofen, the active metabolite of flurbiprofen axetil, in Chinese patients with postoperative pain
... To date, there is limited PPK information available on flurbiprofen axetil and its active metabolite flurbiprofen. In the present study, we used nonlinear mixed-effect modeling by Phoenix NLME to analyze ...
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The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
... LEF-M abrogates cytokine production in DCs. Dendritic cells (DCs) were differentiated and subsequently activated (100 ng/ml lipopolysac- charide [LPS]) in the presence or absence of the indicated concentra- tions of the ...
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A computational study of the chemical reactivity of isoxaflutole herbicide and its active metabolite using global and local descriptors
... its active metabolite in aqueous ...the active meta- bolite is more stable compared to ISOX, which compare favorably with the exp- erimental ...
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Simultaneous Spectrophotometric Determination of Mycophenolate Mofetil and Its Active Metabolite in Human Plasma Using Chemometrics Methods
... the active metabolite and it is conjugated to form a phenolic glucuronide conjugate [1], which is pharmacologically inactive but may be hydrolyzed in vivo to form free ...the active plasma ...
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Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
... its active metabolite (ACT-333679) to downregulate the profibrotic activity in primary cultures of SSc fibroblasts/myofibroblasts and the fibrogenic signaling molecules ...
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Molecular Characterization of a Fungus Producing Membrane Active Metabolite and Analysis of the Produced Secondary Metabolite
... applied using DAD detectors. We successfully combined PTLC and HPLC to isolate and characterize the biologically active secondary metabolites from the fungal sample, by recording chromatographic retention times ...
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Reprint of “Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin”
... In summary, there are currently no known coupled mecha- nistic pharmacokinetic models for artemisinin derivatives and corresponding metabolites in vivo , with observations made of the bl[r] ...
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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
... In order to understand the role of CYP 2D6 in the bio- transformation and bio-activation of primaquine, several experiments were conducted with primaquine and re- combinant CYP2D6. Primaquine was incubated with CYP2D6 ...
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Intracellular Disposition of Fludarabine Triphosphate in Human Natural Killer Cells
... its active metabolite that inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis in both actively dividing and resting cells ...
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Pharmacokinetics of Hydrochlorothiazide, Losartan and E3174 after Oral Doses of Losartan and Losartan/Hydrochlorothiazide in Healthy Chinese Male Volunteers
... an active and highly specific non-peptide angiotensin II receptor blocker, is applied for treating hypertension in clinic ...logically active metabolite E3174 (Figure ...
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Basal pharmacokinetic parameters of topically applied diacerein in pediatric patients with generalized severe epidermolysis bullosa simplex
... diacerein into its active metabolite during skin perme- ation. In addition, we were also interested in the amount of rhein present within the skin after 72 h. On average 368 μg (SD = 85.7 μg) rhein were ...
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1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line
... the active metabolite of vitamin D could increase the number of CaT1 calcium transporters in the plasma membrane and could there- fore be responsible for the higher rates of calcium influx seen across the ...
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Biologic effects of 1,25 dihydroxycholecalciferol (a highly active vitamin D metabolite) in acutely uremic rats
... The development of a vitamin D-resistant state in the course of renal failure may be responsible for reduced intestinal absorption of calcium and an impaired response of skeletal tissue. Moreover, the kidney has been ...
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