active site
The copper active site of CBM33 polysaccharide oxygenases
... unusual active site, where the copper ion is bound by two histidines of the so-called histidine brace (Figure ...The active site is notable for its τ -N-methylated N-terminal histidine, the ...
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The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions
... same site on the protein. Thus, a critical component of the active site of CtCE2, the catalytic Ser-His dyad, in harness with inserted aromatic residues, confers noncatalytic binding to cellulose ...
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Identification of Active-Site Amino Acid Residues in the Chiba Virus 3C-Like Protease
... Alanine-scanning mutagenesis - By analogy with chymotryp- sin and the picornavirus 3C proteases, it was likely that some of charged amino acid residues played critical roles in the prote- olysis in the NLV 3C-like ...
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Active site isolation in bismuth poisoned Pd/SiO2 catalysts for selective hydrogenation of furfural
... of active site ...Pd active site ensembles reducing adsorption of furfural via the aromatic ...lower site density decreases the probability of adsorption of furfural molecules nearby ...
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DRAFT. Active site backup. System Disaster Recovery Limitations and Best Practices
... the Active site or a Standby site temporarily experience an outage of a majority of their nodes, the Standby site can return to a synchronized state with the Active site only ...
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A single active site in the mariner transposase cleaves DNA strands of opposite polarity
... of active and catalytically inactive transposases, the six cleavage models predict different dis- tributions of ...the active and in- active monomers are recruited into the synaptic complex as ...
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Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.
... the active-site ...the active-site residues Cys-23 and His-120 on each domain oriented toward the interface which defines the active site for the ...
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A Ty1 Reverse Transcriptase Active-Site Aspartate Mutation Blocks Transposition but Not Polymerization
... third active-site carboxylate in polymerases comes from phylogenetic and site- directed mutagenesis studies of polymerases other than ...virus, site-directed mutation to either CGDN or CGDE ...
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Importance of Neuraminidase Active-Site Residues to the Neuraminidase Inhibitor Resistance of Influenza Viruses
... (iv) Structure analysis. The severe growth defect of E227D virus in vitro may explain why resistant variants with this mu- tation have not been isolated in nature. Examination of the NA structure (Fig. 1) shows that E227 ...
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Active site nature of magnesium dichloride-supported titanocene catalysts in olefin polymerization
... The active site nature of various MgCl 2 -supported metallocene catalysts was investigated in ethylene and propylene homopolymerization as well as in ethylene/1-hexene ...Ziegler-Natta-type active ...
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Three hydrolases and a transferase: comparative analysis of active site dynamics via the BioSimGrid database
... alternating active- sites mechanism of catalytic ...of active-site flexibility upon ligand binding, taking all samples (monomers and dimers) into account ...the active sites. Within the ...
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Variable Structural Networks at the Active Site of the SARS-CoV and SARS-CoV2 Main Proteases
... the active site by interacting with E166 (A) and F140 (A) and mediating inhibitor binding ...the active site, thus it is essential to consider a dimeric structure for ligand ...
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Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
... Schilling et al [24] have recently proposed that QC is a metalloenzyme based on time dependent inhibition by o- phenanthroline and dipicolinic acid, as well as the activa- tion of the inactive QC "apoenzyme" by ...
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Ultrafast infrared spectroscopy reveals water-mediated coherent dynamics in an enzyme active site
... of active site water to exchange also correlates with the need for efficient macroscopic transfer of water into or away from the active site while main- taining this structured dynamic nature ...
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The Surface Active Site Model for Formic Acid Electrooxidation at Palladium in Aqueous Acid Solution
... surface active site behaviour, Somorjai [7] highlighted the unique chemistry of surface irregularities (similar ideas have been expressed by Ertl [8]) and stressed that low coordination surface metal atoms ...
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Investigations into the Regulation of the Redox Activity of Protein Disulfide Isomerase by Active Site-Flanking Lysines
... Lysine residues play an important role to maintain protein structure and function, through hydrogen bonds or electrostatic interactions (Patel et al., 2011). The role of PDI active site-flanking lysines has ...
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The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity
... As we have demonstrated (Fig. 3 and Table1) mutations in the flexible loop structure markedly changed the catalytic power of POP resulting in orders of magnitude differences in activity. The pH-optimum of POP was also ...
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Computational Studies of Multi-Active Site Enzymes
... ligands more susceptible to hydrolysis than in bulk solution. Despite Thr-AMP and Ser- AMP differing by just an additional methylene (the extra -CH2- being in the side chain of the threonyl aminoacyl moiety), the ...
119
Folding, Stability and Active Site Conformation of Procaspase-3
... Under he lower pH. This interpretation is consistent with the results of the limited trypsin proteolysis, presented above, in which it was shown that at pH 7.2 R207 in loop L3 cleaved more slowly than R64, in loop L1, ...
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Evidence of Tryptophan at or near Active Site of Glucoamylase I of Arthrobotrys amerospora
... Protection by substrates or related compounds has been used to selectively prevent the modification of amino acid residues at active center of many enzymes. Glu I was reacted with starch at 0°C for 10 minutes then ...
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