Acute myeloid leukemia (AML)
Molecular targeting in acute myeloid leukemia
... Acute myeloid leukemia (AML) is a heterogenous disease associated with distinct genetic and molecular abnormali- ties. Somatic mutations result in dysregulation of intracellular signaling pathways, ...
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Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
... AML: Acute myeloid leukemia; BM: Bone marrow; CML: Chronic myeloid leukemia; CR: Complete remission; HSCT: Hematopoietic stem cell transplantation; PB: Peripheral blood; PBMCs: ...
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Emerging therapies for acute myeloid leukemia
... Acute myeloid leukemia (AML) is characterized by clinical and biological heterogeneity. Despite the advances in our understanding of its pathobiology, the chemotherapy-directed management has ...
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Original Article Prediction of gene signatures for diagnosing concurrent of acute myeloid leukemia and chronic lymphoblastic leukemia
... Abstract: Acute myeloid leukemia (AML) was found concurrent with a diagnosis of chronic lymphoblastic leukemia (CLL). The aim of this study is to predict pathologic or diagnostic markers ...
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FLT3 inhibitors in acute myeloid leukemia
... Acute myeloid leukemia (AML) remains a highly resist- ant disease to conventional chemotherapy, with a me- dian survival of only 4 months for relapsed and/or refractory disease ...
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Therapies for acute myeloid leukemia: vosaroxin
... Abstract: Vosaroxin, a quinolone-derivative chemotherapeutic agent, was considered a promising drug for the treatment of acute myeloid leukemia (AML). Early-stage clinical trials with this agent led ...
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A Morphological Study of Acute Myeloid Leukemia and Correlation With Clinical and Laboratory Findings, Including Results of Cytogenetic Analysis and Mutation Screening
... OF ACUTE MYELOID LEUKEMIA AND CORRELATION WITH CLINICAL AND LABORATORY FINDINGS, INCLUDING RESULTS OF CYTOGENETIC ANALYSIS AND MUTATION SCREENING” is a bona fide work done by ...
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Scopulariopsis Brevicaulis Infection in a Patient with Acute Myeloid Leukemia
... Scopulariopsis Brevicaulis Infection in a Patient with Acute Myeloid Leukemia CASE REPORT Scopu/ar;ops;s Brev;cau/;s Infection in a Patient with Acute Myeloid Leukemia 111111 , K P Ng, Ph D*, T S Soo[.] ...
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Precision therapy for acute myeloid leukemia
... promote leukemia regression in elderly patients unfit for induction chemotherapy [70, ...NPM1-mutated leukemia cells are associated with increased CD33 expression [72], CD33 antibodies like gemtuzumab ...
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Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT
... AL: Acute leukemia; ALL: Acute lymphoblastic leukemia; ALWP: Acute Leukemia Working Party; AML: Acute myeloid leukemia; ATG: Antithymocyte globulin; BM: Bone ...
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Rapid Efficacy of Gemtuzumab Ozogamicin in Refractory AML Patients with Organ Dysfunctions
... Keywords: acute myeloid leukemia; patients with organ dysfunction; gemtuzumab ozogamicin.. 26 27.[r] ...
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Prognostic factors and outcome of patients undergoing hematopoietic stem cell transplantation who are admitted to pediatric intensive care unit
... ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CML, chronic myelogenous leukemia; GVHD, graft-versus-host disease; HPS, Hemophagocytic syndrome; HSCT, ...
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MicroRNA-binding site polymorphisms in hematological malignancies
... Significance of a polymorphic nucleotide T deletion (rs34351976) in the 3’UTR of NPM1 was studied in acute myeloid leukemia (AML). NPM1 encodes for nucleophos- min, a molecular chaperone shuffling ...
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Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development
... various tissue samples are typically distributed in roughly the same way and their accumulation along the sequence outline the same functional regions. This general trend is demonstrated in Fig. 5a in the case of DNA ...
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Quality control, modeling, and visualization of CRISPR screens with MAGeCK VISPR
... two leukemia cell lines in the leukemia dataset (a), and two biological replicates of mouse ESC cells in the ESC dataset ...different leukemia subtypes (HL60: acute myeloid ...
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Cell Malignitation Associated To Chromosome Translocations. Clinical Manifestations in Two Pediatric Patients 46,Xy,T(1;4)(Q11q11) and 46,Xy,T(6;9)(P21;Q34)
... Although acute myeloid leukemia (AML), is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells ...
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Invasive fungal infection among hematopoietic stem cell transplantation patients with mechanical ventilation in the intensive care unit
... ALL: Acute Lymphoid Leukemia; AML: Acute Myeloid Leukemia; APACHE II: Acute Physiology and Chronic Health Evaluation II; BMT: Bone Marrow Transplantation; CML: Chronic ...
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<p>Tagraxofusp for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Brief Report on Emerging Data</p>
... of myeloid progenitors and play a key role in the regulation of hematopoiesis and in fl ammatory ...of myeloid progenitors, notably through the activation of the JAK/ STAT pathway after the reception of ...
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A unique set of complex chromosomal abnormalities in an infant with myeloid leukemia associated with Down syndrome
... the acute myeloid leukemia-Berlin-Frankfurt-Munich-2004 (AML-BFM 2004) treatment protocol for patients with Down syndrome; however, he experienced a poor clinical ...
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Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor
... with acute myeloid leukemia (AML) initially diagnosed as M5 and with karyotype ...common leukemia transcripts were evaluated by multiplex reverse transcriptase-polymerase chain reaction assay ...
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