Acyl-CoA Oxidase 1
Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl CoA oxidase 1 deficient fibroblasts
... by acyl- CoA oxidase 1 (ACOX1) deficiency with subse- quent impairment of peroxisomal fatty acid β- oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in ...
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Vol 70, No 4 (2018)
... NADPH oxidase, catalase (CAT), acyl-CoA oxidase 1 (ACOX1), mitogen-activated protein kinase (MAPK), mitogen-activated protein kinase HOG1 (HOG 1), and the G-protein α subunit ...
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Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
... and acyl-CoA oxidase 1 are induced at 3 months, possibly reflecting the need for efficient fatty acid β -oxidation, as a compensatory response to mitochondrial ...
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Chewing the fat: beta-oxidation in signalling and development
... by acyl CoA oxidase 1 (ACX1) 14,61 ...forms acyl-CoA and OPC:n-2 60,62 ...its CoA ester by a yet uncharacterised ...
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Effect of Cheonggukjang supplementation upon hepatic acyl-CoA synthase, carnitine palmitoyltransferase I, acyl-CoA oxidase and uncoupling protein 2 mRNA levels in C57BL/6J mice fed with high fat diet
... Soybean-based fermented foods such as Cheonggukjang are very popular in Korea. Cheonggukjang has traditionally been made with whole cooked soybean by fermenting with Bacillus subtilis for short-periods (2 days) without ...
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Zellweger spectrum disorders: clinical overview and management approach
... Especially Acyl-CoA oxidase type 1 (ACOX1) deficiency and D-bifunctional protein (DBP) deficiency show great overlap and in some cases, especially in the neonatal-infantile and childhood ...
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Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase
... over-accumulate acyl-CoAs We further asked if a block in the first step of the FA b -oxida- tion spiral resulted in over-accumulation of its precursors, ...free acyl-CoAs. Total acyl-CoAs were ...
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The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle
... Acadm: acyl-Coenzyme A dehydrogenase, medium chain; Acly: ATP citrate lyase; Acot7: acyl-CoA thioesterase 7; Acot9: acyl-CoA thioesterase 9; Acsl1: acyl-CoA synthetase ...
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Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?
... transporter 1; ACBP: Acyl binding protein; ACOX: acyl-CoA oxidase; ATCC: American Type Culture Collection; BSA: Fatty acid-free bovine serum albumin; CPT 1: Carnitine palmitoyl ...
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Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice
... 7.2, 1 mmol/L EDTA, 1 mmol/L dithio- threitol, 25 μmol/L ALLN (N-acetyl-leucyl-leucyl-norl-- leucina, a calpain and cathepsin inhibitor), 100 μmol/L leupeptin, 100 μmol/L AEBSF (4-(2-aminoethy1) ...
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Malonyl-CoA metabolism in skeletal muscle
... to 1 m unit per assay and accordingly lengthened the incubation time to 2 h, but still observed sufficient lack of linearity to preclude the use of internal ...acetyl- CoA per g ...
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Functions of rat acyl-CoA synthetases in bacteria and mammalian cells
... provides acyl-CoA substrates for TAG synthesis, which will be stored in lipid ...chain acyl-CoA synthetase 1; C, PKA catalytic subunit; Des, phosphodiesterase; FFA, free fatty acids; ...
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2 methylbutyryl CoA dehydrogenase deficiency associated with autism and mental retardation: a case report
... Growth and motor development were normal for his age. He crawled at the age of 9 months and walked unsup- ported at the age of 12 months. Speech development was significantly delayed. The family moved to Norway when he ...
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A crotonyl CoA reductase carboxylase independent pathway for assembly of unusual alkylmalonyl CoA polyketide synthase extender units
... propionyl- CoA carboxylase (PCC) assemble malonyl and methylmalonyl- CoA via carboxylation of acetyl- and propionyl-CoA, respectively 16,17 ...
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Recruitment of PI4KIIIβ to Coxsackievirus B3 Replication Organelles Is Independent of ACBD3, GBF1, and Arf1
... duction. GST-tagged proteins were purified with glutathione Sepharose 4B beads (GE Healthcare), and CVB3 3A(1-60)-His was purified using nickel-nitrilotriacetic acid (Ni-NTA) agarose beads (Qiagen). Strep- ACBD3 ...
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Emerging role of lipid metabolism alterations in Cancer stem cells
... Recent studies have further deepened our understanding of how lipid desaturation interplays with oncogenic signal- ing pathways to generate CSCs. It has been demonstrated that NF-kB signaling activation and ALDH1A1 ...
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Two bifunctional enzymes from the marine protist Thraustochytrium roseum: biochemical characterization of wax ester synthase/acyl-CoA:diacylglycerol acyltransferase activity catalyzing wax ester and triacylglycerol synthesis
... We further tested the ability of TrWSD4 and TrWSD5 to synthesize WEs or TAG by heterologous expression in the yeast (Saccharomyces cerevisiae) mutant H1246 which is deficient in storage lipid biosynthesis [31]. We cloned ...
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Grevengoed_unc_0153D_15339.pdf
... Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac ACSL activity, but its role in phospholipid synthesis has not been ...the acyl-chain composition of heart ...
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How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?
... The acyl-CoA substrate (red) is formed outside peroxisomes by the action of cytosolic or microsomal ...the acyl-CoA substrate partitions into the membrane where it interacts with the TMDs; the ...
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Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
... A proposed statin signalling pathway that stimulates EGP by activation of gluconeogenic genes was discovered in human liver cells [112]. Statin activates the pregnane X receptor (PXR) in the cytoplasm. PXR exerts a num- ...
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