acyl-CoA oxidase 3
Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
... and acyl-CoA oxidase 1 are induced at 3 months, possibly reflecting the need for efficient fatty acid β -oxidation, as a compensatory response to mitochondrial ...
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Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl CoA oxidase 1 deficient fibroblasts
... In a previous work, we have shown that P-NALD pa- tient-derived deficient fibroblasts exhibited a strongly re- duced number and enlarged size of peroxisomes [3]. Al- though no apparent genotype-phenotype ...
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Effect of Cheonggukjang supplementation upon hepatic acyl-CoA synthase, carnitine palmitoyltransferase I, acyl-CoA oxidase and uncoupling protein 2 mRNA levels in C57BL/6J mice fed with high fat diet
... 1). acyl-CoA oxidase catalyzes the first step of peroxisomal fatty acid b-oxidation, and its gene expression is regulated by the peroxisome proliferators- activated receptors (PPARs) ...hydratase/ ...
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Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase
... Quantitative RT-PCR analysis of the transcriptional expres- sion level of CrACX2 in the WT revealed that CrACX2 expression is upregulated two-fold during the N recovery phase (Figure 7a), in accordance with its role in ...
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Zellweger spectrum disorders: clinical overview and management approach
... Especially Acyl-CoA oxidase type 1 (ACOX1) deficiency and D-bifunctional protein (DBP) deficiency show great overlap and in some cases, especially in the neonatal-infantile and childhood period, can ...
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Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?
... ACBP: Acyl binding protein; ACOX: acyl-CoA oxidase; ATCC: American Type Culture Collection; BSA: Fatty acid-free bovine serum albumin; CPT 1: Carnitine palmitoyl transferase 1; DAG: ...
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Vol 70, No 4 (2018)
... NADPH oxidase, catalase (CAT), acyl-CoA oxidase 1 (ACOX1), mitogen-activated protein kinase (MAPK), mitogen-activated protein kinase HOG1 (HOG 1), and the G-protein α subunit play important ...
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Large deletion of the peroxisomal acyl CoA oxidase gene in pseudoneonatal adrenoleukodystrophy
... proteins. The gene spans approximately 30-40 kb and is poorly polymorphic. Southern blot analyses were performed in two previously reported siblings with an isolated peroxisomal acyl-CoA oxidase ...
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Non-esterified fatty acids in the ovary: friends or foes?
... ACO: Acyl CoA oxidase; ALA: α -linolenic acid; AMPK: 5 ′ adenosine monophosphate-activated protein kinase; ATF4: Activating transcription factor 4; cAMP: Cyclic adenosine monophosphate; CCND2: Cyclin ...
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Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice
... The frozen liver was homogenized in buffer A (3 mmol/ L Tris/HCl, pH 7.2, 1 mmol/L EDTA, 1 mmol/L dithio- threitol, 25 μmol/L ALLN (N-acetyl-leucyl-leucyl-norl-- leucina, a calpain and cathepsin inhibitor), 100 ...
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Localization of proteins in the cell wall of Mycobacterium avium subsp. paratuberculosis K10 by proteomic analysis
... pks13 gene encodes condensase, the enzyme that per- forms the final condensation step of mycolic acid bio- synthesis and is flanked by two genes, fadD32 and accD4, both of which have been indicated to play a role in the ...
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Characterization of long-chain acyl-CoA synthetases which stimulate secretion of fatty acids in green algae Chlamydomonas reinhardtii
... Intracellular lipid profiles of q-15, p-13 and cc849 were analyzed by GC-MASS. As shown in Fig. 6, almost all compositions increased with a significant statis- tical difference (P < 0.01) compared with wild type- ...
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Clinical and genetic characteristics of patients with fatty acid oxidation disorders identified by newborn screening
... inactivating or null alleles [25–28]. This correlation became more meaningful when the phenotype-genotype correlation was evaluated in all patients with VLCAD or LCHAD/MTP deficiencies, irrespective of the mode of ...
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Deciphering the gene expression profile of peroxisome proliferator activated receptor signaling pathway in the left atria of patients with mitral regurgitation
... (Fig. 3), glucose metabolism, energy utilization, and path- ologic remodeling (hypertrophy, myolysis, glycogen accu- mulation, apoptosis, autophagy and inflammation) in the atria of MR patients, either partly ...
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Mitochondrial trifunctional protein deficiency Catalytic heterogeneity of the mutant enzyme in two patients
... hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin fibroblasts from two patients with long-chain 3-hydroxyacyl-CoA dehydrogenase ...
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Recruitment of PI4KIIIβ to Coxsackievirus B3 Replication Organelles Is Independent of ACBD3, GBF1, and Arf1
... Members of the Enterovirus (poliovirus [PV], coxsackieviruses, and human rhinoviruses) and Kobuvirus (Aichi virus) genera in the Picornaviridae family rely on PI4KIII  (phosphatidylinositol-4-kinase III  ) for ...
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Two bifunctional enzymes from the marine protist Thraustochytrium roseum: biochemical characterization of wax ester synthase/acyl-CoA:diacylglycerol acyltransferase activity catalyzing wax ester and triacylglycerol synthesis
... thus, acyl-CoAs are still likely to be soluble physiological substrate for membrane-associated ...fatty acyl reductase which catalyzes the for- mation of fatty alcohol in WE ...
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A crotonyl CoA reductase carboxylase independent pathway for assembly of unusual alkylmalonyl CoA polyketide synthase extender units
... YCCs assemble other unusual PKS extender units. BLAST searches identified two other polyketide biosynthetic gene clusters that contain genes encoding an YCC b-subunit with the same specificity-conferring residues as S. ...
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Essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells
... negative effects on S6K1 and 4E-BP1 phosphorylation via the specific AA pathway that signals to mTOR complex 1 (mTORC1) [9]. Subsequent studies using bovine MEC have explored the effects of individual EAA on milk protein ...
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Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats
... long-chain acyl-CoA synthetase-1; ACSS1, Acyl-CoA Synthetase-1; ATGL, adipose triglyceride lipase; CD36, fatty acid transfer proteins; CEBP β , CCAAT-enhancer binding proteins; CON, control; ...
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